SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1by1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLB_A_NVPA999_1
(HIV-1 RT A-CHAIN)		 1by1 PROTEIN (PIX)
(Homo
sapiens) 		4 / 8 LEU A  40
CYH A  65
LEU A 141
TYR A  39
 None
 0.91A 1jlbA-1by1A:
undetectable		 1jlbA-1by1A:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGZ_D_COCD401_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1by1 PROTEIN (PIX)
(Homo
sapiens) 		4 / 6 TYR A 103
TYR A 155
GLN A  68
ILE A  64
 None
 1.46A 2pgzD-1by1A:
undetectable
2pgzE-1by1A:
undetectable		 2pgzD-1by1A:
22.39
2pgzE-1by1A:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 1by1 PROTEIN (PIX)
(Homo
sapiens) 		5 / 12 ALA A 133
GLY A 144
SER A 135
GLY A 137
THR A  34
 None
 1.19A 4mm8A-1by1A:
undetectable		 4mm8A-1by1A:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1by1 PROTEIN (PIX)
(Homo
sapiens) 		3 / 3 ALA A 182
ASN A 185
LEU A 186
 None
 0.29A 5i1nC-1by1A:
0.0		 5i1nC-1by1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1N_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1by1 PROTEIN (PIX)
(Homo
sapiens) 		3 / 3 ALA A 182
ASN A 185
LEU A 186
 None
 0.36A 5i1nB-1by1A:
0.0		 5i1nB-1by1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1by1 PROTEIN (PIX)
(Homo
sapiens) 		3 / 3 ALA A 182
ASN A 185
LEU A 186
 None
 0.28A 5i1oC-1by1A:
0.0		 5i1oC-1by1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1O_H_DVAH9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1by1 PROTEIN (PIX)
(Homo
sapiens) 		3 / 3 ALA A 182
ASN A 185
LEU A 186
 None
 0.45A 5i1oA-1by1A:
0.0		 5i1oA-1by1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_F_DVAF9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1by1 PROTEIN (PIX)
(Homo
sapiens) 		3 / 3 ALA A 182
ASN A 185
LEU A 186
 None
 0.24A 5i1pA-1by1A:
0.0		 5i1pA-1by1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I1P_G_DVAG9_0
(D-VILLIN HEADPIECE
SUBDOMAIN
VILLIN-1)		 1by1 PROTEIN (PIX)
(Homo
sapiens) 		3 / 3 ALA A 182
ASN A 185
LEU A 186
 None
 0.30A 5i1pD-1by1A:
0.0		 5i1pD-1by1A:
11.38