SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bqc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		4 / 6 TYR A 198
GLY A 227
GLY A 224
SER A 255
 None
 0.99A 1eswA-1bqcA:
7.1		 1eswA-1bqcA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HPV_B_478B200_1
(HIV-1 PROTEASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 9 GLY A 227
ILE A 195
GLY A 224
ILE A 252
ILE A 240
 None
 0.93A 1hpvA-1bqcA:
0.0		 1hpvA-1bqcA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_2
(PROTEASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 12 GLY A 227
ILE A 195
GLY A 224
ILE A 252
ILE A 240
 None
 0.83A 1muiB-1bqcA:
0.0		 1muiB-1bqcA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N49_D_RITD401_1
(PROTEASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 11 GLY A 227
ILE A 195
GLY A 224
ILE A 252
ILE A 240
 None
 0.94A 1n49C-1bqcA:
undetectable		 1n49C-1bqcA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		3 / 3 ASP A  87
THR A  89
GLU A 225
 None
 0.86A 1pj7A-1bqcA:
undetectable		 1pj7A-1bqcA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_2
(PROTEASE RETROPEPSIN)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 12 GLY A 227
ILE A 195
GLY A 224
ILE A 252
ILE A 240
 None
 0.89A 1sduB-1bqcA:
undetectable		 1sduB-1bqcA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AB2_B_SNLB503_1
(MINERALOCORTICOID
RECEPTOR)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 12 LEU A  79
ASN A  47
ALA A 295
MET A 268
PHE A  19
 None
 1.48A 2ab2B-1bqcA:
undetectable		 2ab2B-1bqcA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_2
(HIV-1 PROTEASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 11 GLY A 227
ILE A 195
GLY A 224
ILE A 252
ILE A 240
 None
 0.87A 2aquB-1bqcA:
undetectable		 2aquB-1bqcA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FXE_A_DR7A102_2
(POL PROTEIN)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 11 GLY A 227
ILE A 195
GLY A 224
ILE A 252
ILE A 240
 None
 0.88A 2fxeB-1bqcA:
undetectable		 2fxeB-1bqcA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4S_A_AB1A400_2
(PROTEASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 12 GLY A 227
ILE A 195
GLY A 224
ILE A 252
ILE A 240
 None
 0.92A 2o4sB-1bqcA:
undetectable		 2o4sB-1bqcA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QO6_A_CHDA130_0
(LIVER-BASIC FATTY
ACID BINDING PROTEIN)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 12 LEU A  83
LEU A  53
VAL A 113
ASP A  66
PHE A  38
 None
 1.20A 2qo6A-1bqcA:
0.0		 2qo6A-1bqcA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_2
(PROTEASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 11 GLY A 227
ILE A 195
GLY A 224
ILE A 252
ILE A 240
 None
 0.89A 2r5qB-1bqcA:
undetectable		 2r5qB-1bqcA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_2
(PROTEASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 10 GLY A 227
ILE A 195
GLY A 224
ILE A 252
ILE A 240
 None
 0.89A 2r5qD-1bqcA:
0.0		 2r5qD-1bqcA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_A_NBVA1503_1
(GLUCOSYLCERAMIDASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		6 / 12 ASN A 127
GLU A 128
HIS A 196
TYR A 198
GLU A 225
TRP A 254
 None
 0.67A 2v3dA-1bqcA:
7.1		 2v3dA-1bqcA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 11 ASN A 127
GLU A 128
TYR A 198
GLU A 225
TRP A 254
 None
 0.75A 2v3dB-1bqcA:
4.1		 2v3dB-1bqcA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7W_C_SALC1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		4 / 7 THR A 294
ILE A 291
GLY A 290
PHE A 226
 None
 0.88A 2y7wC-1bqcA:
