SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1brw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_A_SAMA105_0
(PROTEIN (MET
REPRESSOR))		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		4 / 8 GLU A 297
ARG A 293
GLU A 270
HIS A 266
 None
 0.68A 1cmaA-1brwA:
undetectable
1cmaB-1brwA:
undetectable		 1cmaA-1brwA:
15.64
1cmaB-1brwA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 11 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.83A 1cmaA-1brwA:
undetectable
1cmaB-1brwA:
undetectable		 1cmaA-1brwA:
15.64
1cmaB-1brwA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_A_SAMA105_0
(MET REPRESSOR)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 10 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.87A 1cmcA-1brwA:
undetectable
1cmcB-1brwA:
undetectable		 1cmcA-1brwA:
15.64
1cmcB-1brwA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMC_B_SAMB105_0
(MET REPRESSOR)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 10 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.81A 1cmcA-1brwA:
undetectable
1cmcB-1brwA:
undetectable		 1cmcA-1brwA:
15.64
1cmcB-1brwA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DDR_B_MTXB200_1
(DIHYDROFOLATE
REDUCTASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 148
ALA A 308
LEU A 313
PHE A 312
LEU A 124
 None
 1.21A 1ddrB-1brwA:
undetectable		 1ddrB-1brwA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX9_A_REAA1163_1
(BETA-LACTOGLOBULIN)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 11 LEU A 198
VAL A 200
ILE A 177
ILE A 180
MET A 221
 None
 1.38A 1gx9A-1brwA:
undetectable		 1gx9A-1brwA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2200_0
(PROTEIN (METHIONINE
REPRESSOR))		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 12 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.76A 1mj2A-1brwA:
undetectable
1mj2B-1brwA:
undetectable		 1mj2A-1brwA:
15.40
1mj2B-1brwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_A_SAMA2201_0
(PROTEIN (METHIONINE
REPRESSOR))		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 9 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.81A 1mj2A-1brwA:
undetectable		 1mj2A-1brwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC1200_0
(PROTEIN (METHIONINE
REPRESSOR))		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 9 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.79A 1mj2C-1brwA:
undetectable		 1mj2C-1brwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJ2_C_SAMC2199_0
(PROTEIN (METHIONINE
REPRESSOR))		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 12 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.79A 1mj2C-1brwA:
undetectable
1mj2D-1brwA:
undetectable		 1mj2C-1brwA:
15.40
1mj2D-1brwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_A_SAMA200_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 11 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.85A 1mjlA-1brwA:
undetectable
1mjlB-1brwA:
undetectable		 1mjlA-1brwA:
15.40
1mjlB-1brwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 9 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.81A 1mjlA-1brwA:
undetectable
1mjlB-1brwA:
undetectable		 1mjlA-1brwA:
15.40
1mjlB-1brwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_A_SAMA199_0
(METHIONINE REPRESSOR)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 9 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.81A 1mjoA-1brwA:
undetectable		 1mjoA-1brwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_B_SAMB200_1
(METHIONINE REPRESSOR)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 9 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.76A 1mjoB-1brwA:
undetectable		 1mjoB-1brwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_C_SAMC200_0
(METHIONINE REPRESSOR)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 12 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.79A 1mjoC-1brwA:
undetectable
1mjoD-1brwA:
undetectable		 1mjoC-1brwA:
15.40
1mjoD-1brwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJO_D_SAMD200_0
(METHIONINE REPRESSOR)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 9 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.80A 1mjoC-1brwA:
undetectable		 1mjoC-1brwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 11 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.78A 1mjqA-1brwA:
undetectable
1mjqB-1brwA:
undetectable		 1mjqA-1brwA:
15.40
1mjqB-1brwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_B_SAMB200_0
