SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bw0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7R_A_NCTA440_1
(CYTOCHROME P450-CAM)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		4 / 7 PHE A 214
VAL A 144
ASP A 216
ILE A 182
 None
None
LLP  A 253 ( 2.8A)
None
 0.99A 1p7rA-1bw0A:
0.0		 1p7rA-1bw0A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_C_NCAC439_0
(ADP-RIBOSYL CYCLASE)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		3 / 3 TRP A  87
PHE A  92
TRP A  88
 None
 1.23A 1r15C-1bw0A:
1.5		 1r15C-1bw0A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_F_NCAF469_0
(ADP-RIBOSYL CYCLASE)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		3 / 3 TRP A  87
PHE A  92
TRP A  88
 None
 1.22A 1r15F-1bw0A:
1.5		 1r15F-1bw0A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_G_NCAG479_0
(ADP-RIBOSYL CYCLASE)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		3 / 3 TRP A  87
PHE A  92
TRP A  88
 None
 1.21A 1r15G-1bw0A:
1.1		 1r15G-1bw0A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R15_H_NCAH489_0
(ADP-RIBOSYL CYCLASE)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		3 / 3 TRP A  87
PHE A  92
TRP A  88
 None
 1.21A 1r15H-1bw0A:
1.1		 1r15H-1bw0A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		3 / 3 GLU A 240
GLU A 200
LEU A 213
 None
 0.67A 1v8bB-1bw0A:
2.7		 1v8bB-1bw0A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_G_BEZG3385_0
(CES1 PROTEIN)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		3 / 3 SER A 348
VAL A 376
LEU A 390
 None
 0.74A 1yajG-1bw0A:
2.6		 1yajG-1bw0A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		5 / 12 LEU A 262
GLU A  79
GLY A 300
SER A  77
ALA A  54
 None
 1.10A 2bm9A-1bw0A:
3.7		 2bm9A-1bw0A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_B_SAMB500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		5 / 12 ILE A 218
ALA A 120
GLY A 113
VAL A 144
PHE A 277
 LLP  A 253 ( 3.9A)
None
LLP  A 253 ( 3.6A)
None
None
 1.17A 2okcB-1bw0A:
3.1		 2okcB-1bw0A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		4 / 6 PHE A 233
PHE A  92
GLY A 249
GLY A 250
 None
 1.01A 2qr2A-1bw0A:
3.2
2qr2B-1bw0A:
3.2		 2qr2A-1bw0A:
20.38
2qr2B-1bw0A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		4 / 5 GLY A 249
GLY A 250
PHE A 233
PHE A  92
 None
 1.03A 2qr2A-1bw0A:
3.2
2qr2B-1bw0A:
3.2		 2qr2A-1bw0A:
20.38
2qr2B-1bw0A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UZ2_A_ACTA1123_0
(XENAVIDIN)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		4 / 7 ASN A  48
LEU A  49
THR A  44
VAL A 256
 None
None
None
LLP  A 253 ( 4.1A)
 1.17A 2uz2A-1bw0A:
undetectable		 2uz2A-1bw0A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_F_DVAF8_0
(VAL-GRAMICIDIN A)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		3 / 3 TRP A  88
VAL A 103
TRP A 264
 None
 1.33A 2y5mE-1bw0A:
undetectable
2y5mF-1bw0A:
undetectable		 2y5mE-1bw0A:
5.86
2y5mF-1bw0A:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_C_DVAC10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		3 / 3 GLY A 112
GLY A 250
GLY A 263
 LLP  A 253 ( 4.6A)
None
None
 0.39A 3bogC-1bw0A:
0.0		 3bogC-1bw0A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DVAD10_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		3 / 3 GLY A 112
GLY A 250
