SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bo4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 1bo4 PROTEIN (SERRATIA
MARCESCENS
AMINOGLYCOSIDE-3-N-A
CETYLTRANSFERASE)
(Serratia
marcescens) 		5 / 11 ALA A 136
ILE A  77
LEU A 111
LEU A 129
ALA A  81
 None
None
COA  A 300 ( 3.9A)
None
None
 1.11A 1b02A-1bo4A:
0.0		 1b02A-1bo4A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_B_RITB301_1
(PROTEASE)		 1bo4 PROTEIN (SERRATIA
MARCESCENS
AMINOGLYCOSIDE-3-N-A
CETYLTRANSFERASE)
(Serratia
marcescens) 		4 / 7 GLY A  25
ILE A  26
ALA A 125
ILE A 122
 None
None
None
COA  A 300 ( 4.1A)
 0.73A 1n49A-1bo4A:
undetectable		 1n49A-1bo4A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 1bo4 PROTEIN (SERRATIA
MARCESCENS
AMINOGLYCOSIDE-3-N-A
CETYLTRANSFERASE)
(Serratia
marcescens) 		5 / 12 ALA A  92
GLN A 145
TYR A  57
ASP A  45
ASP A 110
 None
SPD  A 200 (-3.8A)
None
None
SPD  A 200 (-3.3A)
 1.30A 2nv4B-1bo4A:
0.0		 2nv4B-1bo4A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QL8_A_BEZA143_0
(PUTATIVE REDOX
PROTEIN)		 1bo4 PROTEIN (SERRATIA
MARCESCENS
AMINOGLYCOSIDE-3-N-A
CETYLTRANSFERASE)
(Serratia
marcescens) 		4 / 7 ALA A 125
THR A 124
ALA A 123
ARG A 119
 None
COA  A 300 ( 3.6A)
COA  A 300 ( 3.2A)
COA  A 300 ( 4.0A)
 0.99A 2ql8A-1bo4A:
undetectable
2ql8B-1bo4A:
2.2		 2ql8A-1bo4A:
25.15
2ql8B-1bo4A:
25.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GYQ_A_SAMA270_0
(RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE)		 1bo4 PROTEIN (SERRATIA
MARCESCENS
AMINOGLYCOSIDE-3-N-A
CETYLTRANSFERASE)
(Serratia
marcescens) 		5 / 12 LEU A 111
ALA A  92
GLY A  89
ILE A 108
LEU A 130
 COA  A 300 ( 3.9A)
None
None
None
None
 1.27A 3gyqA-1bo4A:
undetectable
3gyqB-1bo4A:
undetectable		 3gyqA-1bo4A:
24.71
3gyqB-1bo4A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_A_E20A604_1
(ACETYLCHOLINESTERASE)		 1bo4 PROTEIN (SERRATIA
MARCESCENS
AMINOGLYCOSIDE-3-N-A
CETYLTRANSFERASE)
(Serratia
marcescens) 		5 / 11 TYR A 109
TYR A  94
SER A  73
TYR A  66
GLY A  68
 SPD  A 200 (-3.8A)
None
None
None
None
 1.26A 4ey7A-1bo4A:
undetectable		 4ey7A-1bo4A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EY7_B_E20B605_1
(ACETYLCHOLINESTERASE)		 1bo4 PROTEIN (SERRATIA
MARCESCENS
AMINOGLYCOSIDE-3-N-A
CETYLTRANSFERASE)
(Serratia
marcescens) 		5 / 11 TYR A 109
TYR A  94
SER A  73
TYR A  66
GLY A  68
 SPD  A 200 (-3.8A)
None
None
None
None
 1.29A 4ey7B-1bo4A:
undetectable		 4ey7B-1bo4A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1X_A_017A101_2
(ASPARTYL PROTEASE)		 1bo4 PROTEIN (SERRATIA
MARCESCENS
AMINOGLYCOSIDE-3-N-A
CETYLTRANSFERASE)
(Serratia
marcescens) 		6 / 12 LEU A 160
ALA A 134
ILE A 106
ILE A  77
VAL A 144
ILE A 142
 None
 1.47A 4q1xB-1bo4A:
0.0		 4q1xB-1bo4A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 1bo4 PROTEIN (SERRATIA
MARCESCENS
AMINOGLYCOSIDE-3-N-A
CETYLTRANSFERASE)
(Serratia
marcescens) 		4 / 7 GLU A 105
TYR A 143
ALA A 134
GLY A 138
 None
 0.99A 5uxdA-1bo4A:
0.0		 5uxdA-1bo4A:
21.88