SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bru'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1bru ELASTASE
(Sus
scrofa) 		5 / 8 HIS P  57
SER P 190
SER P 195
VAL P 213
GLY P 216
 1NB  P   1 (-3.9A)
1NB  P   1 (-3.5A)
1NB  P   1 ( 1.2A)
None
1NB  P   1 ( 4.4A)
 0.55A 1aq7A-1bruP:
36.3		 1aq7A-1bruP:
40.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ETR_H_MITH1_1
(EPSILON-THROMBIN)		 1bru ELASTASE
(Sus
scrofa) 		5 / 12 HIS P  57
LEU P  99
SER P 195
VAL P 213
GLY P 216
 1NB  P   1 (-3.9A)
None
1NB  P   1 ( 1.2A)
None
1NB  P   1 ( 4.4A)
 0.77A 1etrH-1bruP:
34.5		 1etrH-1bruP:
36.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1F5L_A_AMRA301_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1bru ELASTASE
(Sus
scrofa) 		4 / 8 SER P 190
SER P 195
VAL P 213
GLY P 216
 1NB  P   1 (-3.5A)
1NB  P   1 ( 1.2A)
None
1NB  P   1 ( 4.4A)
 0.45A 1f5lA-1bruP:
36.4		 1f5lA-1bruP:
36.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HXB_A_ROCA100_4
(HIV-1 PROTEASE)		 1bru ELASTASE
(Sus
scrofa) 		4 / 4 GLY P 184
ASP P 186
GLY P  18
THR P 146
 None
 0.97A 1hxbB-1bruP:
undetectable		 1hxbB-1bruP:
18.45
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1TNL_A_TPAA900_1
(TRYPSIN)		 1bru ELASTASE
(Sus
scrofa) 		4 / 6 SER P 190
SER P 195
VAL P 213
GLY P 216
 1NB  P   1 (-3.5A)
1NB  P   1 ( 1.2A)
None
1NB  P   1 ( 4.4A)
 0.48A 1tnlA-1bruP:
16.5		 1tnlA-1bruP:
40.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1bru ELASTASE
(Sus
scrofa) 		4 / 6 SER P 190
SER P 195
VAL P 213
GLY P 216
 1NB  P   1 (-3.5A)
1NB  P   1 ( 1.2A)
None
1NB  P   1 ( 4.4A)
 0.45A 2otvA-1bruP:
16.7		 2otvA-1bruP:
40.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 1bru ELASTASE
(Sus
scrofa) 		5 / 12 VAL P 213
ASP P 194
GLY P 142
ALA P 183
PHE P 228
 None
 0.83A 2v0zO-1bruP:
undetectable		 2v0zO-1bruP:
20.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VIN_A_505A1247_1
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR CHAIN B)		 1bru ELASTASE
(Sus
scrofa) 		4 / 8 SER P 190
SER P 195
VAL P 213
GLY P 216
 1NB  P   1 (-3.5A)
1NB  P   1 ( 1.2A)
None
1NB  P   1 ( 4.4A)
 0.54A 2vinA-1bruP:
37.1		 2vinA-1bruP:
36.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1bru ELASTASE
(Sus
scrofa) 		3 / 3 LEU P 105
TRP P  94
TYR P 234
 None
 1.01A 3aicE-1bruP:
undetectable		 3aicE-1bruP:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1bru ELASTASE
(Sus
scrofa) 		3 / 3 LEU P  53
TRP P  94
TYR P 234
 None
 1.01A 3aicF-1bruP:
undetectable		 3aicF-1bruP:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1bru ELASTASE
(Sus
scrofa) 		3 / 3 LEU P 105
TRP P  94
TYR P 234
 None
 1.02A 3aicF-1bruP:
undetectable		 3aicF-1bruP:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1bru ELASTASE
