SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bry'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1bry BRYODIN I
(Bryonia
dioica) 		5 / 12 VAL Y 232
LEU Y 195
SER Y 193
LEU Y 241
GLU Y 160
 None
 1.42A 1mmkA-1bryY:
undetectable		 1mmkA-1bryY:
22.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 1bry BRYODIN I
(Bryonia
dioica) 		8 / 9 ILE Y  71
PHE Y  83
GLY Y 109
TYR Y 111
ILE Y 155
ALA Y 159
GLU Y 160
ARG Y 163
 None
 0.33A 1mrgA-1bryY:
41.0		 1mrgA-1bryY:
66.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 1bry BRYODIN I
(Bryonia
dioica) 		5 / 9 TYR Y  70
TYR Y 111
ILE Y 155
ALA Y 159
GLU Y 160
 None
 1.11A 1mrgA-1bryY:
41.0		 1mrgA-1bryY:
66.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 1bry BRYODIN I
(Bryonia
dioica) 		6 / 8 ILE Y  71
GLY Y 109
TYR Y 111
ILE Y 155
GLU Y 160
ARG Y 163
 None
 0.27A 1mrjA-1bryY:
43.2		 1mrjA-1bryY:
86.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDU_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 1bry BRYODIN I
(Bryonia
dioica) 		5 / 11 LEU Y 215
ALA Y 230
GLY Y 207
VAL Y 213
ILE Y 225
 None
 1.04A 1sduA-1bryY:
undetectable		 1sduA-1bryY:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_1
(RETINOIC ACID
RECEPTOR, BETA)		 1bry BRYODIN I
(Bryonia
dioica) 		5 / 12 LEU Y 139
LEU Y 154
ILE Y 155
PHE Y  83
LEU Y 105
 None
 1.01A 1xdkF-1bryY:
0.1		 1xdkF-1bryY:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9G_A_TOPA1159_1
(DIHYDROFOLATE
REDUCTASE)		 1bry BRYODIN I
(Bryonia
dioica) 		5 / 10 LEU Y 151
ALA Y 135
LEU Y 132
LEU Y  52
SER Y 161
 None
 1.14A 2w9gA-1bryY:
undetectable		 2w9gA-1bryY:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1bry BRYODIN I
(Bryonia
dioica) 		5 / 10 TYR Y  14
ALA Y 162
ALA Y 159
LEU Y 154
VAL Y  62
 None
 1.39A 2wuzA-1bryY:
undetectable		 2wuzA-1bryY:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1bry BRYODIN I
(Bryonia
dioica) 		5 / 10 TYR Y  14
ALA Y 162
ALA Y 159
LEU Y 154
VAL Y  62
 None
 1.36A 2wuzB-1bryY:
undetectable		 2wuzB-1bryY:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL0_A_1UNA201_2
(PROTEASE)		 1bry BRYODIN I
(Bryonia
dioica) 		5 / 9 LEU Y  49
VAL Y  66
ILE Y  41
GLY Y  43
ALA Y  63
 None
 1.03A 3el0B-1bryY:
undetectable		 3el0B-1bryY:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 1bry BRYODIN I
(Bryonia
dioica) 		3 / 3 GLU Y 112
GLU Y 189
ASN Y 190
 None
 0.91A 3lp9B-1bryY:
0.3
3lp9D-1bryY:
0.1		 3lp9B-1bryY:
22.02
3lp9D-1bryY:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 1bry BRYODIN I
(Bryonia
dioica) 		10 / 10 TYR Y  70
ILE Y  71
GLU Y  85
SER Y 108
ASN Y 110
TYR Y 111
ILE Y 155
ALA Y 159
GLU Y 160
ARG Y 163
 None
 0.55A 3u6tA-1bryY:
41.8		 3u6tA-1bryY:
66.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQB_A_FK5A114_1
(UBIQUITIN-LIKE
PROTEIN SMT3,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE)		 1bry BRYODIN I
(Bryonia
dioica) 		4 / 8 PHE Y 209
VAL Y 233
ILE Y 237
TYR Y 164
 None
 0.85A 3uqbA-1bryY:
