SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bu8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		5 / 10 LEU A 281
ASP A 200
VAL A 325
GLY A 316
PRO A 300
 None
 1.23A 1d4sA-1bu8A:
undetectable		 1d4sA-1bu8A:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MUI_B_AB1B100_1
(PROTEASE)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		5 / 10 ALA A 161
VAL A 124
GLY A 150
ILE A 149
ILE A 128
 None
 0.94A 1muiA-1bu8A:
undetectable		 1muiA-1bu8A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UDT_A_VIAA1000_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		5 / 12 ALA A 129
ILE A 128
VAL A 169
ALA A 196
PHE A  72
 None
 1.22A 1udtA-1bu8A:
undetectable		 1udtA-1bu8A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		5 / 11 HIS A   7
ALA A 129
ILE A 128
ILE A  59
PHE A  38
 None
 1.22A 2h42A-1bu8A:
0.0		 2h42A-1bu8A:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IVU_A_ZD6A3015_1
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET
PRECURSOR)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		3 / 3 ALA A 155
GLY A 216
SER A 266
 None
 0.52A 2ivuA-1bu8A:
0.0		 2ivuA-1bu8A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JB7_B_ACTB1169_0
(HYPOTHETICAL PROTEIN
PAE2307)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		3 / 3 ARG A 163
ARG A 164
ARG A 122
 None
 1.16A 2jb7A-1bu8A:
0.3
2jb7B-1bu8A:
0.0
2jb7C-1bu8A:
0.4		 2jb7A-1bu8A:
16.23
2jb7B-1bu8A:
16.23
2jb7C-1bu8A:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M2O_B_DHIB24_0
(INSULIN B CHAIN)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		4 / 6 ARG A 164
GLY A 125
PRO A  31
THR A  36
 None
 1.12A 2m2oB-1bu8A:
undetectable		 2m2oB-1bu8A:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		5 / 10 SER A  62
ILE A  52
ILE A 102
LEU A 131
VAL A 146
 None
 1.23A 2nnhB-1bu8A:
0.0		 2nnhB-1bu8A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHC_B_AB1B9001_1
(PROTEASE RETROPEPSIN)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		5 / 11 ALA A 161
VAL A 124
GLY A 150
ILE A 149
ILE A 128
 None
 1.00A 2qhcA-1bu8A:
undetectable		 2qhcA-1bu8A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		3 / 3 LEU A   8
VAL A 157
ARG A 164
 None
 0.60A 3b0wB-1bu8A:
0.0		 3b0wB-1bu8A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		5 / 12 GLY A 174
HIS A 151
LEU A 224
MET A 307
LEU A 327
 None
 1.12A 3bxoA-1bu8A:
undetectable		 3bxoA-1bu8A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_B_SHHB301_1
(HISTONE DEACETYLASE
7A)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		4 / 8 ASP A 205
HIS A 263
PHE A  77
GLY A 214
 None
 0.90A 3c0zB-1bu8A:
2.1		 3c0zB-1bu8A:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		5 / 8 ALA A 161
VAL A 124
GLY A 150
ILE A 149
ILE A 128
 None
 1.08A 3ekpA-1bu8A:
0.0		 3ekpA-1bu8A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKP_B_478B200_1
(PROTEASE)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		5 / 8 GLY A 162
ALA A 161
VAL A 124
GLY A 150
ILE A 128
 None
 1.16A 3ekpA-1bu8A:
0.0		 3ekpA-1bu8A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKT_B_017B200_2
(PROTEASE)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		5 / 9 ALA A 161
VAL A 124
GLY A 150
ILE A 149
ILE A 128
 None
 1.01A 3ektB-1bu8A:
undetectable		 3ektB-1bu8A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		5 / 9 ALA A 161
VAL A 124
GLY A 150
ILE A 149
ILE A 128
 None
 1.00A 3ekvB-1bu8A:
undetectable		 3ekvB-1bu8A:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N62_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		3 / 3 GLY A 125
TRP A 106
VAL A  74
 None
 0.52A 3n62B-1bu8A:
undetectable		 3n62B-1bu8A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N65_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		3 / 3 GLY A 125
TRP A 106
VAL A  74
 None
 0.52A 3n65B-1bu8A:
0.0		 3n65B-1bu8A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N66_B_ACTB860_0
(NITRIC OXIDE
SYNTHASE)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		3 / 3 GLY A 125
TRP A 106
VAL A  74
 None
 0.52A 3n66B-1bu8A:
0.4		 3n66B-1bu8A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		5 / 10 ALA A 161
VAL A 124
GLY A 150
ILE A 149
ILE A 128
 None
 1.01A 3nujA-1bu8A:
undetectable		 3nujA-1bu8A:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P6H_A_IBPA133_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		4 / 7 PHE A 258
ASP A 176
ILE A 209
VAL A 246
 None
 1.02A 3p6hA-1bu8A:
undetectable		 3p6hA-1bu8A:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA1_1
(CYTOCHROME P450 2D6)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		5 / 12 LEU A  86
GLY A 154
LEU A 153
SER A 110
PHE A 215
 None
 1.32A 3tbgA-1bu8A:
0.0		 3tbgA-1bu8A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		4 / 8 PHE A 215
GLY A 214
GLY A 254
ASN A 249
 None
 0.93A 3v3nB-1bu8A:
undetectable		 3v3nB-1bu8A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		4 / 8 PHE A 215
GLY A 214
GLY A 254
ASN A 249
 None
 0.93A 3v3nC-1bu8A:
undetectable		 3v3nC-1bu8A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		5 / 10 ALA A 161
VAL A 124
GLY A 150
ILE A 149
ILE A 128
 None
 1.02A 4dqcA-1bu8A:
undetectable		 4dqcA-1bu8A:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		4 / 5 PHE A  77
ILE A 251
GLY A 250
THR A 255
 None
 0.84A 4ejjC-1bu8A:
undetectable		 4ejjC-1bu8A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_D_FOLD301_1
(FOLATE RECEPTOR
ALPHA)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		3 / 3 HIS A 151
TRP A 106
SER A 266
 None
 1.13A 4lrhD-1bu8A:
0.0		 4lrhD-1bu8A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		4 / 7 VAL A 124
ILE A 128
PHE A  72
VAL A  74
 None
 0.67A 5bmvC-1bu8A:
undetectable		 5bmvC-1bu8A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_2
(TUBULIN ALPHA-1B
CHAIN)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		4 / 7 VAL A 124
ILE A 128
PHE A  72
VAL A 104
 None
 0.77A 5bmvC-1bu8A:
undetectable		 5bmvC-1bu8A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J2T_C_VLBC503_2
(TUBULIN ALPHA-1B
CHAIN)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		6 / 12 LEU A 153
VAL A 124
ILE A 128
ALA A 129
PHE A  72
VAL A  74
 None
 0.93A 5j2tC-1bu8A:
4.5		 5j2tC-1bu8A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_ACTB804_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1bu8 PROTEIN (PANCREATIC
LIPASE RELATED
PROTEIN 2)
(Rattus
norvegicus) 		3 / 3 GLY A 125
TRP A 106
VAL A  74
 None
 0.51A 5vuoB-1bu8A:
0.3		 5vuoB-1bu8A:
22.52