SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bs0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		4 / 8 HIS A 133
SER A 179
LYS A 236
ARG A 361
 None
None
SO4  A 400 ( 3.0A)
None
 1.23A 1eqbA-1bs0A:
28.8
1eqbB-1bs0A:
28.8		 1eqbA-1bs0A:
24.22
1eqbB-1bs0A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		4 / 8 HIS A 133
SER A 179
LYS A 236
ARG A 361
 None
None
SO4  A 400 ( 3.0A)
None
 1.24A 1eqbA-1bs0A:
28.8
1eqbB-1bs0A:
28.8		 1eqbA-1bs0A:
24.22
1eqbB-1bs0A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		4 / 8 HIS A 133
SER A 179
LYS A 236
ARG A 361
 None
None
SO4  A 400 ( 3.0A)
None
 1.23A 1eqbC-1bs0A:
28.9
1eqbD-1bs0A:
28.9		 1eqbC-1bs0A:
24.22
1eqbD-1bs0A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		4 / 8 HIS A 133
SER A 179
LYS A 236
ARG A 361
 None
None
SO4  A 400 ( 3.0A)
None
 1.24A 1eqbC-1bs0A:
28.9
1eqbD-1bs0A:
28.9		 1eqbC-1bs0A:
24.22
1eqbD-1bs0A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK3_A_T44A3003_1
(SERUM ALBUMIN)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		3 / 4 LYS A 294
ALA A 297
MET A 370
 None
 1.06A 1hk3A-1bs0A:
0.0		 1hk3A-1bs0A:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_A_D16A414_1
(THYMIDYLATE SYNTHASE)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		5 / 12 ILE A 283
ASP A  48
GLY A 239
PHE A 238
ALA A 367
 None
 1.10A 1hvyA-1bs0A:
0.0		 1hvyA-1bs0A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_B_D16B415_1
(THYMIDYLATE SYNTHASE)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		5 / 12 ILE A 283
ASP A  48
GLY A 239
PHE A 238
ALA A 367
 None
 1.15A 1hvyB-1bs0A:
0.0		 1hvyB-1bs0A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HVY_D_D16D417_1
(THYMIDYLATE SYNTHASE)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		5 / 12 ILE A 283
ASP A  48
GLY A 239
PHE A 238
ALA A 367
 None
 1.08A 1hvyD-1bs0A:
0.0		 1hvyD-1bs0A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IEP_B_STIB202_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		4 / 7 VAL A 240
VAL A 232
ILE A 283
LEU A 246
 None
 0.86A 1iepB-1bs0A:
undetectable		 1iepB-1bs0A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		4 / 8 VAL A 251
TYR A 254
ILE A 263
LEU A 103
 None
 0.86A 1igxA-1bs0A:
0.0		 1igxA-1bs0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		3 / 3 LEU A 276
PHE A 234
ARG A 101
 None
 0.81A 1xdkB-1bs0A:
0.0		 1xdkB-1bs0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_F_9CRF1600_2
(RETINOIC ACID
RECEPTOR, BETA)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		3 / 3 LEU A 276
PHE A 234
ARG A 101
 None
 0.82A 1xdkF-1bs0A:
undetectable		 1xdkF-1bs0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CP4_A_CAMA416_0
(CYTOCHROME P450-CAM)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		5 / 10 THR A 209
GLY A 242
VAL A 231
ASP A 204
VAL A 232
 None
 1.38A 2cp4A-1bs0A:
0.0		 2cp4A-1bs0A:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		3 / 3 SER A 318
ARG A 303
GLN A 321
 None
 1.01A 2xnrA-1bs0A:
1.1		 2xnrA-1bs0A:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LXI_B_CAMB423_0
(CYTOCHROME P450)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		5 / 11 THR A 209
GLY A 242
VAL A 231
ASP A 204
VAL A 232
 None
 1.31A 3lxiB-1bs0A:
0.0		 3lxiB-1bs0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9N_B_CAMB1420_0
(CYTOCHROME P450)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		5 / 10 THR A 209
GLY A 242
VAL A 231
ASP A 204
VAL A 232
 None
 1.34A 4c9nB-1bs0A:
0.0		 4c9nB-1bs0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9P_B_CAMB423_0
(CYTOCHROME P450)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		5 / 10 THR A 209
GLY A 242
VAL A 231
ASP A 204
VAL A 232
 None
 1.35A 4c9pB-1bs0A:
undetectable		 4c9pB-1bs0A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_A_D16A402_1
