SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c0i'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_A_IBPA701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		5 / 9 VAL A1176
ILE A1032
ALA A1020
SER A1019
LEU A1023
 None
 1.18A 1eqgA-1c0iA:
0.0		 1eqgA-1c0iA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		3 / 3 TRP A1342
VAL A1079
TRP A1078
 None
 0.92A 1gmkC-1c0iA:
undetectable
1gmkD-1c0iA:
undetectable		 1gmkC-1c0iA:
3.56
1gmkD-1c0iA:
3.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3004_1
(SERUM ALBUMIN)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		4 / 7 ALA A1296
GLU A1295
LEU A1327
VAL A1175
 None
 0.93A 1hk2A-1c0iA:
0.0		 1hk2A-1c0iA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_1
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		4 / 4 ILE A1022
LEU A1023
VAL A1009
ALA A1168
 None
 0.94A 1mz9A-1c0iA:
undetectable		 1mz9A-1c0iA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		4 / 5 ILE A1022
LEU A1023
VAL A1009
ALA A1168
 None
 0.96A 1mz9C-1c0iA:
0.0		 1mz9C-1c0iA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		4 / 6 ILE A1299
VAL A1325
ILE A1032
ASP A1170
 None
 0.85A 1uwhB-1c0iA:
undetectable		 1uwhB-1c0iA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XF1_A_ACTA1107_0
(C5A PEPTIDASE)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		4 / 5 LEU A1103
GLY A1102
ILE A1128
PHE A1096
 None
 0.99A 1xf1A-1c0iA:
undetectable		 1xf1A-1c0iA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		3 / 3 ASP A1036
ILE A1186
VAL A1008
 FAD  A1363 (-3.4A)
FAD  A1363 (-4.7A)
None
 0.59A 2avvD-1c0iA:
0.0		 2avvD-1c0iA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_B_HSMB1160_1
(ALLERGEN ARG R 1)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		4 / 7 SER A1019
VAL A1294
ILE A1015
TRP A1070
 None
None
FAD  A1363 (-4.0A)
None
 1.25A 2x45B-1c0iA:
undetectable		 2x45B-1c0iA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X45_C_HSMC1160_1
(ALLERGEN ARG R 1)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		4 / 7 SER A1019
VAL A1294
ILE A1015
TRP A1070
 None
None
FAD  A1363 (-4.0A)
None
 1.24A 2x45C-1c0iA:
undetectable		 2x45C-1c0iA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARR_A_PNXA606_1
(CHITINASE A)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		4 / 7 GLY A1188
LYS A1307
ASP A1191
ARG A1288
 None
 1.11A 3arrA-1c0iA:
undetectable		 3arrA-1c0iA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ARU_A_PNXA606_1
(CHITINASE A)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		4 / 7 GLY A1188
LYS A1307
ASP A1191
ARG A1288
 None
 1.04A 3aruA-1c0iA:
undetectable		 3aruA-1c0iA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		5 / 12 ALA A1222
ILE A1224
THR A1093
LEU A1118
PRO A1119
 None
 1.19A 3cl9A-1c0iA:
undetectable		 3cl9A-1c0iA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM6_A_017A200_1
(PROTEASE)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		5 / 8 GLY A1182
ALA A1183
ASP A1191
GLY A1188
VAL A1176
 FAD  A1363 (-3.4A)
None
None
None
None
 1.23A 3em6A-1c0iA:
0.0		 3em6A-1c0iA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RGF_A_BAXA465_2
(CYCLIN-DEPENDENT
KINASE 8)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		4 / 7 LEU A1010
VAL A1175
VAL A1162
ASP A1170
 None
None
FAD  A1363 (-4.0A)
None
 0.86A 3rgfA-1c0iA:
0.0		 3rgfA-1c0iA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		4 / 8 TYR A1108
LEU A1103
ALA A1097
SER A1215
 None
 1.02A 3rodA-1c0iA:
undetectable		 3rodA-1c0iA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_B_NCAB302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		5 / 9 TYR A1108
TYR A1132
LEU A1103
ALA A1097
SER A1215
 None
 1.21A 3rodB-1c0iA:
2.1		 3rodB-1c0iA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		5 / 12 PHE A1157
LEU A1021
GLY A1013
GLY A1016
VAL A1009
 None
None
FAD  A1363 (-3.3A)
None
None
 1.13A 4a6dA-1c0iA:
0.0		 4a6dA-1c0iA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		5 / 12 PHE A1157
LEU A1021
GLY A1013
GLY A1016
VAL A1009
 None
None
FAD  A1363 (-3.3A)
None
None
 1.13A 4a6eA-1c0iA:
undetectable		 4a6eA-1c0iA:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZS_A_SAMA1475_0
(METHYLTRANSFERASE
WBDD)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		5 / 12 GLY A1011
ALA A1178
ARG A1160
GLU A1158
LEU A1017
 FAD  A1363 (-3.4A)
None
None
None
None
 1.26A 4azsA-1c0iA:
undetectable		 4azsA-1c0iA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		5 / 10 VAL A1294
GLY A1337
PHE A1333
GLY A1291
ASP A1347
 None
FAD  A1363 (-3.1A)
None
None
None
 1.42A 4mmcA-1c0iA:
0.0		 4mmcA-1c0iA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_D_SAMD301_1
(UNCHARACTERIZED
PROTEIN)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		3 / 3 ARG A1288
GLU A1297
TYR A1331
 None
 0.92A 4r29D-1c0iA:
0.0		 4r29D-1c0iA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_C7HA402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		4 / 5 TYR A1132
GLY A1129
TYR A1108
GLY A1105
 None
 1.06A 5ayfA-1c0iA:
0.0		 5ayfA-1c0iA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		5 / 12 GLN A1253
VAL A1252
HIS A1280
VAL A1204
GLY A1274
 None
 1.24A 5i8fA-1c0iA:
0.0		 5i8fA-1c0iA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 1c0i D-AMINO ACID OXIDASE
(Rhodotorula
toruloides) 		3 / 3 PRO A1119
SER A1120
SER A1121
 None
 0.65A 6bpyA-1c0iA:
8.7		 6bpyA-1c0iA:
22.63