(METHIONINE REPRESSOR)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 11 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.77A 1mjqA-1brwA:
undetectable
1mjqB-1brwA:
undetectable		 1mjqA-1brwA:
15.40
1mjqB-1brwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 10 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.78A 1mjqC-1brwA:
undetectable
1mjqD-1brwA:
undetectable		 1mjqC-1brwA:
15.40
1mjqD-1brwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_D_SAMD200_0
(METHIONINE REPRESSOR)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 12 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.73A 1mjqC-1brwA:
undetectable
1mjqD-1brwA:
undetectable		 1mjqC-1brwA:
15.40
1mjqD-1brwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_H_SAMH200_0
(METHIONINE REPRESSOR)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 10 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.77A 1mjqG-1brwA:
undetectable
1mjqH-1brwA:
undetectable		 1mjqG-1brwA:
15.40
1mjqH-1brwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 11 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.77A 1mjqI-1brwA:
undetectable
1mjqJ-1brwA:
undetectable		 1mjqI-1brwA:
15.40
1mjqJ-1brwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_J_SAMJ200_0
(METHIONINE REPRESSOR)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 12 GLU A 297
ARG A 293
LEU A 273
GLU A 270
HIS A 266
 None
 0.73A 1mjqI-1brwA:
undetectable
1mjqJ-1brwA:
undetectable		 1mjqI-1brwA:
15.40
1mjqJ-1brwA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 10 GLY A  88
VAL A  87
GLY A  86
THR A  90
VAL A 247
 CA  A3001 (-3.4A)
None
None
CA  A3001 (-4.0A)
None
 1.30A 1pwyE-1brwA:
undetectable		 1pwyE-1brwA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RE7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 148
LEU A 313
PHE A 312
THR A 120
ILE A 150
 None
None
None
PO4  A2001 ( 3.4A)
None
 1.14A 1re7A-1brwA:
undetectable		 1re7A-1brwA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UPF_C_URFC999_1
(URACIL
PHOSPHORIBOSYLTRANSF
ERASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		4 / 5 ALA A 214
TYR A 429
ILE A 236
ASP A 238
 None
 1.04A 1upfC-1brwA:
undetectable		 1upfC-1brwA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		3 / 3 ASP A 352
GLU A 213
TYR A 429
 None
 0.69A 1wsvA-1brwA:
undetectable		 1wsvA-1brwA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 9 GLY A 147
GLU A 145
ASN A 144
ILE A  74
ALA A 107
 None
 1.28A 2drdA-1brwA:
0.0		 2drdA-1brwA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A164_1
(BETA-LACTOGLOBULIN)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		4 / 5 ASP A 212
LEU A 211
LYS A 210
ARG A 215
 None
 1.28A 2gj5A-1brwA:
0.0		 2gj5A-1brwA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_1
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		4 / 6 THR A 202
THR A  84
ASP A  89
THR A  91
 None
 1.19A 2okcB-1brwA:
undetectable		 2okcB-1brwA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_A_KLNA1501_1
(CYTOCHROME P450 3A4)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 10 SER A 110
ILE A 121
LEU A 361
ILE A 150
GLY A  88
 PO4  A2001 ( 3.2A)
None
None
None
CA  A3001 (-3.4A)
 1.11A 2v0mA-1brwA:
0.0		 2v0mA-1brwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		4 / 7 PHE A 207
ILE A 121
ILE A 150
GLY A  85
 None
 0.89A 2v0mB-1brwA:
0.0		 2v0mB-1brwA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 12 GLY A  88
LEU A 361
GLY A 377
GLY A 248
SER A 399
 CA  A3001 (-3.4A)
None
None
None
None
 1.09A 2zbpA-1brwA:
undetectable		 2zbpA-1brwA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE503_1
(PHOSPHOLIPASE A2)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 11 VAL A  94
LEU A  95
GLY A  96
ILE A 148
THR A 120
 None
None
None
None
PO4  A2001 ( 3.4A)
 1.35A 3bjwE-1brwA:
0.0		 3bjwE-1brwA:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_D_MTXD164_1
(DIHYDROFOLATE
REDUCTASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 12 ILE A 148
ALA A 308
LEU A 313
PHE A 312
LEU A 124
 None
 1.14A 3ia4D-1brwA:
undetectable		 3ia4D-1brwA:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		4 / 4 ARG A 168
ASP A 352
GLY A 203
THR A  84
 None
 1.41A 3k4vB-1brwA:
undetectable		 3k4vB-1brwA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PRS_A_RITA1001_1
(ENDOTHIAPEPSIN)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 10 ASP A 267
ILE A 184
ILE A 121
THR A  90
ILE A 150
 None
None
None
CA  A3001 (-4.0A)
None
 1.19A 3prsA-1brwA:
