SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1brl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I1E_A_DM2A3001_1
(BOTULINUM NEUROTOXIN
TYPE B)		 1brl BACTERIAL LUCIFERASE
(Vibrio
harveyi) 		5 / 9 GLU A 181
GLU A 185
GLY A 187
HIS A 215
TYR A 208
 None
 1.38A 1i1eA-1brlA:
0.0		 1i1eA-1brlA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_B_BEZB12_0
(CES1 PROTEIN)		 1brl BACTERIAL LUCIFERASE
(Vibrio
harveyi) 		4 / 4 GLY A  28
SER A  31
VAL A  71
LEU A  24
 None
 1.37A 1yajB-1brlA:
undetectable		 1yajB-1brlA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1brl BACTERIAL LUCIFERASE
(Vibrio
harveyi) 		4 / 6 THR A 230
ASP A 314
THR A 198
ASP A 316
 None
 1.30A 2okcB-1brlA:
undetectable		 2okcB-1brlA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 1brl BACTERIAL LUCIFERASE
(Vibrio
harveyi) 		4 / 7 PHE A   3
GLY A  35
PHE A  36
PHE A 327
 None
 1.12A 3ko0D-1brlA:
undetectable
3ko0E-1brlA:
undetectable		 3ko0D-1brlA:
15.34
3ko0E-1brlA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 1brl BACTERIAL LUCIFERASE
(Vibrio
harveyi) 		4 / 7 PHE A 327
CYH A 324
PHE A   3
PHE A  36
 None
 0.96A 3ko0D-1brlA:
undetectable
3ko0E-1brlA:
undetectable		 3ko0D-1brlA:
15.34
3ko0E-1brlA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 1brl BACTERIAL LUCIFERASE
(Vibrio
harveyi) 		4 / 8 PHE A 327
CYH A 324
PHE A   3
PHE A  36
 None
 1.10A 3ko0B-1brlA:
undetectable
3ko0J-1brlA:
undetectable		 3ko0B-1brlA:
15.34
3ko0J-1brlA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 1brl BACTERIAL LUCIFERASE
(Vibrio
harveyi) 		4 / 7 CYH A 324
PHE A   3
PHE A  36
PHE A 327
 None
 1.08A 3ko0L-1brlA:
undetectable
3ko0N-1brlA:
undetectable		 3ko0L-1brlA:
15.34
3ko0N-1brlA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 1brl BACTERIAL LUCIFERASE
(Vibrio
harveyi) 		4 / 7 PHE A 327
CYH A 324
PHE A   3
PHE A  36
 None
 1.09A 3ko0K-1brlA:
undetectable
3ko0S-1brlA:
undetectable		 3ko0K-1brlA:
15.34
3ko0S-1brlA:
15.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUB_B_LDPB501_1
(CYTOCHROME P450 BM3
VARIANT 9D7)		 1brl BACTERIAL LUCIFERASE
(Vibrio
harveyi) 		4 / 6 ALA A  58
GLY A  28
LEU A  24
VAL A  25
 None
 0.89A 4dubB-1brlA:
0.0		 4dubB-1brlA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1brl BACTERIAL LUCIFERASE
(Vibrio
harveyi) 		4 / 8 GLN A 312
ASP A 314
ILE A 315
ASP A 321
 None
 0.85A 4kttD-1brlA:
undetectable		 4kttD-1brlA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1brl BACTERIAL LUCIFERASE
(Vibrio
harveyi) 		4 / 6 CYH A 325
ILE A 229
ILE A 311
ASP A 314
 None
 1.09A 4w5qA-1brlA:
undetectable		 4w5qA-1brlA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1brl BACTERIAL LUCIFERASE
(Vibrio
harveyi) 		4 / 6 CYH A 325
ILE A 229
ILE A 311
ASP A 314
 None
 1.13A 4w5tA-1brlA:
undetectable		 4w5tA-1brlA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1brl BACTERIAL LUCIFERASE
(Vibrio
harveyi) 		4 / 6 CYH A 325
ILE A 229
ILE A 311
ASP A 314
 None
 1.07A 4z4cA-1brlA:
undetectable		 4z4cA-1brlA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4D_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1brl BACTERIAL LUCIFERASE
(Vibrio
harveyi) 		4 / 6 CYH A 325
ILE A 229
ILE A 311
ASP A 314
 None
 1.15A 4z4dA-1brlA:
undetectable		 4z4dA-1brlA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_2
(PROTEIN CYP51)		 1brl BACTERIAL LUCIFERASE
(Vibrio
harveyi) 		4 / 7 VAL A 301
LEU A  41
PHE A 246
LEU A   8
 None
 1.08A 6aycA-1brlA:
0.0		 6aycA-1brlA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 1brl BACTERIAL LUCIFERASE
(Vibrio
harveyi) 		4 / 6 CYH A 325
ILE A 229
ILE A 311
ASP A 314
 None
 1.14A 6cbdA-1brlA:
undetectable		 6cbdA-1brlA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_B_LLLB301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1brl BACTERIAL LUCIFERASE
(Vibrio
harveyi) 		4 / 7 ASP A 293
TYR A 296
GLU A 297
GLU A 200
 None
 1.33A 6mn5B-1brlA:
0.0		 6mn5B-1brlA:
13.37