(THYMIDYLATE SYNTHASE)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		5 / 12 ILE A 283
ASP A  48
GLY A 239
PHE A 238
ALA A 367
 None
 1.06A 4eb4A-1bs0A:
0.0		 4eb4A-1bs0A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		5 / 12 ILE A 283
ASP A  48
GLY A 239
PHE A 238
ALA A 367
 None
 1.07A 4eb4B-1bs0A:
0.0		 4eb4B-1bs0A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_2
(PROTEASE)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		5 / 12 VAL A 177
GLY A 213
GLY A 237
ILE A 212
ILE A 283
 None
 0.99A 4q5mA-1bs0A:
undetectable		 4q5mA-1bs0A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QB9_A_PARA500_1
(ENHANCED
INTRACELLULAR
SURVIVAL PROTEIN)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		5 / 10 SER A 241
THR A 233
ASP A 205
ASP A 204
GLY A 108
 None
SO4  A 400 ( 4.1A)
None
None
SO4  A 400 (-3.3A)
 1.27A 4qb9A-1bs0A:
0.0		 4qb9A-1bs0A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WRY_A_URFA302_1
(URACIL-DNA
GLYCOSYLASE)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		4 / 8 GLY A  31
SER A  46
ASN A  43
HIS A  54
 None
 0.97A 4wryA-1bs0A:
undetectable		 4wryA-1bs0A:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_B_DIFB501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		4 / 8 ILE A  58
ARG A 284
LEU A  93
ILE A 283
 None
 0.95A 4xtaB-1bs0A:
0.0		 4xtaB-1bs0A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUM_A_IMNA502_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		4 / 7 ILE A  58
ARG A 284
LEU A  93
ILE A 283
 None
 0.98A 4xumA-1bs0A:
0.2		 4xumA-1bs0A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLC_A_1YNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		5 / 12 ALA A 134
ILE A  58
GLY A  51
THR A 365
HIS A 207
 None
 1.36A 5jlcA-1bs0A:
0.3		 5jlcA-1bs0A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		5 / 12 HIS A 133
SER A 179
THR A 233
SER A  46
THR A 363
 None
None
SO4  A 400 ( 4.1A)
None
None
 1.34A 5l5zH-1bs0A:
undetectable
5l5zN-1bs0A:
undetectable		 5l5zH-1bs0A:
19.59
5l5zN-1bs0A:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		4 / 6 ASP A  48
LEU A  52
GLY A 239
PHE A 238
 None
 1.05A 5nooC-1bs0A:
0.0		 5nooC-1bs0A:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X5Q_B_D16B402_1
(THYMIDYLATE SYNTHASE)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		5 / 12 ASP A  48
LEU A  52
GLY A 239
PHE A 238
ALA A 366
 None
 1.16A 5x5qB-1bs0A:
0.0		 5x5qB-1bs0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_A_MTXA402_1
(THYMIDYLATE SYNTHASE)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		5 / 12 ILE A 283
ASP A  48
GLY A 239
PHE A 238
ALA A 367
 None
 1.00A 5x66A-1bs0A:
0.0
5x66B-1bs0A:
0.0		 5x66A-1bs0A:
20.62
5x66B-1bs0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_C_MTXC402_1
(THYMIDYLATE SYNTHASE)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		5 / 9 ILE A 283
ASP A  48
GLY A 239
PHE A 238
ALA A 367
 None
 1.00A 5x66C-1bs0A:
0.0		 5x66C-1bs0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_D_MTXD402_1
(THYMIDYLATE SYNTHASE)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		5 / 10 ILE A 283
ASP A  48
GLY A 239
PHE A 238
ALA A 367
 None
 1.01A 5x66D-1bs0A:
0.0		 5x66D-1bs0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		5 / 12 ILE A 283
ASP A  48
GLY A 239
PHE A 238
ALA A 367
 None
 1.00A 5x66F-1bs0A:
0.0		 5x66F-1bs0A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F88_B_STRB502_1
(CYTOCHROME P450
CYP260A1)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		5 / 6 LEU A 187
ALA A 185
LEU A 230
SER A 219
ASN A 112
 None
 1.14A 6f88B-1bs0A:
0.0		 6f88B-1bs0A:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 1bs0 PROTEIN
(8-AMINO-7-OXONANOAT
E SYNTHASE)
(Escherichia
coli) 		3 / 3 HIS A 207
ARG A 361
ILE A 320
 None
 0.73A 6fgdA-1bs0A:
2.2		 6fgdA-1bs0A:
20.67