SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bt2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B2I_A_AMHA84_1
(PROTEIN
(PLASMINOGEN))		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 7 TYR A  38
TRP A 120
PHE A 124
ARG A 127
 None
 1.45A 1b2iA-1bt2A:
undetectable		 1b2iA-1bt2A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 ARG A 279
ALA A  51
ASP A 146
GLY A 150
 None
 1.09A 1e7bA-1bt2A:
0.1		 1e7bA-1bt2A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 8 GLY A 212
GLY A 233
PHE A 217
LEU A 218
SER A 234
 None
 1.34A 1jhvA-1bt2A:
undetectable		 1jhvA-1bt2A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_H_FUAH709_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 12 PHE A 115
PHE A 270
VAL A 277
ALA A 232
HIS A 109
 None
C2O  A 500 ( 4.8A)
None
None
C2O  A 500 ( 3.3A)
 1.24A 1q23H-1bt2A:
0.0
1q23I-1bt2A:
0.0		 1q23H-1bt2A:
19.57
1q23I-1bt2A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IT4_A_PPFA500_1
(CARBONIC ANHYDRASE 1)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 8 HIS A  88
HIS A 274
HIS A 118
VAL A 108
HIS A 244
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
C2O  A 500 ( 3.2A)
 1.45A 2it4A-1bt2A:
undetectable		 2it4A-1bt2A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		3 / 3 LEU A 153
ASN A 158
ARG A 169
 None
 0.86A 2qhfA-1bt2A:
0.0		 2qhfA-1bt2A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 9 PHE A  63
ALA A  64
VAL A  67
GLU A  68
 None
 0.42A 2vufA-1bt2A:
0.5		 2vufA-1bt2A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WKO_F_CUF154_0
(SUPEROXIDE DISMUTASE
[CU-ZN])		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A 240
HIS A 244
VAL A 277
HIS A 274
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
C2O  A 500 ( 3.2A)
 0.89A 2wkoF-1bt2A:
undetectable		 2wkoF-1bt2A:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_C_DVAC8_0
(GRAMICIDIN A)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		3 / 3 VAL A 108
TRP A 301
TRP A 112
 None
 1.06A 2xdcC-1bt2A:
undetectable
2xdcD-1bt2A:
undetectable		 2xdcC-1bt2A:
3.92
2xdcD-1bt2A:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.21A 2zweA-1bt2A:
20.9
2zweB-1bt2A:
undetectable		 2zweA-1bt2A:
26.67
2zweB-1bt2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWE_B_DAHB98_1
(TYROSINASE
MELC)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
ILE A 241
HIS A 244
HIS A  88
HIS A 109
 C2O  A 500 ( 3.2A)
None
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
 1.12A 2zweA-1bt2A:
20.9
2zweB-1bt2A:
undetectable		 2zweA-1bt2A:
26.67
2zweB-1bt2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.25A 2zwfA-1bt2A:
20.9
2zwfB-1bt2A:
undetectable		 2zwfA-1bt2A:
26.67
2zwfB-1bt2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
PRO A  19
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.23A 2zwfA-1bt2A:
20.9
2zwfB-1bt2A:
undetectable		 2zwfA-1bt2A:
26.67
2zwfB-1bt2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWF_B_DAHB98_1
(TYROSINASE
MELC)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
ILE A 241
HIS A 244
HIS A  88
HIS A 109
 C2O  A 500 ( 3.2A)
None
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
 1.14A 2zwfA-1bt2A:
20.9
2zwfB-1bt2A:
undetectable		 2zwfA-1bt2A:
26.67
2zwfB-1bt2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.25A 2zwgA-1bt2A:
20.9
2zwgB-1bt2A:
undetectable		 2zwgA-1bt2A:
26.67
2zwgB-1bt2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZWG_B_DAHB98_1
(TYROSINASE
MELC)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
PRO A  19
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.21A 2zwgA-1bt2A:
20.9
2zwgB-1bt2A:
undetectable		 2zwgA-1bt2A:
26.67
2zwgB-1bt2A:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_2
(RENIN)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 TYR A 309
ALA A  90
TYR A  82
MET A  70
 None
 1.21A 3d91A-1bt2A:
0.0		 3d91A-1bt2A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 6 PRO A  29
LEU A 307
ALA A  32
PRO A  30
 None
 1.32A 3gv1A-1bt2A:
undetectable
3gv1C-1bt2A:
undetectable		 3gv1A-1bt2A:
15.65
3gv1C-1bt2A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 6 LEU A 307
ALA A  32
PRO A  30
PRO A  29
 None
 1.29A 3gv1A-1bt2A:
undetectable
3gv1B-1bt2A:
0.0		 3gv1A-1bt2A:
15.65
3gv1B-1bt2A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB303_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 LEU A 307
ALA A  32
VAL A  31
PRO A  30
 None
 1.16A 3gv1B-1bt2A:
undetectable		 3gv1B-1bt2A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 GLY A 219
LYS A 220
GLU A 215
GLY A 231
 None
 1.06A 3onnA-1bt2A:
undetectable		 3onnA-1bt2A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_A_CUA602_0
(LACCASE-1)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		3 / 3 HIS A 109
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.24A 3qpkA-1bt2A:
undetectable		 3qpkA-1bt2A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QPK_B_CUB602_0
