SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1brr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_2
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1brr PROTEIN
(BACTERIORHODOPSIN)
(Halobacterium
salinarum) 		4 / 4 THR A 170
LEU A 174
VAL A 177
LEU A 181
 None
 0.70A 1fbmD-1brrA:
0.0		 1fbmD-1brrA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FBM_B_RTLB951_3
(PROTEIN (CARTILAGE
OLIGOMERIC MATRIX
PROTEIN))		 1brr PROTEIN
(BACTERIORHODOPSIN)
(Halobacterium
salinarum) 		4 / 5 THR A 170
LEU A 174
VAL A 177
LEU A 181
 None
 0.75A 1fbmE-1brrA:
0.0		 1fbmE-1brrA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_D_X2ND1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1brr PROTEIN
(BACTERIORHODOPSIN)
(Halobacterium
salinarum) 		5 / 12 PHE A  27
ALA A  39
ALA A 228
THR A 170
LEU A 174
 None
 1.38A 2x2nD-1brrA:
0.1		 2x2nD-1brrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_2
(PUTATIVE ADENOSINE
KINASE)		 1brr PROTEIN
(BACTERIORHODOPSIN)
(Halobacterium
salinarum) 		4 / 5 LEU A 224
ALA A 228
THR A  46
PHE A  42
 None
 1.25A 3vasB-1brrA:
undetectable		 3vasB-1brrA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1brr PROTEIN
(BACTERIORHODOPSIN)
(Halobacterium
salinarum) 		5 / 12 GLU A 161
LEU A 152
THR A 107
ILE A 108
ARG A 175
 None
None
ARC  A1000 (-3.7A)
None
None
 1.16A 4hytA-1brrA:
3.1		 4hytA-1brrA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_C_OBNC2004_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1brr PROTEIN
(BACTERIORHODOPSIN)
(Halobacterium
salinarum) 		5 / 12 GLU A 161
LEU A 152
THR A 107
ILE A 108
ARG A 175
 None
None
ARC  A1000 (-3.7A)
None
None
 1.15A 4hytC-1brrA:
0.0		 4hytC-1brrA:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1brr PROTEIN
(BACTERIORHODOPSIN)
(Halobacterium
salinarum) 		5 / 8 ALA A 126
VAL A  69
GLY A 195
PRO A  77
ILE A  78
 None
 1.33A 4ll3A-1brrA:
0.0		 4ll3A-1brrA:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V20_A_ACTA1444_0
(CELLOBIOHYDROLASE)		 1brr PROTEIN
(BACTERIORHODOPSIN)
(Halobacterium
salinarum) 		4 / 5 GLY A   6
THR A   5
GLY A  63
GLU A   9
 None
 1.04A 4v20A-1brrA:
undetectable		 4v20A-1brrA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1brr PROTEIN
(BACTERIORHODOPSIN)
(Halobacterium
salinarum) 		5 / 12 TYR A 185
TRP A 189
ILE A 148
GLY A 116
ILE A 117
 RET  A 999 (-3.5A)
RET  A 999 ( 4.3A)
None
ARC  A1002 ( 3.8A)
ARC  A1002 (-4.6A)
 0.99A 5d4uC-1brrA:
undetectable		 5d4uC-1brrA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D4U_D_SAMD301_0
(UNCHARACTERIZED
PROTEIN MJ0489)		 1brr PROTEIN
(BACTERIORHODOPSIN)
(Halobacterium
salinarum) 		5 / 12 TYR A 185
TRP A 189
ILE A 148
GLY A 116
ILE A 117
 RET  A 999 (-3.5A)
RET  A 999 ( 4.3A)
None
ARC  A1002 ( 3.8A)
ARC  A1002 (-4.6A)
 0.95A 5d4uD-1brrA:
undetectable		 5d4uD-1brrA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 1brr PROTEIN
(BACTERIORHODOPSIN)
(Halobacterium
salinarum) 		5 / 12 LEU A 223
LEU A  93
LEU A  97
LEU A 152
LEU A 181
 None
 1.19A 5toaB-1brrA:
undetectable		 5toaB-1brrA:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1brr PROTEIN
(BACTERIORHODOPSIN)
(Halobacterium
salinarum) 		4 / 8 ILE A   4
THR A   5
GLU A 204
SER A 193
 None
 1.07A 6c06C-1brrA:
0.0		 6c06C-1brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C06_D_FI8D1404_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1brr PROTEIN
(BACTERIORHODOPSIN)
(Halobacterium
salinarum) 		4 / 8 ILE A   4
THR A   5
THR A 205
SER A 193
 None
 1.08A 6c06C-1brrA:
0.0		 6c06C-1brrA:
undetectable