SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1btc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DZ9_A_CAMA503_0
(CYTOCHROME P450-CAM)		 1btc BETA-AMYLASE
(Glycine
max) 		4 / 8 LEU A  86
VAL A  50
THR A 417
ASP A  53
 None
 1.13A 1dz9A-1btcA:
undetectable		 1dz9A-1btcA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ISM_B_NCAB305_0
(BONE MARROW STROMAL
CELL ANTIGEN 1)		 1btc BETA-AMYLASE
(Glycine
max) 		4 / 7 HIS A 273
LEU A 135
ASP A 140
PHE A  92
 None
 1.07A 1ismB-1btcA:
1.2		 1ismB-1btcA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UYU_A_CAMA1416_0
(CYTOCHROME P450-CAM)		 1btc BETA-AMYLASE
(Glycine
max) 		4 / 8 LEU A  86
VAL A  50
THR A 417
ASP A  53
 None
 1.15A 1uyuA-1btcA:
undetectable		 1uyuA-1btcA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 1btc BETA-AMYLASE
(Glycine
max) 		3 / 3 LEU A 344
LEU A 396
MET A 441
 None
 0.76A 1ya3B-1btcA:
0.0		 1ya3B-1btcA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1btc BETA-AMYLASE
(Glycine
max) 		3 / 3 LYS A 467
ASP A 140
ASN A 272
 None
 0.94A 2bm9A-1btcA:
undetectable		 2bm9A-1btcA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CEO_A_T44A1395_1
(THYROXINE-BINDING
GLOBULIN)		 1btc BETA-AMYLASE
(Glycine
max) 		5 / 11 LEU A  84
LEU A  39
SER A 422
LEU A 421
LEU A  42
 None
 1.00A 2ceoA-1btcA:
0.0		 2ceoA-1btcA:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 1btc BETA-AMYLASE
(Glycine
max) 		10 / 12 ALA A 184
GLU A 186
ARG A 188
TYR A 192
GLN A 194
TRP A 198
SER A 297
GLY A 298
HIS A 300
MET A 346
 BME  A 502 ( 3.9A)
None
None
None
GLC  A 499 ( 4.0A)
None
None
BME  A 504 ( 4.3A)
GLC  A 499 ( 4.0A)
GLC  A 499 (-3.7A)
 0.67A 2xffA-1btcA:
61.8		 2xffA-1btcA:
62.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 1btc BETA-AMYLASE
(Glycine
max) 		10 / 12 ALA A 184
GLU A 186
ARG A 188
TYR A 192
TRP A 198
PHE A 200
SER A 297
GLY A 298
HIS A 300
MET A 346
 BME  A 502 ( 3.9A)
None
None
None
None
GLC  A 499 ( 3.6A)
None
BME  A 504 ( 4.3A)
GLC  A 499 ( 4.0A)
GLC  A 499 (-3.7A)
 0.50A 2xffA-1btcA:
61.8		 2xffA-1btcA:
62.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2XFF_A_QPSA600_1
(BETA-AMYLASE)		 1btc BETA-AMYLASE
(Glycine
max) 		6 / 12 TYR A 192
GLN A 194
TRP A 198
SER A 297
GLY A 298
THR A 342
 None
GLC  A 499 ( 4.0A)
None
None
BME  A 504 ( 4.3A)
None
 1.10A 2xffA-1btcA:
61.8		 2xffA-1btcA:
62.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN7_A_T44A1355_1
(THYROXINE-BINDING
GLOBULIN)		 1btc BETA-AMYLASE
(Glycine
max) 		5 / 10 LEU A  84
LEU A  39
SER A 422
LEU A 421
LEU A  42
 None
 1.02A 2xn7A-1btcA:
0.0
2xn7B-1btcA:
0.0		 2xn7A-1btcA:
22.35
2xn7B-1btcA:
6.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 1btc BETA-AMYLASE
(Glycine
max) 		4 / 7 VAL A 363
ASP A 348
ILE A 394
ASN A 397
 BME  A 504 (-4.5A)
None
None
None
 0.97A 3avpA-1btcA:
0.0		 3avpA-1btcA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_E_RTLE177_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1btc BETA-AMYLASE
(Glycine
max) 		5 / 11 LEU A  84
ALA A  45
VAL A  79
LEU A  18
HIS A 442
 None
 1.13A 3bszE-1btcA:
0.0		 3bszE-1btcA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ETE_A_H3PA552_1
(GLUTAMATE
DEHYDROGENASE)		 1btc BETA-AMYLASE
(Glycine
max) 		4 / 6 ILE A 121
TYR A 134
ILE A 153
HIS A 146
