SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c0n'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		5 / 8 GLY A 201
GLY A 234
PHE A 222
SER A 223
GLY A  97
 None
None
None
PLP  A 500 (-2.5A)
None
 1.50A 1jhqA-1c0nA:
0.0		 1jhqA-1c0nA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K5Q_B_PACB559_0
(PENICILLIN G ACYLASE
ALPHA SUBUNIT
PENICILLIN G ACYLASE
BETA SUBUNIT)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		4 / 7 SER A 381
ALA A 383
TYR A 385
ALA A  30
 None
None
None
ACY  A 550 ( 4.9A)
 0.89A 1k5qA-1c0nA:
0.2
1k5qB-1c0nA:
undetectable		 1k5qA-1c0nA:
20.35
1k5qB-1c0nA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_B_CHDB500_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		4 / 4 LEU A 198
VAL A 199
ILE A 170
TRP A 130
 None
 1.40A 1s9qB-1c0nA:
0.0		 1s9qB-1c0nA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FCN_B_DVAB35_0
(UBIQUITIN)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		4 / 6 GLN A 120
GLU A 122
ILE A 144
PRO A 145
 None
 1.11A 2fcnA-1c0nA:
0.0
2fcnB-1c0nA:
0.0		 2fcnA-1c0nA:
11.22
2fcnB-1c0nA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		5 / 12 ARG A  83
ILE A  80
ILE A 235
ALA A 270
GLU A 240
 None
 1.04A 2j0dA-1c0nA:
0.0		 2j0dA-1c0nA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_B_RALB600_1
(ESTROGEN RECEPTOR)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		5 / 12 ALA A 380
LEU A 382
LEU A  27
GLY A 397
LEU A 398
 None
 1.12A 2jfaB-1c0nA:
undetectable		 2jfaB-1c0nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBO_A_CAMA442_0
(CYTOCHROME P450-CAM)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		5 / 10 THR A  94
VAL A 199
VAL A 205
ILE A  80
VAL A 210
 PLP  A 500 (-3.9A)
None
None
None
None
 1.44A 2qboA-1c0nA:
0.0		 2qboA-1c0nA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_B_1UNB900_1
(PROTEASE)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		5 / 9 LEU A 198
GLY A 234
ILE A 235
VAL A 101
ILE A  98
 None
 1.13A 2r5qA-1c0nA:
undetectable		 2r5qA-1c0nA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2R5Q_D_1UND900_1
(PROTEASE)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		5 / 9 LEU A 198
GLY A 234
ILE A 235
VAL A 101
ILE A  98
 None
 1.13A 2r5qC-1c0nA:
undetectable		 2r5qC-1c0nA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		4 / 8 LEU A 317
VAL A 320
VAL A 347
LEU A 351
 None
 0.89A 2zujA-1c0nA:
0.0		 2zujA-1c0nA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_1
(CATECHOL
O-METHYLTRANSFERASE)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		4 / 6 GLY A 224
SER A  32
ILE A 233
ILE A 235
 None
 0.95A 3a7eA-1c0nA:
3.5		 3a7eA-1c0nA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		4 / 8 ALA A 190
LEU A 168
ASP A 218
ASP A 216
 None
 0.76A 3qj7A-1c0nA:
0.0
3qj7D-1c0nA:
0.0		 3qj7A-1c0nA:
21.74
3qj7D-1c0nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_D_D16D301_1
(THYMIDYLATE SYNTHASE)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		5 / 12 ILE A 235
LEU A 227
GLY A 224
VAL A 205
ALA A 204
 None
 1.21A 4foxD-1c0nA:
0.0		 4foxD-1c0nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_A_LYAA302_1
(THYMIDYLATE SYNTHASE)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		5 / 12 ILE A 235
LEU A 227
GLY A 224
VAL A 205
ALA A 204
 None
 1.23A 4fqsA-1c0nA:
0.0		 4fqsA-1c0nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FQS_B_LYAB302_1
(THYMIDYLATE SYNTHASE)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		5 / 12 ILE A 235
LEU A 227
GLY A 224
VAL A 205
ALA A 204
 None
 1.23A 4fqsB-1c0nA:
0.0		 4fqsB-1c0nA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		5 / 12 ILE A  98
GLY A  93
GLY A  97
ILE A 235
ILE A 233
 None
PLP  A 500 ( 4.2A)
None
None
None
 1.15A 4iv0B-1c0nA:
2.8		 4iv0B-1c0nA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		4 / 5 LEU A 157
PRO A 158
LEU A 160
ILE A 144
 None
 0.98A 4klrA-1c0nA:
undetectable		 4klrA-1c0nA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		4 / 5 TYR A 385
LEU A 309
GLU A 306
TYR A 305
 None
 1.29A 4olaA-1c0nA:
0.0		 4olaA-1c0nA:
18.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5DB5_A_CYSA503_0
(CYSTEINE DESULFURASE)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		5 / 8 ALA A  31
HIS A 123
ASN A 175
LYS A 226
ARG A 379
 ACY  A 550 (-3.6A)
PLP  A 500 (-3.7A)
ACY  A 550 (-3.7A)
PLP  A 500 (-1.3A)
ACY  A 550 (-2.5A)
 0.31A 5db5A-1c0nA:
65.6
5db5B-1c0nA:
65.8		 5db5A-1c0nA:
98.28
5db5B-1c0nA:
98.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_O_BEZO801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		4 / 6 PHE A  90
HIS A  55
PRO A 279
MET A  69
 None
 1.36A 5dzka-1c0nA:
undetectable
5dzko-1c0nA:
undetectable		 5dzka-1c0nA:
19.80
5dzko-1c0nA:
1.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESL_A_1YNA701_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		5 / 12 GLY A 194
TYR A 237
ILE A 235
GLY A 201
HIS A 191
 None
 1.30A 5eslA-1c0nA:
undetectable		 5eslA-1c0nA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JS1_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		4 / 5 TYR A 385
LEU A 309
GLU A 306
TYR A 305
 None
 1.27A 5js1A-1c0nA:
0.0		 5js1A-1c0nA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_B_SAMB501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		5 / 12 LEU A 287
ALA A 289
ILE A 284
GLY A 282
LEU A 291
 None
 1.19A 5nfjB-1c0nA:
undetectable		 5nfjB-1c0nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NFJ_C_SAMC501_0
(MITOCHONDRIAL
RIBONUCLEASE P
PROTEIN 1)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		5 / 12 LEU A 287
ALA A 289
ILE A 284
GLY A 282
LEU A 291
 None
 1.17A 5nfjC-1c0nA:
undetectable		 5nfjC-1c0nA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_D_BEZD201_0
(NS3 PROTEASE)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		4 / 5 HIS A  59
ALA A  53
SER A  62
GLY A  57
 None
 1.11A 5yodD-1c0nA:
undetectable		 5yodD-1c0nA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		4 / 6 PHE A   3
TYR A 228
LEU A  15
SER A  29
 None
 1.24A 6a7pB-1c0nA:
undetectable		 6a7pB-1c0nA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRY_A_H8DA2001_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		6 / 11 VAL A 358
THR A 360
VAL A 391
LEU A 394
ALA A 344
VAL A 334
 None
 1.41A 6dryA-1c0nA:
undetectable		 6dryA-1c0nA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EFN_A_SAMA501_0
(SPORULATION KILLING
FACTOR MATURATION
PROTEIN SKFB)		 1c0n PROTEIN (CSDB
PROTEIN)
(Escherichia
coli) 		5 / 11 GLU A 390
SER A  29
ALA A  33
LEU A 299
ALA A 303
 None
 1.31A 6efnA-1c0nA:
undetectable		 6efnA-1c0nA:
22.30