0.0		 2y7wC-1bqcA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_D_SAMD301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 12 GLY A 126
THR A  88
SER A 194
ILE A 123
ASP A  87
 None
 1.20A 3iv6D-1bqcA:
undetectable		 3iv6D-1bqcA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 11 GLY A 126
GLU A  84
LEU A  53
ASN A  62
LEU A  83
 None
 1.32A 3ndvA-1bqcA:
0.0
3ndvB-1bqcA:
0.0		 3ndvA-1bqcA:
21.76
3ndvB-1bqcA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 11 LEU A  83
GLY A 126
GLU A  84
LEU A  53
ASN A  62
 None
 1.29A 3ndvA-1bqcA:
0.0
3ndvB-1bqcA:
0.0		 3ndvA-1bqcA:
21.76
3ndvB-1bqcA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 11 GLY A 126
GLU A  84
LEU A  53
ASN A  62
LEU A  83
 None
 1.31A 3ndvC-1bqcA:
0.0
3ndvD-1bqcA:
0.0		 3ndvC-1bqcA:
21.76
3ndvD-1bqcA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 11 LEU A  83
GLY A 126
GLU A  84
LEU A  53
ASN A  62
 None
 1.32A 3ndvC-1bqcA:
0.0
3ndvD-1bqcA:
0.0		 3ndvC-1bqcA:
21.76
3ndvD-1bqcA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDX_A_RITA100_2
(PROTEASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 11 GLY A 227
ILE A 195
GLY A 224
ILE A 252
ILE A 240
 None
 0.85A 3ndxB-1bqcA:
undetectable		 3ndxB-1bqcA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_H_LFXH101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		4 / 5 SER A 278
GLY A 253
GLU A 128
GLU A 225
 None
 1.49A 3raeB-1bqcA:
0.0
3raeD-1bqcA:
0.4		 3raeB-1bqcA:
22.22
3raeD-1bqcA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 12 PHE A 301
GLY A   3
LEU A   4
GLU A  13
PHE A  19
 None
 1.21A 3tbgA-1bqcA:
0.0		 3tbgA-1bqcA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_C_RTZC1_1
(CYTOCHROME P450 2D6)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 12 PHE A 301
GLY A   3
LEU A   4
GLU A  13
PHE A  19
 None
 1.36A 3tbgC-1bqcA:
undetectable		 3tbgC-1bqcA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_3
(PROTEASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 12 GLY A 227
ILE A 195
GLY A 224
ILE A 252
ILE A 240
 None
 0.84A 3tl9B-1bqcA:
undetectable		 3tl9B-1bqcA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		4 / 7 ALA A 295
GLY A 250
ILE A 252
GLY A  23
 None
 0.57A 4eatA-1bqcA:
undetectable		 4eatA-1bqcA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MF6_A_BEZA303_0
(GLUTATHIONE
S-TRANSFERASE DOMAIN)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		4 / 5 THR A 174
PHE A 214
ASN A 173
TYR A 210
 None
 1.49A 4mf6A-1bqcA:
0.0		 4mf6A-1bqcA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 11 GLY A 227
ILE A 195
GLY A 224
ILE A 252
ILE A 240
 None
 0.84A 4njvC-1bqcA:
0.0		 4njvC-1bqcA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		4 / 8 THR A  48
GLU A  84
ASN A 124
GLY A  23
 None
 0.85A 4r3aA-1bqcA:
undetectable		 4r3aA-1bqcA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		4 / 7 PHE A 214
ASP A 170
ILE A 195
TYR A 201
 None
 1.32A 5a06B-1bqcA:
1.2		 5a06B-1bqcA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_G_SAMG301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		5 / 12 ALA A 138
PRO A 165
GLN A  94
GLY A  92
SER A 134
 None
 1.27A 5hfjG-1bqcA:
2.1		 5hfjG-1bqcA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		4 / 8 TYR A 210
ASP A 170
THR A 174
VAL A 182
 None
 1.28A 5ov9B-1bqcA:
2.5		 5ov9B-1bqcA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1bqc PROTEIN
(BETA-MANNANASE)
(Thermobifida
fusca) 		4 / 5 LEU A 122
TYR A 120
LEU A   4
GLU A  13
 None
 1.32A 5weaA-1bqcA:
undetectable		 5weaA-1bqcA:
16.26