SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1bxz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_L_TRPL81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 9 VAL A 256
GLY A 235
ALA A 171
THR A 231
ILE A 255
 None
 1.10A 1gtnL-1bxzA:
undetectable
1gtnM-1bxzA:
undetectable		 1gtnL-1bxzA:
15.35
1gtnM-1bxzA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		4 / 8 THR A 231
VAL A 216
ASP A 214
VAL A 197
 None
 0.98A 1iwiA-1bxzA:
undetectable		 1iwiA-1bxzA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		3 / 3 ASP A  89
ASP A 128
LYS A 111
 None
 1.04A 1lqtB-1bxzA:
3.3		 1lqtB-1bxzA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1430_0
(FPRA)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		3 / 3 ASP A  89
ASP A 128
LYS A 111
 None
 1.06A 1lquB-1bxzA:
3.3		 1lquB-1bxzA:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SDT_B_MK1B902_1
(PROTEASE RETROPEPSIN)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 10 ILE A 248
GLY A 243
GLY A 174
ILE A 175
ILE A 223
 None
 0.99A 1sdtA-1bxzA:
undetectable		 1sdtA-1bxzA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		4 / 8 ALA A 206
ASP A 205
ILE A 175
ILE A 215
 None
 0.69A 1sh9A-1bxzA:
undetectable		 1sh9A-1bxzA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		4 / 6 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.61A 1wmqA-1bxzA:
0.0		 1wmqA-1bxzA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		4 / 6 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.62A 1wmqB-1bxzA:
undetectable		 1wmqB-1bxzA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		4 / 6 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.61A 1wpuA-1bxzA:
0.0		 1wpuA-1bxzA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		4 / 6 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.61A 1wpuB-1bxzA:
0.0		 1wpuB-1bxzA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		4 / 6 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.61A 1wrqA-1bxzA:
0.0		 1wrqA-1bxzA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		4 / 6 ILE A  86
GLY A 109
ALA A 108
HIS A 100
 None
 0.61A 1wrqB-1bxzA:
0.0		 1wrqB-1bxzA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XOZ_A_CIAA501_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 12 ALA A 263
ILE A 262
ILE A 240
VAL A 170
ILE A 227
 None
 0.93A 1xozA-1bxzA:
undetectable		 1xozA-1bxzA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 11 ASN A 266
VAL A 265
ILE A 262
ALA A 162
ASP A 247
 None
 1.03A 2iyfA-1bxzA:
4.5		 2iyfA-1bxzA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_B_ERYB1399_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 12 ASN A 266
VAL A 265
ILE A 262
ALA A 162
ASP A 247
 None
 1.16A 2iyfB-1bxzA:
5.9		 2iyfB-1bxzA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KCE_A_D16A566_2
(THYMIDYLATE SYNTHASE)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		3 / 3 HIS A  59
ILE A  49
LEU A 107
 SBT  A 353 ( 4.2A)
None
None
 0.77A 2kceA-1bxzA:
0.0		 2kceA-1bxzA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_3
(PROTEASE RETROPEPSIN)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		6 / 12 GLY A 155
ASN A 264
ILE A 241
GLY A 174
ILE A 175
VAL A 170
 None
 1.26A 2q64B-1bxzA:
undetectable		 2q64B-1bxzA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_A_SAMA301_0
(UPF0217 PROTEIN
AF_1056)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 9 LEU A 180
ILE A 175
GLY A 174
GLY A 243
CYH A 203
 None
 0.78A 2qmmA-1bxzA:
2.6		 2qmmA-1bxzA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMM_B_SAMB301_0
(UPF0217 PROTEIN
AF_1056)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 11 LEU A 180
ILE A 175
GLY A 174
GLY A 243
CYH A 203
 None
 0.82A 2qmmA-1bxzA:
2.2
2qmmB-1bxzA:
2.3		 2qmmA-1bxzA:
17.90
2qmmB-1bxzA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 8 ALA A 238
LEU A 173
ILE A 227
VAL A 197
ILE A 175
 None
 1.21A 2uxpA-1bxzA:
undetectable		 2uxpA-1bxzA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D1Z_B_017B201_1
(HIV-1 PROTEASE)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 12 GLY A 155
ILE A 241
GLY A 174
ILE A 175
VAL A 170
 None
 1.01A 3d1zA-1bxzA:
undetectable		 3d1zA-1bxzA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMF_A_SAMA388_0
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 12 GLY A  63
ALA A  33
ASP A  26
PRO A  84
PHE A 112
 None
 1.04A 3dmfA-1bxzA:
8.2		 3dmfA-1bxzA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FW3_B_ETSB303_1
(CARBONIC ANHYDRASE 4)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 12 GLN A 226
VAL A 216
ILE A 195
VAL A 197
THR A 251
 None
 1.00A 3fw3B-1bxzA:
0.0		 3fw3B-1bxzA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_C_DXCC92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		4 / 4 VAL A 349