0.0		 3prsA-1brwA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		4 / 8 ASP A 122
ARG A 365
GLY A 152
GLN A 153
 None
 0.89A 4af0A-1brwA:
undetectable		 4af0A-1brwA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I1N_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 11 ILE A 148
ALA A 308
LEU A 313
PHE A 312
LEU A 124
 None
 1.24A 4i1nA-1brwA:
undetectable		 4i1nA-1brwA:
16.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		7 / 11 THR A  84
ARG A 168
ILE A 180
SER A 183
LYS A 187
MET A 208
LEU A 217
 None
 0.78A 4lhmA-1brwA:
55.3		 4lhmA-1brwA:
43.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 11 THR A  84
LYS A 187
PHE A 207
MET A 208
LEU A 217
 None
 0.98A 4lhmA-1brwA:
55.3		 4lhmA-1brwA:
43.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 11 THR A  84
SER A 182
PHE A 207
MET A 208
LEU A 217
 None
 0.89A 4lhmA-1brwA:
55.3		 4lhmA-1brwA:
43.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		8 / 11 THR A  84
TYR A 165
ARG A 168
VAL A 174
ILE A 180
SER A 183
LYS A 187
LEU A 217
 None
 0.66A 4lhmA-1brwA:
55.3		 4lhmA-1brwA:
43.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LHM_A_AZZA510_1
(THYMIDINE
PHOSPHORYLASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 11 THR A  84
TYR A 165
LYS A 187
PHE A 207
LEU A 217
 None
 1.17A 4lhmA-1brwA:
55.3		 4lhmA-1brwA:
43.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		6 / 12 ILE A 148
ALA A 308
LEU A 313
ALA A 314
PHE A 312
LEU A 124
 None
 1.19A 4pssA-1brwA:
undetectable		 4pssA-1brwA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		6 / 12 ILE A 148
LEU A 313
ALA A 314
PHE A 312
LEU A 124
ILE A 150
 None
 1.31A 4pssA-1brwA:
undetectable		 4pssA-1brwA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		6 / 12 ILE A 148
LEU A 313
ALA A 314
PHE A 312
THR A 120
ILE A 150
 None
None
None
None
PO4  A2001 ( 3.4A)
None
 1.27A 4pssA-1brwA:
undetectable		 4pssA-1brwA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSS_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		6 / 12 LEU A 313
ALA A 314
PHE A 312
THR A  92
LEU A 124
ILE A 150
 None
None
None
PO4  A2001 (-3.3A)
None
None
 1.48A 4pssA-1brwA:
undetectable		 4pssA-1brwA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZF8_A_MYTA502_1
(BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		4 / 6 LEU A 326
ILE A 257
ALA A 256
ALA A 246
 None
None
None
CA  A3001 (-4.6A)
 0.76A 4zf8A-1brwA:
0.0		 4zf8A-1brwA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_D_PAUD601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		4 / 8 VAL A 407
ALA A 357
GLY A 355
GLY A 364
 None
 0.87A 5e26C-1brwA:
2.1
5e26D-1brwA:
1.7		 5e26C-1brwA:
23.33
5e26D-1brwA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FPD_B_PZAB1385_0
(HEAT SHOCK-RELATED
70KDA PROTEIN 2)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 7 VAL A 322
SER A 321
ALA A 320
GLY A 318
VAL A 127
 None
 1.40A 5fpdB-1brwA:
2.2		 5fpdB-1brwA:
24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JMN_B_FUAB1101_1
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		4 / 5 ILE A 236
LEU A 275
LYS A  81
HIS A  82
 None
None
PO4  A2001 ( 2.6A)
PO4  A2001 (-4.1A)
 1.21A 5jmnB-1brwA:
0.0		 5jmnB-1brwA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M78_A_SALA304_1
(CARBONIC ANHYDRASE 2)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		4 / 7 VAL A 197
LEU A  95
THR A  92
THR A  91
 None
None
PO4  A2001 (-3.3A)
None
 0.74A 5m78A-1brwA:
undetectable		 5m78A-1brwA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		4 / 4 GLY A 192
ALA A 190
MET A 109
THR A 158
 None
 1.22A 5n0sB-1brwA:
0.5		 5n0sB-1brwA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 193
PRO A 105
GLY A  76
LYS A 108
ALA A 191
 None
None
None
PO4  A2001 ( 2.8A)
None
 1.12A 5zvgA-1brwA:
undetectable		 5zvgA-1brwA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 12 ALA A 193
PRO A 105
GLY A  76
LYS A 108
ALA A 191
 None
None
None
PO4  A2001 ( 2.8A)
None
 1.10A 5zvgB-1brwA:
undetectable		 5zvgB-1brwA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 12 HIS A 131
LEU A  93
VAL A 253
PHE A 309
GLY A 317
 None
 1.24A 6brdA-1brwA:
2.7		 6brdA-1brwA:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F5U_A_CQNA610_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1brw PROTEIN (PYRIMIDINE
NUCLEOSIDE
PHOSPHORYLASE)
(Geobacillus
stearothermophil
us) 		5 / 10 VAL A 253
ALA A 256
LEU A 313
LEU A 326
LEU A 329
 None
 0.97A 6f5uA-1brwA:
0.0
6f5uB-1brwA:
undetectable		 6f5uA-1brwA:
12.25
6f5uB-1brwA:
12.00