SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bxt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T46_A_STIA3_2
(HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG)		 1bxt PROTEIN
(STREPTOCOCCAL
SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 7 VAL A 229
TYR A 110
ARG A 167
CYH A 158
 None
 1.24A 1t46A-1bxtA:
undetectable		 1t46A-1bxtA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1bxt PROTEIN
(STREPTOCOCCAL
SUPERANTIGEN)
(Streptococcus
pyogenes) 		5 / 12 THR A 219
THR A 152
THR A 114
ILE A 144
ILE A 128
 None
 1.32A 3gwxA-1bxtA:
0.0		 3gwxA-1bxtA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_A_IMNA201_1
(TRANSTHYRETIN)		 1bxt PROTEIN
(STREPTOCOCCAL
SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 7 LEU A 211
THR A 107
THR A  66
VAL A  64
 None
 0.83A 4ik7A-1bxtA:
0.3		 4ik7A-1bxtA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IK7_B_IMNB201_1
(TRANSTHYRETIN)		 1bxt PROTEIN
(STREPTOCOCCAL
SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 8 LEU A 211
THR A 107
THR A  66
VAL A  64
 None
 0.82A 4ik7B-1bxtA:
0.1		 4ik7B-1bxtA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IWU_A_ACTA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1bxt PROTEIN
(STREPTOCOCCAL
SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 6 PHE A 142
VAL A 130
ILE A 183
ASP A 157
 None
 1.30A 5iwuA-1bxtA:
undetectable		 5iwuA-1bxtA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODI_A_ACTA701_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1bxt PROTEIN
(STREPTOCOCCAL
SUPERANTIGEN)
(Streptococcus
pyogenes) 		3 / 3 LYS A 234
LYS A  13
SER A  14
 None
 1.09A 5odiA-1bxtA:
undetectable		 5odiA-1bxtA:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7P_A_SAMA501_1
(OXAC)		 1bxt PROTEIN
(STREPTOCOCCAL
SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 5 TYR A  90
HIS A  31
ASP A  55
ASP A  62
 None
 1.32A 5w7pA-1bxtA:
undetectable		 5w7pA-1bxtA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1bxt PROTEIN
(STREPTOCOCCAL
SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 5 LEU A 164
LYS A 168
LEU A 231
GLU A 134
 None
 1.24A 5weaA-1bxtA:
undetectable		 5weaA-1bxtA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 1bxt PROTEIN
(STREPTOCOCCAL
SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 8 GLY A 111
GLN A 154
THR A 152
PHE A  51
 None
 1.16A 6eqpA-1bxtA:
undetectable		 6eqpA-1bxtA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JI6_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME)		 1bxt PROTEIN
(STREPTOCOCCAL
SUPERANTIGEN)
(Streptococcus
pyogenes) 		4 / 5 GLY A 181
LEU A 231
SER A 176
TYR A 171
 None
 1.07A 6ji6A-1bxtA:
undetectable		 6ji6A-1bxtA:
22.14