SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1boo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HMY_A_SAMA328_0
(HAEIII
METHYLTRANSFERASE)
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
4 / 8 PHE A 273
GLU A 294
ASP A  34
PRO A  55
SAH  A 401 (-4.6A)
SAH  A 401 (-2.9A)
SAH  A 401 (-4.0A)
SAH  A 401 (-3.9A)
0.74A 1hmyA-1booA:
5.7
1hmyA-1booA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
6 / 12 ASP A  34
PRO A  55
TRP A  75
PHE A 273
GLY A 275
SER A 276
SAH  A 401 (-4.0A)
SAH  A 401 (-3.9A)
None
SAH  A 401 (-4.6A)
SAH  A 401 (-3.5A)
SAH  A 401 (-2.7A)
0.71A 1nw5A-1booA:
24.0
1nw5A-1booA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB503_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
4 / 6 ALA A 252
ILE A 259
PRO A 255
GLU A 256
None
1.21A 1oniB-1booA:
0.0
1oniC-1booA:
0.0
1oniB-1booA:
19.14
1oniC-1booA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDS_A_SAMA5635_0
(PROTEIN RDMB)
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
5 / 12 GLY A 274
GLY A 275
GLU A 294
ASP A  34
SER A  53
None
SAH  A 401 (-3.5A)
SAH  A 401 (-2.9A)
SAH  A 401 (-4.0A)
SAH  A 401 (-3.4A)
1.08A 1xdsA-1booA:
5.6
1xdsA-1booA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
4 / 5 ASP A  74
LEU A  77
MET A 119
ARG A 118
None
1.37A 2gj5A-1booA:
undetectable
2gj5A-1booA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
4 / 6 THR A 278
MET A  51
PHE A 258
ILE A 259
SAH  A 401 (-4.0A)
None
None
None
1.35A 2w98B-1booA:
undetectable
2w98B-1booA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
7 / 12 SER A  53
PRO A  55
PHE A 250
PHE A 273
GLY A 275
THR A 278
GLU A 294
SAH  A 401 (-3.4A)
SAH  A 401 (-3.9A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.6A)
SAH  A 401 (-3.5A)
SAH  A 401 (-4.0A)
SAH  A 401 (-2.9A)
0.56A 2zifA-1booA:
21.9
2zifA-1booA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
6 / 12 SER A  53
PRO A  55
PHE A 250
PHE A 273
GLY A 275
TYR A 299
SAH  A 401 (-3.4A)
SAH  A 401 (-3.9A)
SAH  A 401 (-3.4A)
SAH  A 401 (-4.6A)
SAH  A 401 (-3.5A)
SAH  A 401 (-4.2A)
0.65A 2zifB-1booA:
22.2
2zifB-1booA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_1
(PUTATIVE
MODIFICATION
METHYLASE)
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
3 / 3 ASP A  34
THR A 278
GLU A 294
SAH  A 401 (-4.0A)
SAH  A 401 (-4.0A)
SAH  A 401 (-2.9A)
0.25A 2zifB-1booA:
22.2
2zifB-1booA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
5 / 12 LEU A 330
TYR A  23
GLU A 298
ALA A 301
ASP A 319
None
1.43A 3ou6D-1booA:
3.4
3ou6D-1booA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
5 / 5 HIS A 246
SER A 276
THR A 278
GLU A 294
ASP A  34
SAH  A 401 (-4.0A)
SAH  A 401 (-2.7A)
SAH  A 401 (-4.0A)
SAH  A 401 (-2.9A)
SAH  A 401 (-4.0A)
0.49A 3tm4A-1booA:
undetectable
3tm4A-1booA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
5 / 5 HIS A 246
SER A 276
THR A 278
GLU A 294
ASP A  34
SAH  A 401 (-4.0A)
SAH  A 401 (-2.7A)
SAH  A 401 (-4.0A)
SAH  A 401 (-2.9A)
SAH  A 401 (-4.0A)
0.48A 3tm4B-1booA:
2.3
3tm4B-1booA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
4 / 6 PRO A 140
GLY A  98
ALA A 248
GLN A  69
None
1.10A 4g0uA-1booA:
undetectable
4g0uA-1booA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HOJ_A_ACTA303_0
(REGF PROTEIN)
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
4 / 5 VAL A 115
ARG A 118
MET A 119
GLU A 122
None
0.56A 4hojA-1booA:
undetectable
4hojA-1booA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RJD_B_TFPB204_1
(CALMODULIN)
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
4 / 8 LEU A 281
GLY A 280
GLU A 284
ALA A  22
None
0.83A 4rjdA-1booA:
undetectable
4rjdB-1booA:
undetectable
4rjdA-1booA:
11.26
4rjdB-1booA:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
3 / 3 LEU A  49
ASP A  90
ILE A 272
None
0.70A 4xi3D-1booA:
0.0
4xi3D-1booA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
4 / 7 GLY A 275
SER A 276
ASP A  34
ASP A 271
SAH  A 401 (-3.5A)
SAH  A 401 (-2.7A)
SAH  A 401 (-4.0A)
SAH  A 401 ( 4.8A)
0.70A 5ergB-1booA:
3.9
5ergB-1booA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
4 / 7 GLY A 275
SER A 276
GLU A 294
ASP A  34
SAH  A 401 (-3.5A)
SAH  A 401 (-2.7A)
SAH  A 401 (-2.9A)
SAH  A 401 (-4.0A)
0.75A 5ergB-1booA:
3.9
