SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bvs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1bvs PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)
(Mycobacterium
leprae) 		3 / 3 THR A  37
LEU A  38
LEU A  10
 None
 0.58A 1mz9C-1bvsA:
undetectable		 1mz9C-1bvsA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O01_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1bvs PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)
(Mycobacterium
leprae) 		4 / 8 PHE A  62
SER A  63
ALA A  90
LEU A  89
 None
 1.02A 2o01A-1bvsA:
0.0		 2o01A-1bvsA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PKK_A_2FAA501_2
(ADENOSINE KINASE)		 1bvs PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)
(Mycobacterium
leprae) 		4 / 4 ALA A  73
VAL A  80
PHE A  71
THR A  88
 None
 1.42A 2pkkA-1bvsA:
undetectable		 2pkkA-1bvsA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 1bvs PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)
(Mycobacterium
leprae) 		3 / 3 VAL A  28
PHE A  62
ARG A  68
 None
 0.92A 4xr4B-1bvsA:
undetectable		 4xr4B-1bvsA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1bvs PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)
(Mycobacterium
leprae) 		3 / 3 LYS A 130
LEU A  97
ILE A 123
 None
 0.67A 5kc4A-1bvsA:
undetectable		 5kc4A-1bvsA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1bvs PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)
(Mycobacterium
leprae) 		6 / 11 LEU A 192
GLU A 169
GLY A 152
LEU A 196
THR A 172
ALA A 195
 None
 1.13A 5o96A-1bvsA:
undetectable
5o96B-1bvsA:
undetectable		 5o96A-1bvsA:
23.11
5o96B-1bvsA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1bvs PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)
(Mycobacterium
leprae) 		5 / 11 LEU A 192
LEU A 196
THR A 172
ALA A 195
GLN A 167
 None
 1.10A 5o96A-1bvsA:
undetectable
5o96B-1bvsA:
undetectable		 5o96A-1bvsA:
23.11
5o96B-1bvsA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1bvs PROTEIN (HOLLIDAY
JUNCTION DNA
HELICASE RUVA)
(Mycobacterium
leprae) 		3 / 3 ASN A  67
VAL A 112
HIS A  92
 None
 0.82A 6a5yD-1bvsA:
undetectable		 6a5yD-1bvsA:
17.33