undetectable		 3uqbA-1bryY:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA502_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 1bry BRYODIN I
(Bryonia
dioica) 		4 / 8 THR Y  48
LEU Y  25
VAL Y  69
VAL Y  64
 None
 1.00A 4em2A-1bryY:
0.0		 4em2A-1bryY:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)		 1bry BRYODIN I
(Bryonia
dioica) 		5 / 12 LEU Y  52
PHE Y  17
ALA Y   9
GLY Y 128
LEU Y 129
 None
 1.24A 4j7xB-1bryY:
undetectable		 4j7xB-1bryY:
21.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 1bry BRYODIN I
(Bryonia
dioica) 		5 / 5 TYR Y  70
ILE Y  71
ASN Y 110
TYR Y 111
ILE Y 155
 None
 0.59A 4jtpA-1bryY:
41.7		 4jtpA-1bryY:
66.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 1bry BRYODIN I
(Bryonia
dioica) 		5 / 5 TYR Y  70
ASN Y 110
TYR Y 111
ILE Y 155
ARG Y 163
 None
 0.68A 4o0oA-1bryY:
41.6		 4o0oA-1bryY:
66.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1bry BRYODIN I
(Bryonia
dioica) 		3 / 3 ASN Y  84
PHE Y  82
TYR Y  74
 None
 0.77A 4u15A-1bryY:
0.0		 4u15A-1bryY:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_A_BQ1A1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1bry BRYODIN I
(Bryonia
dioica) 		3 / 3 GLU Y  90
ALA Y  91
PHE Y  94
 None
 0.57A 4v1fA-1bryY:
undetectable		 4v1fA-1bryY:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_C_BQ1C1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1bry BRYODIN I
(Bryonia
dioica) 		3 / 3 GLU Y  90
ALA Y  91
PHE Y  94
 None
 0.60A 4v1fC-1bryY:
undetectable		 4v1fC-1bryY:
17.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1bry BRYODIN I
(Bryonia
dioica) 		9 / 9 TYR Y  70
ILE Y  71
PHE Y  83
GLY Y 109
TYR Y 111
ILE Y 155
ALA Y 159
GLU Y 160
ARG Y 163
 None
 0.59A 4yp2B-1bryY:
41.6		 4yp2B-1bryY:
67.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_C_ACTC1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 1bry BRYODIN I
(Bryonia
dioica) 		3 / 3 TYR Y 141
THR Y 143
THR Y 137
 None
 0.64A 5aoxB-1bryY:
0.0		 5aoxB-1bryY:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AOX_F_ACTF1001_0
(ALU JO CONSENSUS RNA
SIGNAL RECOGNITION
PARTICLE 14 KDA
PROTEIN)		 1bry BRYODIN I
(Bryonia
dioica) 		3 / 3 TYR Y 141
THR Y 143
THR Y 137
 None
 0.66A 5aoxE-1bryY:
0.0		 5aoxE-1bryY:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1bry BRYODIN I
(Bryonia
dioica) 		9 / 9 TYR Y  70
ILE Y  71
PHE Y  83
GLY Y 109
TYR Y 111
ILE Y 155
ALA Y 159
GLU Y 160
ARG Y 163
 None
 0.56A 5cf9B-1bryY:
41.7		 5cf9B-1bryY:
67.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 1bry BRYODIN I
(Bryonia
dioica) 		5 / 6 TYR Y  70
TYR Y 111
ILE Y 155
GLU Y 160
ARG Y 163
 None
 0.59A 5z3jA-1bryY:
34.6		 5z3jA-1bryY:
32.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 1bry BRYODIN I
(Bryonia
dioica) 		3 / 3 TYR Y  70
ALA Y 162
LEU Y 239
 None
 0.65A 6ag0C-1bryY:
undetectable		 6ag0C-1bryY:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 1bry BRYODIN I
(Bryonia
dioica) 		4 / 8 LEU Y 188
VAL Y 213
LEU Y 215
ILE Y 225
 None
 0.92A 6cb4A-1bryY:
undetectable		 6cb4A-1bryY:
21.96