SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1by7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM9_A_9CRA201_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		3 / 3 GLN A  59
ILE A 114
HIS A 400
 None
 0.65A 1fm9A-1by7A:
undetectable		 1fm9A-1by7A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		4 / 8 PHE A 212
PHE A 312
LEU A 256
VAL A 307
 None
 0.87A 1fslA-1by7A:
0.0		 1fslA-1by7A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_B_NIOB145_1
(LEGHEMOGLOBIN A)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		4 / 8 PHE A 212
PHE A 312
LEU A 256
VAL A 307
 None
 0.90A 1fslB-1by7A:
undetectable		 1fslB-1by7A:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		3 / 3 GLN A  59
ILE A 114
HIS A 400
 None
 0.65A 1k74A-1by7A:
undetectable		 1k74A-1by7A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_A_NCTA1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		4 / 8 TYR A 141
THR A  38
TYR A 149
LEU A  58
 None
 1.39A 1uw6A-1by7A:
0.0
1uw6B-1by7A:
0.0		 1uw6A-1by7A:
19.13
1uw6B-1by7A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_D_NCTD1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		4 / 8 TYR A 141
THR A  38
TYR A 149
LEU A  58
 None
 1.40A 1uw6D-1by7A:
0.0
1uw6E-1by7A:
0.0		 1uw6D-1by7A:
19.13
1uw6E-1by7A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_G_NCTG1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		4 / 8 TYR A 141
THR A  38
TYR A 149
LEU A  58
 None
 1.41A 1uw6G-1by7A:
0.0
1uw6H-1by7A:
0.0		 1uw6G-1by7A:
19.13
1uw6H-1by7A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_P_NCTP1206_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		4 / 8 TYR A 141
THR A  38
TYR A 149
LEU A  58
 None
 1.39A 1uw6P-1by7A:
0.0
1uw6Q-1by7A:
0.0		 1uw6P-1by7A:
19.13
1uw6Q-1by7A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UW6_T_NCTT1208_1
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		4 / 8 LEU A  58
TYR A 141
THR A  38
TYR A 149
 None
 1.39A 1uw6P-1by7A:
0.0
1uw6T-1by7A:
0.0		 1uw6P-1by7A:
19.13
1uw6T-1by7A:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		5 / 12 LEU A 314
ALA A 358
PHE A  16
ILE A 406
PHE A 396
 None
 1.05A 3b2rA-1by7A:
undetectable		 3b2rA-1by7A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		5 / 9 ILE A 114
LEU A 407
PHE A 204
LYS A 207
GLY A 206
 None
 1.47A 3sj4X-1by7A:
undetectable		 3sj4X-1by7A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		3 / 3 THR A 194
VAL A 197
GLU A 132
 None
 0.75A 3v4tA-1by7A:
0.0
3v4tD-1by7A:
undetectable		 3v4tA-1by7A:
21.85
3v4tD-1by7A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		4 / 8 VAL A 173
ILE A 169
ASN A 170
GLU A 315
 None
 1.10A 4a97D-1by7A:
undetectable		 4a97D-1by7A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HAJ_A_DXCA75_0
(PPCA)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		5 / 7 ILE A 114
LEU A 407
PHE A 204
LYS A 207
GLY A 206
 None
 1.48A 4hajA-1by7A:
undetectable		 4hajA-1by7A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZT_B_ACTB201_0
(RETINOL-BINDING
PROTEIN 2)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		4 / 5 TYR A 318
GLU A 316
LEU A  19
GLN A  26
 None
 1.12A 4qztB-1by7A:
0.0		 4qztB-1by7A:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		5 / 12 ILE A 114
THR A 177
ALA A 201
ALA A 358
ASN A 200
 None
 1.48A 4u14A-1by7A:
undetectable		 4u14A-1by7A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WQ5_B_ACTB404_0
(TRNA N6-ADENOSINE
THREONYLCARBAMOYLTRA
NSFERASE)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		3 / 3 TYR A 148
ARG A 143
LYS A 147
 None
 1.19A 4wq5B-1by7A:
0.0		 4wq5B-1by7A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_D_ACTD403_0
(PROTON-GATED ION
CHANNEL)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		4 / 4 ILE A 103
ARG A  47
TYR A  43
GLU A  51
 None
 1.14A 4zzbD-1by7A:
undetectable		 4zzbD-1by7A:
25.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		4 / 5 ILE A 103
ARG A  47
TYR A  43
GLU A  51
 None
 1.09A 4zzcE-1by7A:
0.0		 4zzcE-1by7A:
26.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		5 / 9 GLY A 131
GLN A 176
ASN A 127
LEU A 198
LEU A 351
 None
 1.38A 5fhzB-1by7A:
undetectable		 5fhzB-1by7A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_C_REAC602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		5 / 10 GLY A 131
GLN A 176
ASN A 127
LEU A 198
LEU A 351
 None
 1.27A 5fhzC-1by7A:
0.0		 5fhzC-1by7A:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_2
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		3 / 3 GLN A  59
ILE A 114
HIS A 400
 None
 0.58A 5z12B-1by7A:
0.0		 5z12B-1by7A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBF_A_ACTA507_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 1by7 PROTEIN (PLASMINOGEN
ACTIVATOR
INHIBITOR-2)
(Homo
sapiens) 		3 / 3 LYS A  99
SER A 105
SER A 106
 None
 1.13A 6gbfA-1by7A:
undetectable		 6gbfA-1by7A:
21.95