PHE A 120
PHE A 112
VAL A  83
 None
 1.44A 3rv5C-1bxzA:
undetectable
3rv5D-1bxzA:
undetectable		 3rv5C-1bxzA:
14.08
3rv5D-1bxzA:
14.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_A_017A201_1
(PROTEASE)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		6 / 9 GLY A 211
ALA A 212
ASP A 214
ILE A 195
GLY A 192
ILE A 240
 None
 1.17A 3s53A-1bxzA:
undetectable		 3s53A-1bxzA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 12 GLY A 179
VAL A 204
ILE A 262
GLY A 158
ALA A 171
 None
 0.89A 3sufD-1bxzA:
undetectable		 3sufD-1bxzA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TMZ_A_06XA503_1
(CYTOCHROME P450 2B4)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 11 ILE A 290
PHE A 268
ILE A 248
VAL A 276
PRO A 277
 None
 1.10A 3tmzA-1bxzA:
undetectable		 3tmzA-1bxzA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_B_MIYB2001_1
(TETX2 PROTEIN)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		4 / 8 PHE A 268
HIS A  42
GLY A 269
GLY A 174
 None
 0.94A 3v3nB-1bxzA:
undetectable		 3v3nB-1bxzA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		4 / 8 PHE A 268
HIS A  42
GLY A 269
GLY A 174
 None
 0.95A 3v3nC-1bxzA:
undetectable		 3v3nC-1bxzA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1476_0
(MJ0495-LIKE PROTEIN)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		4 / 5 ILE A 306
ALA A 145
HIS A 135
ARG A  80
 None
 1.00A 4ac9B-1bxzA:
undetectable
4ac9C-1bxzA:
2.6		 4ac9B-1bxzA:
22.86
4ac9C-1bxzA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		4 / 5 ILE A 306
ALA A 145
HIS A 135
ARG A  80
 None
 0.98A 4acaB-1bxzA:
undetectable
4acaC-1bxzA:
2.7		 4acaB-1bxzA:
22.86
4acaC-1bxzA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DXU_A_ACAA711_1
(LACTOTRANSFERRIN)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 6 GLY A 260
VAL A 256
PRO A 258
GLY A 282
GLU A 280
 None
 1.16A 4dxuA-1bxzA:
undetectable		 4dxuA-1bxzA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		4 / 8 ILE A 350
ARG A 325
PRO A 316
VAL A 320
 None
 1.25A 4f4dB-1bxzA:
3.2		 4f4dB-1bxzA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		4 / 7 GLY A 260
VAL A 256
PRO A 258
GLY A 282
 None
 0.69A 4forA-1bxzA:
undetectable		 4forA-1bxzA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0S_A_AZMA302_1
(CARBONIC ANHYDRASE 2)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 11 GLN A 226
VAL A 216
LEU A 230
VAL A 197
THR A 251
 None
 1.26A 4k0sA-1bxzA:
undetectable		 4k0sA-1bxzA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 12 ALA A 242
GLY A 174
ILE A 240
GLY A 155
ASN A 264
 None
 1.15A 4obwA-1bxzA:
7.8		 4obwA-1bxzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_D_SAMD601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 12 ALA A 242
GLY A 174
ILE A 240
GLY A 155
ASN A 264
 None
 1.11A 4obwD-1bxzA:
6.9		 4obwD-1bxzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_A_STRA601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		4 / 6 ALA A 196
GLY A 176
ILE A 215
VAL A 202
 None
 0.80A 4r21A-1bxzA:
undetectable		 4r21A-1bxzA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_B_DB8B800_1
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 10 ALA A 196
GLY A 176
LEU A 180
ALA A 206
ASP A 205
 None
 1.18A 5ajqB-1bxzA:
undetectable		 5ajqB-1bxzA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IH0_A_ERYA404_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 12 ILE A 248
GLY A 174
GLU A 280
ALA A 263
ILE A 227
 None
 0.96A 5ih0A-1bxzA:
0.0		 5ih0A-1bxzA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_A_SAMA301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		3 / 3 GLY A  23
ASP A  26
ASN A 132
 None
 0.51A 5jglA-1bxzA:
7.9		 5jglA-1bxzA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		4 / 6 PHE A 112
VAL A  83
ALA A  85
THR A 153
 None
None
SBT  A 353 ( 4.4A)
None
 1.11A 5t7bA-1bxzA:
0.0		 5t7bA-1bxzA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC607_0
(ALPHA-AMYLASE)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 6 GLY A 109
ASP A  89
GLY A 297
PRO A 296
GLY A 298
 None
 1.47A 6ag0C-1bxzA:
undetectable		 6ag0C-1bxzA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 12 GLY A 179
VAL A 204
ILE A 262
GLY A 158
ALA A 171
 None
 0.93A 6c2mA-1bxzA:
undetectable		 6c2mA-1bxzA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		5 / 12 GLY A 179
VAL A 204
ILE A 262
GLY A 158
ALA A 171
 None
 0.91A 6c2mB-1bxzA:
0.1		 6c2mB-1bxzA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_D_EY4D500_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)		 1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE
(Thermoanaerobact
er
brockii) 		4 / 7 ILE A 240
VAL A 183
ALA A 212
THR A 213
 None
 0.96A 6cduC-1bxzA:
undetectable
6cduD-1bxzA:
undetectable		 6cduC-1bxzA:
21.04
6cduD-1bxzA:
21.04