 None
 1.06A 3eteA-1btcA:
undetectable
3eteE-1btcA:
undetectable		 3eteA-1btcA:
21.58
3eteE-1btcA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_A_BEZA302_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1btc BETA-AMYLASE
(Glycine
max) 		4 / 6 PRO A 183
LEU A 270
ALA A 314
PRO A 190
 None
 1.06A 3gv1A-1btcA:
0.0
3gv1C-1btcA:
0.0		 3gv1A-1btcA:
13.09
3gv1C-1btcA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GV1_B_BEZB301_0
(DISULFIDE
INTERCHANGE PROTEIN)		 1btc BETA-AMYLASE
(Glycine
max) 		4 / 6 LEU A 270
ALA A 314
PRO A 190
PRO A 183
 None
 1.10A 3gv1A-1btcA:
0.0
3gv1B-1btcA:
undetectable		 3gv1A-1btcA:
13.09
3gv1B-1btcA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 1btc BETA-AMYLASE
(Glycine
max) 		5 / 12 LEU A 474
LEU A 473
ALA A 329
ASP A 323
THR A 480
 None
 1.31A 3gwuA-1btcA:
0.0		 3gwuA-1btcA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_C_ACTC1113_0
(BLR5658 PROTEIN)		 1btc BETA-AMYLASE
(Glycine
max) 		4 / 4 ASN A 340
ALA A 378
GLY A 379
THR A 417
 None
 1.29A 4bboC-1btcA:
0.0		 4bboC-1btcA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0U_F_ASWF101_1
(DNA TOPOISOMERASE
2-BETA)		 1btc BETA-AMYLASE
(Glycine
max) 		4 / 6 GLY A 298
ALA A 184
GLU A 186
GLN A 351
 BME  A 504 ( 4.3A)
BME  A 502 ( 3.9A)
None
GLC  A 499 ( 3.6A)
 1.09A 4g0uA-1btcA:
undetectable		 4g0uA-1btcA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_B_MRVB1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 1btc BETA-AMYLASE
(Glycine
max) 		4 / 5 TYR A 325
THR A 136
LEU A 213
THR A 264
 None
 1.28A 4mbsB-1btcA:
0.0		 4mbsB-1btcA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1btc BETA-AMYLASE
(Glycine
max) 		4 / 6 LEU A 339
ILE A 338
LYS A 295
GLU A 380
 None
 0.79A 4w5nA-1btcA:
2.0		 4w5nA-1btcA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 1btc BETA-AMYLASE
(Glycine
max) 		4 / 6 ILE A 338
PHE A 414
ARG A 376
ILE A 458
 None
 1.10A 4zzcA-1btcA:
0.0
4zzcB-1btcA:
0.0		 4zzcA-1btcA:
22.47
4zzcB-1btcA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 1btc BETA-AMYLASE
(Glycine
max) 		4 / 6 ILE A 338
PHE A 414
ARG A 376
ILE A 458
 None
 1.06A 4zzcB-1btcA:
0.0
4zzcC-1btcA:
0.0		 4zzcB-1btcA:
22.47
4zzcC-1btcA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 1btc BETA-AMYLASE
(Glycine
max) 		3 / 3 THR A 253
THR A 256
PHE A 261
 None
 0.60A 5cxvA-1btcA:
undetectable		 5cxvA-1btcA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1btc BETA-AMYLASE
(Glycine
max) 		3 / 3 ARG A 188
PRO A 183
ASN A 131
 None
 1.00A 5jwaA-1btcA:
1.8
5jwaH-1btcA:
1.9		 5jwaA-1btcA:
22.68
5jwaH-1btcA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 1btc BETA-AMYLASE
(Glycine
max) 		4 / 6 GLU A 306
PHE A 247
THR A 253
TYR A 254
 None
 1.39A 5lrbA-1btcA:
2.3		 5lrbA-1btcA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 1btc BETA-AMYLASE
(Glycine
max) 		4 / 5 ILE A 299
PHE A 200
SER A 357
ALA A 310
 None
GLC  A 499 ( 3.6A)
None
None
 1.21A 5msdA-1btcA:
2.6		 5msdA-1btcA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GTQ_B_ACTB207_0
(DUF1778
DOMAIN-CONTAINING
PROTEIN
N-ACETYLTRANSFERASE)		 1btc BETA-AMYLASE
(Glycine
max) 		4 / 6 LEU A 474
THR A 477
GLY A 324
ARG A 322
 None
 1.16A 6gtqB-1btcA:
0.0
6gtqD-1btcA:
undetectable		 6gtqB-1btcA:
16.33
6gtqD-1btcA:
7.01