5ergB-1booA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
6 / 12 ASP A  34
PRO A  55
PHE A 273
GLY A 274
THR A 278
GLU A 294
SAH  A 401 (-4.0A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.6A)
None
SAH  A 401 (-4.0A)
SAH  A 401 (-2.9A)
1.18A 5hfjA-1booA:
20.1
5hfjA-1booA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_A_SAMA301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
7 / 12 ASP A  34
PRO A  55
PHE A 273
GLY A 275
THR A 278
GLU A 294
TYR A 299
SAH  A 401 (-4.0A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.6A)
SAH  A 401 (-3.5A)
SAH  A 401 (-4.0A)
SAH  A 401 (-2.9A)
SAH  A 401 (-4.2A)
0.63A 5hfjA-1booA:
20.1
5hfjA-1booA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
6 / 12 HIS A 246
PHE A 273
GLY A 275
SER A 276
THR A 278
TYR A 299
SAH  A 401 (-4.0A)
SAH  A 401 (-4.6A)
SAH  A 401 (-3.5A)
SAH  A 401 (-2.7A)
SAH  A 401 (-4.0A)
SAH  A 401 (-4.2A)
0.73A 5hfjB-1booA:
19.9
5hfjB-1booA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_B_SAMB301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
6 / 12 PRO A  55
HIS A 246
PHE A 273
GLY A 275
THR A 278
TYR A 299
SAH  A 401 (-3.9A)
SAH  A 401 (-4.0A)
SAH  A 401 (-4.6A)
SAH  A 401 (-3.5A)
SAH  A 401 (-4.0A)
SAH  A 401 (-4.2A)
0.53A 5hfjB-1booA:
19.9
5hfjB-1booA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_C_SAMC301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
6 / 12 ASP A  34
PRO A  55
PHE A 273
GLY A 275
THR A 278
TYR A 299
SAH  A 401 (-4.0A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.6A)
SAH  A 401 (-3.5A)
SAH  A 401 (-4.0A)
SAH  A 401 (-4.2A)
0.58A 5hfjC-1booA:
20.4
5hfjC-1booA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_D_SAMD301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
8 / 12 ASP A  34
PRO A  55
PHE A 273
GLY A 275
SER A 276
THR A 278
GLU A 294
TYR A 299
SAH  A 401 (-4.0A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.6A)
SAH  A 401 (-3.5A)
SAH  A 401 (-2.7A)
SAH  A 401 (-4.0A)
SAH  A 401 (-2.9A)
SAH  A 401 (-4.2A)
0.60A 5hfjD-1booA:
19.2
5hfjD-1booA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_E_SAME301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
7 / 12 ASP A  34
PHE A 273
GLY A 275
SER A 276
THR A 278
GLU A 294
TYR A 299
SAH  A 401 (-4.0A)
SAH  A 401 (-4.6A)
SAH  A 401 (-3.5A)
SAH  A 401 (-2.7A)
SAH  A 401 (-4.0A)
SAH  A 401 (-2.9A)
SAH  A 401 (-4.2A)
0.45A 5hfjE-1booA:
20.0
5hfjE-1booA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
6 / 12 ASP A  34
PHE A 273
GLY A 275
SER A 276
GLU A 294
TYR A 299
SAH  A 401 (-4.0A)
SAH  A 401 (-4.6A)
SAH  A 401 (-3.5A)
SAH  A 401 (-2.7A)
SAH  A 401 (-2.9A)
SAH  A 401 (-4.2A)
0.80A 5hfjF-1booA:
19.8
5hfjF-1booA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_F_SAMF301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
6 / 12 ASP A  34
PRO A  55
PHE A 273
GLY A 275
GLU A 294
TYR A 299
SAH  A 401 (-4.0A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.6A)
SAH  A 401 (-3.5A)
SAH  A 401 (-2.9A)
SAH  A 401 (-4.2A)
0.62A 5hfjF-1booA:
19.8
5hfjF-1booA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
5 / 12 PRO A  55
PHE A 273
GLY A 275
THR A 278
TYR A 299
SAH  A 401 (-3.9A)
SAH  A 401 (-4.6A)
SAH  A 401 (-3.5A)
SAH  A 401 (-4.0A)
SAH  A 401 (-4.2A)
0.51A 5hfjG-1booA:
20.0
5hfjG-1booA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_1
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
4 / 4 ASP A  34
HIS A 246
SER A 276
GLU A 294
SAH  A 401 (-4.0A)
SAH  A 401 (-4.0A)
SAH  A 401 (-2.7A)
SAH  A 401 (-2.9A)
0.53A 5hfjG-1booA:
20.0
5hfjG-1booA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
6 / 12 ASP A  34
PRO A  55
PHE A 273
GLY A 275
THR A 278
TYR A 299
SAH  A 401 (-4.0A)
SAH  A 401 (-3.9A)
SAH  A 401 (-4.6A)
SAH  A 401 (-3.5A)
SAH  A 401 (-4.0A)
SAH  A 401 (-4.2A)
0.53A 5hfjH-1booA:
19.7
5hfjH-1booA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HJI_A_ADNA401_1
(TRNA
(GUANINE(37)-N1)-MET
HYLTRANSFERASE TRM5A)
1boo PROTEIN (N-4
CYTOSINE-SPECIFIC
METHYLTRANSFERASE
PVU II)

(Proteus
vulgaris)
5 / 11 PHE A 273
GLY A 275
GLU A 294
ASP A  34
PRO A  55
SAH  A 401 (-4.6A)
SAH  A 401 (-3.5A)
SAH  A 401 (-2.9A)
SAH  A 401 (-4.0A)
SAH  A 401 (-3.9A)
0.56A 5hjiA-1booA:
2.2
5hjiA-1booA:
22.98