(Sus
scrofa) 		3 / 3 LEU P 105
TRP P  94
TYR P 234
 None
 0.99A 3aicG-1bruP:
undetectable		 3aicG-1bruP:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1bru ELASTASE
(Sus
scrofa) 		3 / 3 LEU P 105
TRP P  94
TYR P 234
 None
 1.00A 3aicH-1bruP:
undetectable		 3aicH-1bruP:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_B_SVRB512_2
(PHOSPHOLIPASE A2)		 1bru ELASTASE
(Sus
scrofa) 		4 / 7 VAL P  90
ILE P 212
GLY P 211
ARG P 230
 None
 0.76A 3bjwB-1bruP:
undetectable		 3bjwB-1bruP:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_H_SVRH511_3
(PHOSPHOLIPASE A2)		 1bru ELASTASE
(Sus
scrofa) 		4 / 7 VAL P  90
ILE P 212
GLY P 211
ARG P 230
 None
 0.78A 3bjwH-1bruP:
undetectable		 3bjwH-1bruP:
17.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1bru ELASTASE
(Sus
scrofa) 		5 / 11 HIS P  57
LEU P  99
SER P 190
SER P 195
GLY P 216
 1NB  P   1 (-3.9A)
None
1NB  P   1 (-3.5A)
1NB  P   1 ( 1.2A)
1NB  P   1 ( 4.4A)
 0.74A 3gy3A-1bruP:
16.8		 3gy3A-1bruP:
40.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_0
(O-METHYLTRANSFERASE)		 1bru ELASTASE
(Sus
scrofa) 		5 / 12 LEU P 106
GLY P  43
GLY P  44
SER P 190
ASP P 102
 None
None
None
1NB  P   1 (-3.5A)
None
 1.14A 3i5uB-1bruP:
undetectable		 3i5uB-1bruP:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 1bru ELASTASE
(Sus
scrofa) 		4 / 4 GLY P 184
ASP P 186
GLY P  18
THR P 146
 None
 1.03A 3k4vC-1bruP:
undetectable		 3k4vC-1bruP:
15.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3RXF_A_4APA9_1
(CATIONIC TRYPSIN)		 1bru ELASTASE
(Sus
scrofa) 		4 / 6 SER P 190
SER P 195
VAL P 213
GLY P 216
 1NB  P   1 (-3.5A)
1NB  P   1 ( 1.2A)
None
1NB  P   1 ( 4.4A)
 0.31A 3rxfA-1bruP:
17.6		 3rxfA-1bruP:
40.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CTK_C_SAMC1263_0
(POLYPROTEIN)		 1bru ELASTASE
(Sus
scrofa) 		6 / 12 GLY P 142
GLY P  44
GLY P 196
GLY P 193
THR P  54
VAL P  52
 None
None
None
1NB  P   1 (-3.5A)
None
None
 1.27A 4ctkC-1bruP:
undetectable		 4ctkC-1bruP:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Y_B_EF2B151_1
(CEREBLON ISOFORM 4)		 1bru ELASTASE
(Sus
scrofa) 		4 / 7 ASN P 200
PRO P 198
TRP P  27
TRP P 207
 None
 1.45A 4v2yB-1bruP:
0.0		 4v2yB-1bruP:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_A_Y70A151_1
(CEREBLON ISOFORM 4)		 1bru ELASTASE
(Sus
scrofa) 		4 / 7 ASN P 200
PRO P 198
TRP P  27
TRP P 207
 None
 1.46A 4v2zA-1bruP:
0.0		 4v2zA-1bruP:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V2Z_B_Y70B151_1
(CEREBLON ISOFORM 4)		 1bru ELASTASE
(Sus
scrofa) 		4 / 8 ASN P 200
PRO P 198
TRP P  27
TRP P 207
 None
 1.46A 4v2zB-1bruP:
0.1		 4v2zB-1bruP:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_A_LVYA151_1
(CEREBLON ISOFORM 4)		 1bru ELASTASE
(Sus
scrofa) 		4 / 7 ASN P 200
PRO P 198