(LACCASE-1)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		3 / 3 HIS A 109
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.25A 3qpkB-1bt2A:
undetectable		 3qpkB-1bt2A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		3 / 3 VAL A 108
TRP A 301
TRP A 112
 None
 1.08A 3zq8A-1bt2A:
undetectable
3zq8B-1bt2A:
undetectable		 3zq8A-1bt2A:
3.92
3zq8B-1bt2A:
3.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_F_SASF805_1
(SEPIAPTERIN
REDUCTASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 12 PHE A 270
ASP A 267
ASP A 257
MET A 258
GLY A 259
 C2O  A 500 ( 4.8A)
None
None
None
None
 1.28A 4j7xF-1bt2A:
undetectable		 4j7xF-1bt2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		3 / 3 LEU A  40
PRO A  41
ARG A  49
 None
 0.67A 4klrB-1bt2A:
undetectable		 4klrB-1bt2A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		3 / 3 PRO A 337
ASN A 144
HIS A  53
 None
 0.91A 4ma3H-1bt2A:
0.0
4ma3L-1bt2A:
0.0		 4ma3H-1bt2A:
18.23
4ma3L-1bt2A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 7 PHE A 117
HIS A 118
PHE A 261
ASN A  93
 None
C2O  A 500 ( 3.3A)
C2O  A 500 (-3.6A)
None
 1.35A 4o7gA-1bt2A:
0.2
4o7gB-1bt2A:
0.5		 4o7gA-1bt2A:
19.82
4o7gB-1bt2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_A_ASCA303_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 7 PHE A 261
HIS A 244
ILE A 241
PHE A 114
 C2O  A 500 (-3.6A)
C2O  A 500 ( 3.2A)
None
None
 1.19A 4o7gA-1bt2A:
0.2
4o7gB-1bt2A:
0.5		 4o7gA-1bt2A:
19.82
4o7gB-1bt2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 6 PHE A 117
HIS A 118
PHE A 261
ASN A  93
 None
C2O  A 500 ( 3.3A)
C2O  A 500 (-3.6A)
None
 1.34A 4o7gB-1bt2A:
0.5		 4o7gB-1bt2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O7G_B_ASCB304_0
(PROBABLE
TRANSMEMBRANE
ASCORBATE
FERRIREDUCTASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 6 PHE A 261
HIS A 244
ILE A 241
PHE A 114
 C2O  A 500 (-3.6A)
C2O  A 500 ( 3.2A)
None
None
 1.13A 4o7gB-1bt2A:
0.5		 4o7gB-1bt2A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_A_DAHA305_1
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 7 HIS A  88
HIS A 109
HIS A 240
HIS A 244
ALA A 264
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 0.55A 4p6sA-1bt2A:
21.1		 4p6sA-1bt2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6S_B_DAHB305_1
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 7 HIS A  88
HIS A 109
HIS A 240
HIS A 244
ARG A 245
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 0.89A 4p6sB-1bt2A:
21.1		 4p6sB-1bt2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XEY_B_1N1B601_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		3 / 3 MET A 329
ASP A 278
PHE A 142
 None
 0.98A 4xeyB-1bt2A:
undetectable		 4xeyB-1bt2A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EB3_A_UEGA202_1
(YFIR)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 LEU A 164
ILE A 268
PRO A 141
LEU A 129
 None
 1.24A 5eb3A-1bt2A:
undetectable		 5eb3A-1bt2A:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_A_HQEA303_1
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 7 HIS A  88
HIS A 109
HIS A 240
HIS A 244
ALA A 264
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 0.49A 5i3aA-1bt2A:
21.4		 5i3aA-1bt2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3A_B_HQEB304_1
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 7 HIS A  88
HIS A 109
HIS A 240
HIS A 244
ALA A 264
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 0.48A 5i3aB-1bt2A:
21.4		 5i3aB-1bt2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 7 HIS A  88
HIS A 109
HIS A 240
HIS A 244
ALA A 264
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 0.52A 5i3bA-1bt2A:
21.5		 5i3bA-1bt2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 7 HIS A 244
HIS A 240
HIS A 109
HIS A  88
ALA A 264
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
None
 1.10A 5i3bA-1bt2A:
21.5		 5i3bA-1bt2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_A_HQEA303_1
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 7 HIS A 244
HIS A 240
HIS A 118
HIS A  88
ALA A 264
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
None
 1.49A 5i3bA-1bt2A:
21.5		 5i3bA-1bt2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A  88
HIS A 109
HIS A 244
ALA A 264
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
None
 0.46A 5i3bB-1bt2A:
21.5		 5i3bB-1bt2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A 244
HIS A 240
HIS A  88
ALA A 264
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 0.92A 5i3bB-1bt2A:
21.5		 5i3bB-1bt2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I3B_B_HQEB303_1
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A 244
HIS A 274
HIS A  88
ALA A 264
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 1.01A 5i3bB-1bt2A:
21.5		 5i3bB-1bt2A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M8R_C_MMSC516_1
(5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 8 HIS A 109
HIS A 240
HIS A 244
