SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bxd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1874_0
(FPRA)		 1bxd PROTEIN (OSMOLARITY
SENSOR PROTEIN
(ENVZ))
(Escherichia
coli) 		4 / 5 TRP A 435
ALA A 367
PHE A 369
SER A 360
 None
 1.46A 1lqtB-1bxdA:
0.9		 1lqtB-1bxdA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1431_0
(FPRA)		 1bxd PROTEIN (OSMOLARITY
SENSOR PROTEIN
(ENVZ))
(Escherichia
coli) 		4 / 5 TRP A 435
ALA A 367
PHE A 369
SER A 360
 None
 1.45A 1lquB-1bxdA:
0.1		 1lquB-1bxdA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PYY_A_STIA3_2
(V-ABL ABELSON MURINE
LEUKEMIA VIRAL
ONCOGENE HOMOLOG 1
ISOFORM B VARIANT)		 1bxd PROTEIN (OSMOLARITY
SENSOR PROTEIN
(ENVZ))
(Escherichia
coli) 		4 / 6 VAL A 346
VAL A 371
ILE A 319
ARG A 339
 None
 1.02A 3pyyA-1bxdA:
undetectable		 3pyyA-1bxdA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1bxd PROTEIN (OSMOLARITY
SENSOR PROTEIN
(ENVZ))
(Escherichia
coli) 		4 / 7 ARG A 366
SER A 336
VAL A 330
MET A 296
 None
 1.30A 4klaA-1bxdA:
0.0		 4klaA-1bxdA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1bxd PROTEIN (OSMOLARITY
SENSOR PROTEIN
(ENVZ))
(Escherichia
coli) 		4 / 6 ARG A 383
PRO A 380
THR A 424
ILE A 378
 None
None
None
ANP  A 451 (-3.2A)
 1.21A 5ih0A-1bxdA:
undetectable		 5ih0A-1bxdA:
19.74