SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1by2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_H_DHIH3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 1by2 MAC-2 BINDING
PROTEIN
(Homo
sapiens) 		3 / 3 LEU A  37
TRP A  35
GLY A 102
 None
 0.75A 3l35A-1by2A:
undetectable
3l35H-1by2A:
undetectable		 3l35A-1by2A:
9.40
3l35H-1by2A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L35_K_DHIK3_0
(GP41 N-PEPTIDE
HIV ENTRY INHIBITOR
PIE12)		 1by2 MAC-2 BINDING
PROTEIN
(Homo
sapiens) 		3 / 3 LEU A  37
TRP A  35
GLY A 102
 None
 0.77A 3l35B-1by2A:
undetectable
3l35K-1by2A:
undetectable		 3l35B-1by2A:
9.40
3l35K-1by2A:
8.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 1by2 MAC-2 BINDING
PROTEIN
(Homo
sapiens) 		4 / 7 ASP A  39
THR A  76
LEU A  70
LYS A  92
 None
 1.11A 4ib4A-1by2A:
undetectable		 4ib4A-1by2A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1by2 MAC-2 BINDING
PROTEIN
(Homo
sapiens) 		5 / 9 ALA A  52
THR A  53
VAL A  19
GLY A 102
ASP A  36
 None
 1.17A 4qvnK-1by2A:
undetectable
4qvnL-1by2A:
undetectable		 4qvnK-1by2A:
21.43
4qvnL-1by2A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 1by2 MAC-2 BINDING
PROTEIN
(Homo
sapiens) 		5 / 9 ALA A  52
THR A  53
VAL A  19
GLY A 102
ASP A  36
 None
 1.17A 4qvnY-1by2A:
undetectable
4qvnZ-1by2A:
undetectable		 4qvnY-1by2A:
21.43
4qvnZ-1by2A:
19.28