SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c07'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4I89_A_1FLA201_1 (TRANSTHYRETIN)	1c07	PROTEIN (EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE 15) (Homo sapiens)	4 / 6	LEU A 80 LEU A 60 SER A 59 THR A 63	None	1.02A	4i89A-1c07A: undetectable	4i89A-1c07A: 23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4Y0Q_A_PX9A201_1 (BETA-LACTOGLOBULIN)	1c07	PROTEIN (EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE 15) (Homo sapiens)	3 / 3	LYS A 19 ILE A 23 ILE A 43	None	0.68A	4y0qA-1c07A: undetectable	4y0qA-1c07A: 18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5G5G_C_ACTC1740_0 (PUTATIVE XANTHINE DEHYDROGENASE YAGS FAD-BINDING SUBUNIT)	1c07	PROTEIN (EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE 15) (Homo sapiens)	4 / 4	VAL A 40 GLU A 39 GLY A 37 LEU A 69	None CA A 110 (-2.4A) None None	1.33A	5g5gC-1c07A: undetectable	5g5gC-1c07A: 10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5L4I_A_6J3A201_0 (TRANSTHYRETIN)	1c07	PROTEIN (EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE 15) (Homo sapiens)	4 / 6	LEU A 80 LEU A 60 SER A 59 THR A 63	None	1.02A	5l4iA-1c07A: undetectable	5l4iA-1c07A: 23.70

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4I89_A_1FLA201_1","TRANSTHYRETIN","1c07","PROTEIN (EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE 15)","Homo sapiens",4,"LEU A  80;LEU A  60;SER A  59;THR A  63","None","1.02A","4i89A-1c07A:undetectable","4i89A-1c07A:23.70"],["4Y0Q_A_PX9A201_1","BETA-LACTOGLOBULIN","1c07","PROTEIN (EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE 15)","Homo sapiens",3,"LYS A  19;ILE A  23;ILE A  43","None","0.68A","4y0qA-1c07A:undetectable","4y0qA-1c07A:18.52"],["5G5G_C_ACTC1740_0","PUTATIVE XANTHINE DEHYDROGENASE YAGS FAD-BINDING SUBUNIT","1c07","PROTEIN (EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE 15)","Homo sapiens",4,"VAL A  40;GLU A  39;GLY A  37;LEU A  69","None; CA A 110 (-2.4A);None;None","1.33A","5g5gC-1c07A:undetectable","5g5gC-1c07A:10.43"],["5L4I_A_6J3A201_0","TRANSTHYRETIN","1c07","PROTEIN (EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY SUBSTRATE 15)","Homo sapiens",4,"LEU A  80;LEU A  60;SER A  59;THR A  63","None","1.02A","5l4iA-1c07A:undetectable","5l4iA-1c07A:23.70"]]