GLY A 263
 LLP  A 253 ( 4.6A)
None
None
 0.34A 3bogD-1bw0A:
0.0		 3bogD-1bw0A:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MB5_A_SAMA301_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		4 / 4 GLY A 226
GLU A 319
ASP A 312
ASP A 228
 None
 1.16A 3mb5A-1bw0A:
4.6		 3mb5A-1bw0A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		3 / 3 GLN A 411
GLU A 331
LYS A 407
 None
 1.19A 3su9A-1bw0A:
0.0		 3su9A-1bw0A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		5 / 12 LEU A 262
GLY A 116
GLY A 113
LEU A 265
VAL A 246
 None
None
LLP  A 253 ( 3.6A)
None
None
 1.02A 4gc9A-1bw0A:
undetectable		 4gc9A-1bw0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		5 / 11 ILE A 406
GLN A 375
LEU A 368
HIS A 328
LEU A 325
 None
 1.06A 4nqaA-1bw0A:
undetectable		 4nqaA-1bw0A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_H_9CRH501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		5 / 12 ILE A 406
GLN A 375
LEU A 368
HIS A 328
LEU A 325
 None
 1.03A 4nqaH-1bw0A:
undetectable		 4nqaH-1bw0A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		3 / 3 MET A 222
MET A 323
TYR A 345
 LLP  A 253 ( 3.7A)
None
None
 1.34A 4p6xI-1bw0A:
0.0		 4p6xI-1bw0A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		4 / 7 GLU A 371
PHE A 364
TYR A 355
HIS A 413
 None
 1.48A 4uciB-1bw0A:
2.0		 4uciB-1bw0A:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		5 / 12 GLY A 285
MET A 286
GLY A 300
LEU A 262
THR A  74
 None
 1.31A 4ze1A-1bw0A:
0.0		 4ze1A-1bw0A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0O_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		5 / 12 GLY A 249
VAL A  84
ALA A 220
PHE A  92
VAL A 236
 None
 1.03A 5n0oB-1bw0A:
2.3		 5n0oB-1bw0A:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		5 / 12 GLY A 249
VAL A  84
ALA A 220
PHE A  92
VAL A 236
 None
 1.00A 5n0tB-1bw0A:
1.9		 5n0tB-1bw0A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		4 / 7 PHE A 214
ASP A 216
GLY A 116
GLY A 113
 None
LLP  A 253 ( 2.8A)
None
LLP  A 253 ( 3.6A)
 0.88A 5n9xA-1bw0A:
3.4		 5n9xA-1bw0A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYI_A_NIZA805_1
(CATALASE-PEROXIDASE)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		4 / 5 ARG A 261
TRP A 260
ALA A 252
PRO A  43
 LLP  A 253 ( 2.9A)
None
LLP  A 253 ( 3.1A)
None
 1.35A 5syiA-1bw0A:
undetectable		 5syiA-1bw0A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		5 / 10 ILE A 117
LEU A 281
LEU A 266
ASP A 216
PHE A 214
 None
None
None
LLP  A 253 ( 2.8A)
None
 1.33A 5tixB-1bw0A:
1.2		 5tixB-1bw0A:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		5 / 12 PRO A 340
GLY A 342
SER A 348
ALA A 384
PRO A 159
 None
 1.29A 5zvgA-1bw0A:
undetectable		 5zvgA-1bw0A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_0
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		5 / 12 PRO A 340
GLY A 342
SER A 348
ALA A 384
PRO A 159
 None
 1.30A 5zvgB-1bw0A:
undetectable		 5zvgB-1bw0A:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		4 / 6 ASP A  24
LEU A 377
SER A  39
PHE A 365
 None
 1.09A 6ekuA-1bw0A:
0.0		 6ekuA-1bw0A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 1bw0 PROTEIN (TYROSINE
AMINOTRANSFERASE)
(Trypanosoma
cruzi) 		3 / 3 ILE A 381
THR A 380
PRO A  18
 None
 0.63A 6ncsA-1bw0A:
2.4		 6ncsA-1bw0A:
22.86