SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bp1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		4 / 8 VAL A 433
TYR A 255
VAL A 254
LEU A 435
 None
None
PC1  A 777 (-4.8A)
None
 0.82A 1igxA-1bp1A:
0.0		 1igxA-1bp1A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1217_1
(LIPOPROTEIN LPPX)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		4 / 4 VAL A 254
LEU A 186
ILE A 130
LEU A  76
 PC1  A 777 (-4.8A)
PC1  A 777 (-4.7A)
None
None
 1.04A 2byoA-1bp1A:
2.3		 2byoA-1bp1A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		4 / 6 LEU A  29
LEU A  25
ILE A  32
ARG A  31
 None
PC1  A 777 ( 4.1A)
None
None
 0.99A 2rlfC-1bp1A:
0.0
2rlfD-1bp1A:
0.0		 2rlfC-1bp1A:
6.24
2rlfD-1bp1A:
6.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_B_VIBB223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		4 / 7 LEU A 440
LEU A 375
SER A 259
THR A 265
 None
PC1  A 778 (-4.3A)
None
None
 1.07A 3lm8B-1bp1A:
undetectable
3lm8D-1bp1A:
undetectable		 3lm8B-1bp1A:
17.11
3lm8D-1bp1A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_2
(ADENOSINE KINASE,
PUTATIVE)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		4 / 5 LEU A 154
GLY A 152
MET A 100
PHE A  41
 None
 1.12A 3uq6B-1bp1A:
undetectable		 3uq6B-1bp1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		4 / 4 LEU A 154
GLY A 152
MET A 100
PHE A  41
 None
 1.11A 3vaqB-1bp1A:
undetectable		 3vaqB-1bp1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		5 / 10 LYS A 420
PRO A 426
ILE A 205
ILE A 199
ASP A 200
 PC1  A 778 (-4.5A)
None
None
None
PC1  A 778 ( 4.6A)
 1.31A 4dtaA-1bp1A:
undetectable		 4dtaA-1bp1A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		4 / 6 PHE A 335
ASN A 264
ALA A 266
LEU A 276
 PC1  A 778 (-4.7A)
None
PC1  A 778 (-3.3A)
PC1  A 778 (-3.9A)
 1.01A 4ejgD-1bp1A:
undetectable		 4ejgD-1bp1A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JX1_E_CAME502_0
(CAMPHOR
5-MONOOXYGENASE)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		4 / 5 PHE A 396
THR A 295
PHE A 301
ILE A 393
 None
 1.23A 4jx1E-1bp1A:
0.0		 4jx1E-1bp1A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		4 / 5 PHE A 425
PHE A 262
LEU A 333
PRO A 442
 PC1  A 778 (-4.7A)
None
None
None
 1.41A 4o8zA-1bp1A:
undetectable		 4o8zA-1bp1A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		4 / 5 LEU A 157
PHE A  53
ILE A 155
ILE A 146
 None
 1.06A 5dzk4-1bp1A:
undetectable
5dzkg-1bp1A:
undetectable
5dzkm-1bp1A:
undetectable
5dzkn-1bp1A:
undetectable		 5dzk4-1bp1A:
0.52
5dzkg-1bp1A:
19.73
5dzkm-1bp1A:
18.96
5dzkn-1bp1A:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		4 / 8 ILE A   9
ALA A 451
VAL A 453
VAL A   7
 PC1  A 777 (-3.9A)
None
None
PC1  A 777 (-4.6A)
 0.89A 5ecnD-1bp1A:
1.9		 5ecnD-1bp1A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_A_SAMA301_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A   4
GLY A 226
GLY A 208
GLU A 227
ASP A 260
 None
 0.81A 5ehgA-1bp1A:
undetectable		 5ehgA-1bp1A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC0_A_RBFA303_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		3 / 3 LYS A  77
LEU A 220
ILE A 130
 None
PC1  A 777 ( 4.7A)
None
 0.72A 5kc0A-1bp1A:
undetectable		 5kc0A-1bp1A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQR_A_SAMA301_0
(METHYLTRANSFERASE)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		5 / 12 GLY A   4
GLY A 226
GLY A 208
GLU A 227
ASP A 260
 None
 0.95A 5kqrA-1bp1A:
undetectable		 5kqrA-1bp1A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XV7_A_EMHA705_1
(SERINE-ARGININE (SR)
PROTEIN KINASE 1)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		5 / 12 LEU A 256
GLY A 257
GLY A 450
LEU A 427
ALA A 249
 None
 0.87A 5xv7A-1bp1A:
undetectable		 5xv7A-1bp1A:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9M_A_NIOA401_1
(CASEIN KINASE II
SUBUNIT ALPHA')		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		4 / 8 LEU A 106
VAL A 144
VAL A 142
ILE A 162
 None
 0.65A 5y9mA-1bp1A:
undetectable		 5y9mA-1bp1A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		4 / 4 PRO A 430
MET A 224
GLY A   4
VAL A   7
 PC1  A 777 (-4.7A)
None
None
PC1  A 777 (-4.6A)
 1.39A 6ak3A-1bp1A:
0.0		 6ak3A-1bp1A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AK3_A_P2EA1201_1
(PROSTAGLANDIN E2
RECEPTOR EP3
SUBTYPE,SOLUBLE
CYTOCHROME B562)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		4 / 4 PRO A 430
MET A 224
GLY A 226
VAL A   7
 PC1  A 777 (-4.7A)
None
None
PC1  A 777 (-4.6A)
 1.48A 6ak3A-1bp1A:
0.0		 6ak3A-1bp1A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_A_TKTA508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		4 / 8 ASP A  57
ILE A  58
ARG A  59
ASN A  84
 None
 1.21A 6hisA-1bp1A:
0.0
6hisB-1bp1A:
0.0		 6hisA-1bp1A:
14.68
6hisB-1bp1A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_B_TKTB508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		4 / 8 ASP A  57
ILE A  58
ARG A  59
ASN A  84
 None
 1.22A 6hisB-1bp1A:
0.0
6hisC-1bp1A:
0.0		 6hisB-1bp1A:
14.68
6hisC-1bp1A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_C_TKTC508_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		4 / 8 ASP A  57
ILE A  58
ARG A  59
ASN A  84
 None
 1.21A 6hisC-1bp1A:
0.0
6hisD-1bp1A:
0.0		 6hisC-1bp1A:
14.68
6hisD-1bp1A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_D_TKTD501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		4 / 8 ASP A  57
ILE A  58
ARG A  59
ASN A  84
 None
 1.22A 6hisD-1bp1A:
0.0
6hisE-1bp1A:
0.0		 6hisD-1bp1A:
14.68
6hisE-1bp1A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HIS_E_TKTE501_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 3A)		 1bp1 BACTERICIDAL/PERMEAB
ILITY-INCREASING
PROTEIN
(Homo
sapiens) 		4 / 8 ASN A  84
ASP A  57
ILE A  58
ARG A  59
 None
 1.22A 6hisA-1bp1A:
0.0
6hisE-1bp1A:
0.0		 6hisA-1bp1A:
14.68
6hisE-1bp1A:
14.68