SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1btn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 1btn BETA-SPECTRIN
(Mus
musculus) 		4 / 5 ASN A  15
ASN A  84
HIS A   9
ALA A  18
 None
 0.98A 3frqA-1btnA:
undetectable		 3frqA-1btnA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 1btn BETA-SPECTRIN
(Mus
musculus) 		4 / 7 ASN A  15
ASN A  84
HIS A   9
ALA A  18
 None
 1.00A 3frqB-1btnA:
undetectable		 3frqB-1btnA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1btn BETA-SPECTRIN
(Mus
musculus) 		3 / 3 ASP A  93
LYS A  91
LEU A   5
 None
 0.97A 4ptjA-1btnA:
undetectable		 4ptjA-1btnA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNW_A_RTZA602_1
(CYTOCHROME P450 2D6)		 1btn BETA-SPECTRIN
(Mus
musculus) 		5 / 12 PHE A  88
LEU A  87
GLY A  83
LEU A  80
VAL A  56
 None
 1.18A 4wnwA-1btnA:
undetectable		 4wnwA-1btnA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_A_RIOA600_0
(BIFUNCTIONAL AAC/APH)		 1btn BETA-SPECTRIN
(Mus
musculus) 		5 / 11 ASP A  82
SER A  20
GLU A  12
VAL A  54
GLU A  53
 None
 1.32A 5iqdA-1btnA:
0.1		 5iqdA-1btnA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_B_RIOB600_0
(BIFUNCTIONAL AAC/APH)		 1btn BETA-SPECTRIN
(Mus
musculus) 		5 / 11 ASP A  82
SER A  20
GLU A  12
VAL A  54
GLU A  53
 None
 1.32A 5iqdB-1btnA:
undetectable		 5iqdB-1btnA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQD_C_RIOC600_0
(BIFUNCTIONAL AAC/APH)		 1btn BETA-SPECTRIN
(Mus
musculus) 		5 / 12 ASP A  82
SER A  20
GLU A  12
VAL A  54
GLU A  53
 None
 1.29A 5iqdC-1btnA:
0.0		 5iqdC-1btnA:
15.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGJ_A_X6XA402_1
(PREDICTED
ACETYLTRANSFERASE)		 1btn BETA-SPECTRIN
(Mus
musculus) 		4 / 5 ARG A  79
TRP A  11
GLU A  85
ASP A  68
 None
 1.24A 5kgjA-1btnA:
undetectable		 5kgjA-1btnA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_0
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1btn BETA-SPECTRIN
(Mus
musculus) 		4 / 8 MET A  96
ILE A 100
VAL A  26
LYS A  39
 None
 1.15A 6fbvC-1btnA:
0.0		 6fbvC-1btnA:
6.20