SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bt4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		3 / 3 LEU A 221
PRO A 222
LEU A 225
 None
 0.47A 1hrkA-1bt4A:
undetectable		 1hrkA-1bt4A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG2_A_ADNA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		5 / 12 GLY A 203
GLY A  75
ILE A  73
GLY A 244
ALA A 195
 None
 1.09A 1jg2A-1bt4A:
undetectable		 1jg2A-1bt4A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KIJ_B_NOVB444_2
(DNA GYRASE SUBUNIT B)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		3 / 3 ASP A 212
PHE A  88
VAL A 209
 None
 0.79A 1kijB-1bt4A:
0.0		 1kijB-1bt4A:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		5 / 9 LEU A  15
VAL A 248
GLY A 200
ALA A 195
SER A 202
 None
 1.30A 1pxxB-1bt4A:
0.0		 1pxxB-1bt4A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S1X_A_NVPA999_1
(REVERSE
TRANSCRIPTASE)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		4 / 8 LEU A  61
VAL A 264
GLY A 263
LEU A 179
 None
 1.03A 1s1xA-1bt4A:
undetectable		 1s1xA-1bt4A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y0X_X_T44X500_1
(THYROID HORMONE
RECEPTOR BETA-1)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		5 / 12 ALA A 193
ARG A 181
LEU A 252
ILE A 255
PHE A  72
 None
 1.36A 1y0xX-1bt4A:
0.0		 1y0xX-1bt4A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		4 / 5 TYR A 339
SER A 337
THR A 153
ASN A 151
 None
None
PLP  A 363 (-3.3A)
None
 1.43A 1yvpA-1bt4A:
undetectable		 1yvpA-1bt4A:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BDM_A_TMIA503_1
(CYTOCHROME P450 2B4)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		4 / 8 GLN A  55
LEU A  59
VAL A 206
LEU A  71
 None
 0.97A 2bdmA-1bt4A:
0.0		 2bdmA-1bt4A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXP_A_P1ZA3001_1
(SERUM ALBUMIN)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		5 / 12 LEU A  58
LEU A  62
LEU A 261
ILE A 255
SER A 180
 None
 0.99A 2bxpA-1bt4A:
undetectable		 2bxpA-1bt4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		5 / 12 ALA A 107
ALA A 104
THR A 100
GLN A 138
GLN A 140
 None
 1.11A 2jjpA-1bt4A:
0.0		 2jjpA-1bt4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_2
(PHOSPHOLIPASE A2)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		5 / 9 VAL A 331
GLY A 327
LYS A 326
THR A 153
GLY A 156
 None
None
None
PLP  A 363 (-3.3A)
None
 1.24A 3bjwG-1bt4A:
0.0		 3bjwG-1bt4A:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA2_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		3 / 3 LYS A 326
LYS A 311
VAL A 314
 None
 1.10A 3brfA-1bt4A:
undetectable		 3brfA-1bt4A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		4 / 8 SER A 176
ASN A 151
THR A 301
GLY A 101
 PLP  A 363 ( 3.9A)
None
None
None
 0.81A 3dcjB-1bt4A:
undetectable		 3dcjB-1bt4A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EDL_B_TA1B601_1
(BETA TUBULIN)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		5 / 12 LEU A  58
SER A 150
PHE A 183
LEU A  62
GLY A 189
 None
 1.22A 3edlB-1bt4A:
undetectable		 3edlB-1bt4A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IZ0_B_TA1B820_1
(BETA TUBULIN, CHAIN
B FROM PDB 1JFF)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		5 / 12 LEU A  58
SER A 150
PHE A 183
LEU A  62
GLY A 189
 None
 1.22A 3iz0B-1bt4A:
undetectable		 3iz0B-1bt4A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECLA600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		4 / 8 LEU A  71
GLY A 194
ALA A  77
ILE A  84
 None
PLP  A 363 ( 4.6A)
PLP  A 363 (-3.5A)
None
 0.66A 3jusA-1bt4A:
0.0		 3jusA-1bt4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_A_ECNA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		4 / 8 LEU A  71
GLY A 194
ALA A  77
ILE A  84
 None
PLP  A 363 ( 4.6A)
PLP  A 363 (-3.5A)
None
 0.66A 3jusA-1bt4A:
0.0		 3jusA-1bt4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECLB600_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		4 / 8 LEU A  71
GLY A 194
ALA A  77
ILE A  84
 None
PLP  A 363 ( 4.6A)
PLP  A 363 (-3.5A)
None
 0.63A 3jusB-1bt4A:
0.0		 3jusB-1bt4A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		4 / 5 ASN A   7
ALA A  14
TYR A 339
ALA A  10
 None
 1.36A 3twpD-1bt4A:
0.8		 3twpD-1bt4A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		5 / 12 GLY A 288
GLY A 284
GLY A 283
ASP A 280
VAL A 292
 None
 1.08A 4b17A-1bt4A:
undetectable		 4b17A-1bt4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		4 / 8 GLN A 138
GLN A 140
LYS A 112
THR A 117
 None
 1.06A 4d1yA-1bt4A:
undetectable
4d1yB-1bt4A:
undetectable		 4d1yA-1bt4A:
17.55
4d1yB-1bt4A:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_B_LNLB701_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		4 / 7 VAL A 251
VAL A  19
LEU A  20
ASN A 268
 None
 1.00A 4e1gB-1bt4A:
0.0		 4e1gB-1bt4A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		5 / 12 ALA A 336
TYR A 286
LEU A 304
ARG A 361
GLY A 362
 None
 1.28A 4l9qA-1bt4A:
0.0		 4l9qA-1bt4A:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		4 / 8 ASN A 127
GLU A 124
GLU A 155
TYR A  97
 None
 1.14A 4mj8A-1bt4A:
undetectable
4mj8C-1bt4A:
0.0		 4mj8A-1bt4A:
20.49
4mj8C-1bt4A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA601_1
(SERUM ALBUMIN)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		5 / 11 PHE A 162
ARG A 181
THR A 100
LEU A 131
SER A 296
 None
 1.22A 4or0A-1bt4A:
undetectable		 4or0A-1bt4A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZY_A_SAMA603_0
(LEGIONELLA EFFECTOR
LEGAS4)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		5 / 12 LEU A 190
GLY A 189
ARG A 210
SER A 217
TYR A 192
 None
 1.37A 5czyA-1bt4A:
0.0		 5czyA-1bt4A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1bt4 PHOSPHOSERINE
AMINOTRANSFERASE
(Bacillus
circulans) 		4 / 7 GLN A 196
GLY A 194
VAL A 207
SER A  78
 PLP  A 363 (-3.2A)
PLP  A 363 ( 4.6A)
None
PLP  A 363 (-2.7A)
 1.05A 6hu9S-1bt4A:
0.0
6hu9q-1bt4A:
undetectable		 6hu9S-1bt4A:
13.64
6hu9q-1bt4A:
18.05