GLY A 259
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 0.45A 5m8rC-1bt2A:
16.8		 5m8rC-1bt2A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHW_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.88A 5mhwA-1bt2A:
undetectable		 5mhwA-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHX_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.88A 5mhxA-1bt2A:
undetectable		 5mhxA-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHY_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.88A 5mhyA-1bt2A:
undetectable		 5mhyA-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MHZ_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.87A 5mhzA-1bt2A:
undetectable		 5mhzA-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI1_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.87A 5mi1A-1bt2A:
undetectable		 5mi1A-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MI2_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.87A 5mi2A-1bt2A:
undetectable		 5mi2A-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIA_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.87A 5miaA-1bt2A:
undetectable		 5miaA-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIB_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.87A 5mibA-1bt2A:
undetectable		 5mibA-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIC_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.86A 5micA-1bt2A:
undetectable		 5micA-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MID_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.87A 5midA-1bt2A:
undetectable		 5midA-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIE_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 109
HIS A 274
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.87A 5mieA-1bt2A:
undetectable		 5mieA-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIG_A_CUA601_0
(LACCASE 2)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		3 / 3 HIS A 109
HIS A 118
HIS A  88
 C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
 0.24A 5migA-1bt2A:
undetectable		 5migA-1bt2A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.21A 5z0fA-1bt2A:
20.9
5z0fB-1bt2A:
0.0		 5z0fA-1bt2A:
13.04
5z0fB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
PRO A  19
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.22A 5z0fA-1bt2A:
20.9
5z0fB-1bt2A:
0.0		 5z0fA-1bt2A:
13.04
5z0fB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
ILE A 241
HIS A 244
HIS A  88
HIS A 109
 C2O  A 500 ( 3.2A)
None
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
 1.14A 5z0fA-1bt2A:
20.9
5z0fB-1bt2A:
0.0		 5z0fA-1bt2A:
13.04
5z0fB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 244
HIS A 240
HIS A 109
HIS A  88
VAL A  87
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
None
 1.18A 5z0fA-1bt2A:
20.9
5z0fB-1bt2A:
0.0		 5z0fA-1bt2A:
13.04
5z0fB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.22A 5z0gA-1bt2A:
20.8
5z0gB-1bt2A:
undetectable		 5z0gA-1bt2A:
13.04
5z0gB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
ILE A 241
HIS A 244
HIS A  88
HIS A 109
 C2O  A 500 ( 3.2A)
None
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
 1.11A 5z0gA-1bt2A:
20.8
5z0gB-1bt2A:
undetectable		 5z0gA-1bt2A:
13.04
5z0gB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0G_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 244
HIS A 240
HIS A 109
HIS A  88
VAL A  87
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.2A)
None
 1.19A 5z0gA-1bt2A:
20.8
5z0gB-1bt2A:
undetectable		 5z0gA-1bt2A:
13.04
5z0gB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.25A 5z0hA-1bt2A:
20.9
5z0hB-1bt2A:
undetectable		 5z0hA-1bt2A:
13.04
5z0hB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0H_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
PRO A  19
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.22A 5z0hA-1bt2A:
20.9
5z0hB-1bt2A:
undetectable		 5z0hA-1bt2A:
13.04
5z0hB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.25A 5z0iA-1bt2A:
20.9
5z0iB-1bt2A:
undetectable		 5z0iA-1bt2A:
13.04
5z0iB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
PRO A  19
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.23A 5z0iA-1bt2A:
20.9
5z0iB-1bt2A:
undetectable		 5z0iA-1bt2A:
13.04
5z0iB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0I_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
ILE A 241
HIS A 244
HIS A  88
HIS A 109
 C2O  A 500 ( 3.2A)
None
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
 1.10A 5z0iA-1bt2A:
20.9
5z0iB-1bt2A:
undetectable		 5z0iA-1bt2A:
13.04
5z0iB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.22A 5z0jA-1bt2A:
20.9
5z0jB-1bt2A:
undetectable		 5z0jA-1bt2A:
13.04
5z0jB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0J_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
PRO A  19
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.19A 5z0jA-1bt2A:
20.9
5z0jB-1bt2A:
