SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1by4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1by4 PROTEIN (RETINOIC
ACID RECEPTOR
RXR-ALPHA)
(Homo
sapiens) 		3 / 3 LEU A1167
LEU A1196
MET A1200
 None
 0.75A 2itzA-1by4A:
undetectable		 2itzA-1by4A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 1by4 PROTEIN (RETINOIC
ACID RECEPTOR
RXR-ALPHA)
(Homo
sapiens) 		4 / 5 ALA A1136
GLY A1154
CYH A1155
LYS A1156
 None
None
ZN  A1330 (-2.2A)
None
 1.20A 2yldA-1by4A:
undetectable		 2yldA-1by4A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 1by4 PROTEIN (RETINOIC
ACID RECEPTOR
RXR-ALPHA)
(Homo
sapiens) 		4 / 5 ALA A1136
GLY A1154
CYH A1155
LYS A1156
 None
None
ZN  A1330 (-2.2A)
None
 1.18A 2ylgA-1by4A:
undetectable		 2ylgA-1by4A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 1by4 PROTEIN (RETINOIC
ACID RECEPTOR
RXR-ALPHA)
(Homo
sapiens) 		4 / 5 ALA A1136
GLY A1154
CYH A1155
LYS A1156
 None
None
ZN  A1330 (-2.2A)
None
 1.13A 5jliA-1by4A:
undetectable		 5jliA-1by4A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 1by4 PROTEIN (RETINOIC
ACID RECEPTOR
RXR-ALPHA)
(Homo
sapiens) 		5 / 12 GLY A1154
ASN A1185
THR A1162
TYR A1169
TYR A1147
 None
 1.35A 5yf0A-1by4A:
undetectable		 5yf0A-1by4A:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1by4 PROTEIN (RETINOIC
ACID RECEPTOR
RXR-ALPHA)
(Homo
sapiens) 		4 / 8 LYS A1181
ARG A1184
VAL A1149
ARG A1161
 None
ZN  A1330 ( 4.6A)
None
None
 1.23A 6fbvD-1by4A:
undetectable		 6fbvD-1by4A:
4.60