SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bxk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J3J_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		5 / 10 ILE A   4
ALA A 240
ILE A  13
ILE A   6
THR A 241
 None
None
NAD  A 380 (-3.6A)
None
None
 1.28A 1j3jA-1bxkA:
0.9		 1j3jA-1bxkA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_A_ACTA1872_0
(FPRA)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		4 / 5 SER A 163
ASN A 101
ALA A  83
GLU A  84
 None
None
NAD  A 380 (-3.6A)
None
 1.39A 1lqtA-1bxkA:
6.7
1lqtB-1bxkA:
6.0		 1lqtA-1bxkA:
23.60
1lqtB-1bxkA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_A_ACTA1429_0
(FPRA)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		4 / 5 SER A 163
ASN A 101
ALA A  83
GLU A  84
 None
None
NAD  A 380 (-3.6A)
None
 1.37A 1lquA-1bxkA:
6.5
1lquB-1bxkA:
5.9		 1lquA-1bxkA:
23.60
1lquB-1bxkA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		3 / 3 LEU A 203
PRO A 202
LEU A 206
 None
 0.55A 2po5B-1bxkA:
2.4		 2po5B-1bxkA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		3 / 3 LEU A 203
PRO A 202
LEU A 206
 None
 0.58A 2po7B-1bxkA:
3.1		 2po7B-1bxkA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		4 / 8 TYR A 154
ASP A 168
SER A 133
TYR A 160
 None
 1.29A 2v0gA-1bxkA:
1.5		 2v0gA-1bxkA:
18.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_2
(PROTEASE)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		5 / 10 ARG A  52
GLY A  11
GLY A  14
LEU A  17
VAL A  47
 None
NAD  A 380 (-3.3A)
None
None
None
 0.95A 3em4V-1bxkA:
undetectable		 3em4V-1bxkA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NNE_G_ACTG601_0
(CHOLINE OXIDASE)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		4 / 6 ALA A  16
ILE A  13
HIS A 232
ASN A 190
 None
NAD  A 380 (-3.6A)
None
NAD  A 380 (-4.5A)
 1.20A 3nneG-1bxkA:
1.9		 3nneG-1bxkA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		3 / 3 HIS A 130
SER A 167
ASN A 186
 None
 0.75A 3s8pB-1bxkA:
undetectable		 3s8pB-1bxkA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_A_9PLA501_1
(CYTOCHROME P450 2A6)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		5 / 10 PHE A 129
PHE A 127
ALA A 111
THR A 107
ILE A  60
 None
None
None
None
NAD  A 380 (-3.9A)
 1.21A 3t3qA-1bxkA:
undetectable		 3t3qA-1bxkA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_B_9PLB501_1
(CYTOCHROME P450 2A6)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		5 / 10 PHE A 129
PHE A 127
ALA A 111
THR A 107
ILE A  60
 None
None
None
None
NAD  A 380 (-3.9A)
 1.24A 3t3qB-1bxkA:
0.0		 3t3qB-1bxkA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_C_9PLC501_1
(CYTOCHROME P450 2A6)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		5 / 10 PHE A 129
PHE A 127
ALA A 111
THR A 107
ILE A  60
 None
None
None
None
NAD  A 380 (-3.9A)
 1.23A 3t3qC-1bxkA:
0.0		 3t3qC-1bxkA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Q_D_9PLD501_1
(CYTOCHROME P450 2A6)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		5 / 10 PHE A 129
PHE A 127
ALA A 111
THR A 107
ILE A  60
 None
None
None
None
NAD  A 380 (-3.9A)
 1.22A 3t3qD-1bxkA:
0.0		 3t3qD-1bxkA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U52_A_CUA515_0
(PHENOL HYDROXYLASE
COMPONENT PHL
PHENOL HYDROXYLASE
COMPONENT PHN)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		3 / 3 HIS A  80
HIS A 131
ILE A 132
 None
None
NAD  A 380 (-4.8A)
 0.83A 3u52A-1bxkA:
0.0
3u52C-1bxkA:
undetectable		 3u52A-1bxkA:
20.97
3u52C-1bxkA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		5 / 12 SER A 322
GLY A 253
GLY A 323
ASP A 231
VAL A 315
 None
 0.88A 4b17A-1bxkA:
5.9		 4b17A-1bxkA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		4 / 5 LYS A 277
PRO A 278
GLU A 271
TYR A 284
 None
 1.33A 4w5tA-1bxkA:
2.3		 4w5tA-1bxkA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		4 / 6 LYS A 277
PRO A 278
GLU A 271
TYR A 284
 None
 1.37A 4z4cA-1bxkA:
3.1		 4z4cA-1bxkA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		4 / 6 LYS A 277
PRO A 278
LEU A 270
GLU A 271
 None
 1.05A 4z4cA-1bxkA:
3.1		 4z4cA-1bxkA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		4 / 7 LYS A 277
PRO A 278
LEU A 270
GLU A 271
 None
 1.04A 4z4fA-1bxkA:
2.3		 4z4fA-1bxkA:
16.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		5 / 12 LEU A 108
ALA A 112
LEU A   5
HIS A 131
LEU A 180
 None
 1.09A 4zn7A-1bxkA:
0.0		 4zn7A-1bxkA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		3 / 3 HIS A 130
SER A 167
ASN A 186
 None
 0.71A 5cprB-1bxkA:
0.0		 5cprB-1bxkA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_A_SALA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		4 / 8 LEU A 287
TYR A 284
GLY A 211
ALA A 210
 None
 0.77A 5f1aA-1bxkA:
undetectable		 5f1aA-1bxkA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F1A_B_SALB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		4 / 7 LEU A 287
TYR A 284
GLY A 211
ALA A 210
 None
 0.74A 5f1aB-1bxkA:
undetectable		 5f1aB-1bxkA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		5 / 12 ALA A 240
GLU A 247
LEU A 312
ILE A 308
CYH A 187
 None
None
None
None
NAD  A 380 (-3.3A)
 1.23A 5vlmA-1bxkA:
undetectable		 5vlmA-1bxkA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A5Y_D_9CRD501_0
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		5 / 12 ALA A 111
ALA A 112
LEU A  66
ALA A  67
ILE A   6
 None
 0.90A 6a5yD-1bxkA:
undetectable		 6a5yD-1bxkA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0L_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		5 / 12 VAL A  32
ASP A  33
THR A 185
GLY A  14
LEU A  17
 None
NAD  A 380 (-2.7A)
None
None
None
 1.09A 6b0lB-1bxkA:
7.4		 6b0lB-1bxkA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_1
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)
(Escherichia
coli) 		4 / 5 GLN A 342
GLU A 198
ASN A  40
TYR A 331
 None
 1.33A 6iftA-1bxkA:
4.9		 6iftA-1bxkA:
22.34