undetectable		 5z0jA-1bt2A:
13.04
5z0jB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.21A 5z0kA-1bt2A:
20.8
5z0kB-1bt2A:
undetectable		 5z0kA-1bt2A:
13.04
5z0kB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0K_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
PRO A  19
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.21A 5z0kA-1bt2A:
20.8
5z0kB-1bt2A:
undetectable		 5z0kA-1bt2A:
13.04
5z0kB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.25A 5z0lA-1bt2A:
20.8
5z0lB-1bt2A:
undetectable		 5z0lA-1bt2A:
13.04
5z0lB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
PRO A  19
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.23A 5z0lA-1bt2A:
20.8
5z0lB-1bt2A:
undetectable		 5z0lA-1bt2A:
13.04
5z0lB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0L_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
ILE A 241
HIS A 244
HIS A  88
HIS A 109
 C2O  A 500 ( 3.2A)
None
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
 1.18A 5z0lA-1bt2A:
20.8
5z0lB-1bt2A:
undetectable		 5z0lA-1bt2A:
13.04
5z0lB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0M_B_DAHB98_0
(MELC
TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 11 HIS A 240
HIS A 244
HIS A  88
HIS A 109
ASP A  17
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
None
 1.32A 5z0mA-1bt2A:
20.9
5z0mB-1bt2A:
undetectable		 5z0mA-1bt2A:
13.38
5z0mB-1bt2A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA607_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		3 / 3 HIS A 240
HIS A 244
HIS A 274
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
 0.24A 5zrdA-1bt2A:
3.3		 5zrdA-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB606_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 5 HIS A 240
HIS A 244
PHE A 270
HIS A 273
HIS A 274
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 4.8A)
None
C2O  A 500 ( 3.2A)
 0.35A 5zrdB-1bt2A:
undetectable		 5zrdB-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A  88
CYH A  92
HIS A 109
PHE A 270
 C2O  A 500 ( 3.2A)
C2O  A 500 (-3.5A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 4.8A)
 1.07A 5zrdB-1bt2A:
undetectable		 5zrdB-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A  88
HIS A 109
HIS A 118
PHE A 270
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 4.8A)
 0.31A 5zrdB-1bt2A:
undetectable		 5zrdB-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_B_CUB607_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A 240
HIS A 244
HIS A 274
PHE A 114
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 1.07A 5zrdB-1bt2A:
undetectable		 5zrdB-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC604_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 240
HIS A 244
HIS A 273
HIS A 274
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
C2O  A 500 ( 3.2A)
 0.29A 5zrdC-1bt2A:
3.2		 5zrdC-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A  88
CYH A  92
HIS A 109
PHE A 270
 C2O  A 500 ( 3.2A)
C2O  A 500 (-3.5A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 4.8A)
 1.08A 5zrdC-1bt2A:
3.2		 5zrdC-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A  88
HIS A 109
HIS A 118
PHE A 270
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 4.8A)
 0.23A 5zrdC-1bt2A:
3.2		 5zrdC-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_C_CUC605_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A 240
HIS A 244
HIS A 274
PHE A 114
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 1.11A 5zrdC-1bt2A:
3.2		 5zrdC-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A  88
CYH A  92
HIS A 109
PHE A 270
 C2O  A 500 ( 3.2A)
C2O  A 500 (-3.5A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 4.8A)
 1.07A 5zrdD-1bt2A:
4.5		 5zrdD-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A  88
HIS A 109
HIS A 118
PHE A 270
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 3.3A)
C2O  A 500 ( 4.8A)
 0.31A 5zrdD-1bt2A:
4.5		 5zrdD-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD606_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 5 HIS A 240
HIS A 244
HIS A 274
PHE A 114
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
 1.09A 5zrdD-1bt2A:
4.5		 5zrdD-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_D_CUD607_0
(TYROSINASE)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		4 / 4 HIS A 240
HIS A 244
HIS A 273
HIS A 274
 C2O  A 500 ( 3.2A)
C2O  A 500 ( 3.2A)
None
C2O  A 500 ( 3.2A)
 0.31A 5zrdD-1bt2A:
4.5		 5zrdD-1bt2A:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWO_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 9 TYR A 296
ASP A 295
ALA A 304
ILE A 320
GLY A 219
 None
 1.23A 6awoA-1bt2A:
0.0		 6awoA-1bt2A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWQ_A_SREA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1bt2 PROTEIN (CATECHOL
OXIDASE)
(Ipomoea
batatas) 		5 / 9 TYR A 296
ASP A 295
ALA A 304
ILE A 320
GLY A 219
 None
 1.22A 6awqA-1bt2A:
0.0		 6awqA-1bt2A:
18.92