TRP P  27
TRP P 207
 None
 1.42A 4v30A-1bruP:
0.0		 4v30A-1bruP:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V30_B_LVYB151_1
(CEREBLON ISOFORM 4)		 1bru ELASTASE
(Sus
scrofa) 		4 / 8 ASN P 200
PRO P 198
TRP P  27
TRP P 207
 None
 1.47A 4v30B-1bruP:
0.0		 4v30B-1bruP:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_A_EF2A151_1
(CEREBLON ISOFORM 4)		 1bru ELASTASE
(Sus
scrofa) 		4 / 7 ASN P 200
PRO P 198
TRP P  27
TRP P 207
 None
 1.46A 5amiA-1bruP:
undetectable		 5amiA-1bruP:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMK_B_EF2B151_1
(CEREBLON ISOFORM 4)		 1bru ELASTASE
(Sus
scrofa) 		4 / 7 ASN P 200
PRO P 198
TRP P  27
TRP P 207
 None
 1.47A 5amkB-1bruP:
0.0		 5amkB-1bruP:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EIW_C_SAMC4000_0
(NS5
METHYLTRANSFERASE)		 1bru ELASTASE
(Sus
scrofa) 		6 / 12 GLY P 142
GLY P  44
GLY P 196
GLY P 193
THR P  54
VAL P  52
 None
None
None
1NB  P   1 (-3.5A)
None
None
 1.26A 5eiwC-1bruP:
undetectable		 5eiwC-1bruP:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EKX_B_SAMB4000_0
(NS5
METHYLTRANSFERASE)		 1bru ELASTASE
(Sus
scrofa) 		6 / 12 GLY P 142
GLY P  44
GLY P 196
GLY P 193
THR P  54
VAL P  52
 None
None
None
1NB  P   1 (-3.5A)
None
None
 1.28A 5ekxB-1bruP:
undetectable		 5ekxB-1bruP:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1bru ELASTASE
(Sus
scrofa) 		4 / 4 ALA P 183
PRO P 198
LEU P 123
HIS P 210
 None
 1.48A 5eskA-1bruP:
undetectable		 5eskA-1bruP:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5B_A_SAMA1001_0
(NS5
METHYLTRANSFERASE)		 1bru ELASTASE
(Sus
scrofa) 		6 / 12 GLY P 142
GLY P  44
GLY P 196
GLY P 193
THR P  54
VAL P  52
 None
None
None
1NB  P   1 (-3.5A)
None
None
 1.28A 5m5bA-1bruP:
undetectable		 5m5bA-1bruP:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_A_SAMA501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1bru ELASTASE
(Sus
scrofa) 		5 / 12 LEU P  68
GLY P  79
LEU P  46
LEU P 120
LEU P 114
 None
 1.01A 5nfjA-1bruP:
undetectable		 5nfjA-1bruP:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1bru ELASTASE
(Sus
scrofa) 		5 / 12 LEU P  68
GLY P  79
LEU P  46
LEU P 120
LEU P 114
 None
 1.01A 5nfjB-1bruP:
undetectable		 5nfjB-1bruP:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_C_C2FC702_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 1bru ELASTASE
(Sus
scrofa) 		5 / 12 GLY P 100
VAL P  47
LEU P 123
GLY P 211
ILE P 212
 None
 1.19A 5vooC-1bruP:
undetectable		 5vooC-1bruP:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1bru ELASTASE
(Sus
scrofa) 		4 / 8 GLY P 216
GLY P 193
SER P 195
ALA P  55
 1NB  P   1 ( 4.4A)
1NB  P   1 (-3.5A)
1NB  P   1 ( 1.2A)
None
 0.76A 6hu9H-1bruP:
0.0
6hu9e-1bruP:
undetectable		 6hu9H-1bruP:
18.33
6hu9e-1bruP:
18.15