SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c1d'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA155_1
(CALMODULIN)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		4 / 7 GLN A  33
PHE A 137
MET A  67
ALA A  68
 None
 1.00A 1linA-1c1dA:
undetectable		 1linA-1c1dA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		3 / 3 ARG A 277
VAL A 243
GLY A 259
 None
 0.65A 2avvE-1c1dA:
0.0		 2avvE-1c1dA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		3 / 3 LYS A  66
ASP A  55
ASN A 262
 PHE  A 361 (-2.6A)
None
PHE  A 361 ( 3.1A)
 1.12A 2bm9A-1c1dA:
3.6		 2bm9A-1c1dA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_A_EAAA0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		4 / 8 PHE A 137
ILE A 106
TYR A 113
GLY A  39
 None
None
None
PHE  A 361 (-3.7A)
 0.92A 2gssA-1c1dA:
undetectable		 2gssA-1c1dA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GSS_B_EAAB0_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		4 / 8 PHE A 137
ILE A 106
TYR A 113
GLY A  39
 None
None
None
PHE  A 361 (-3.7A)
 0.92A 2gssB-1c1dA:
undetectable		 2gssB-1c1dA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_B_J01B1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		5 / 12 ILE A 315
ALA A 160
ALA A 282
THR A 153
LEU A 190
 None
None
None
NAI  A 360 (-3.2A)
None
 1.26A 2japB-1c1dA:
7.1		 2japB-1c1dA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JAP_D_J01D1249_1
(CLAVALDEHYDE
DEHYDROGENASE)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		5 / 12 ILE A 315
ALA A 160
ALA A 282
THR A 153
LEU A 190
 None
None
None
NAI  A 360 (-3.2A)
None
 1.25A 2japD-1c1dA:
7.2		 2japD-1c1dA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XCT_G_CPFG1020_1
(DNA GYRASE SUBUNIT
B, DNA GYRASE
SUBUNIT A)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		3 / 3 ARG A 344
GLY A 342
SER A  31
 None
 0.64A 2xctB-1c1dA:
undetectable		 2xctB-1c1dA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		5 / 12 GLY A 187
GLY A 182
LEU A 190
ALA A 260
ALA A 154
 None
NAI  A 360 (-3.6A)
None
NAI  A 360 (-3.7A)
None
 0.92A 2yqzA-1c1dA:
7.3		 2yqzA-1c1dA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		5 / 12 GLY A 187
GLY A 182
LEU A 190
ALA A 260
ALA A 154
 None
NAI  A 360 (-3.6A)
None
NAI  A 360 (-3.7A)
None
 0.92A 2yqzB-1c1dA:
7.3		 2yqzB-1c1dA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N9J_A_EAAA210_1
(GLUTATHIONE
S-TRANSFERASE P)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		4 / 8 PHE A 137
ILE A 106
TYR A 113
GLY A  39
 None
None
None
PHE  A 361 (-3.7A)
 0.96A 3n9jA-1c1dA:
undetectable		 3n9jA-1c1dA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		5 / 12 GLY A 187
ILE A 315
GLY A 259
ALA A 260
ALA A 289
 None
None
None
NAI  A 360 (-3.7A)
None
 0.96A 3sudC-1c1dA:
undetectable		 3sudC-1c1dA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		5 / 7 THR A  41
GLY A 116
TYR A 113
GLY A  76
THR A  64
 None
PHE  A 361 ( 3.7A)
None
None
None
 1.31A 3tajA-1c1dA:
undetectable		 3tajA-1c1dA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V3N_C_MIYC2001_1
(TETX2 PROTEIN)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		4 / 8 PHE A 137
GLY A 138
GLY A 302
MET A  74
 None
K  A 853 (-4.1A)
None
None
 1.01A 3v3nC-1c1dA:
4.0		 3v3nC-1c1dA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		5 / 12 ILE A  81
LEU A  99
GLY A  39
GLY A  40
LEU A 129
 None
None
PHE  A 361 (-3.7A)
PHE  A 361 (-3.8A)
None
 1.11A 3vasB-1c1dA:
2.0		 3vasB-1c1dA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_B_SAMB601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		5 / 12 ASN A 262
ALA A  38
GLY A  76
GLY A  77
PHE A 137
 PHE  A 361 ( 3.1A)
PHE  A 361 ( 4.2A)
None
None
None
 1.03A 4obwB-1c1dA:
6.0		 4obwB-1c1dA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_NPSA602_1
(SERUM ALBUMIN)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		4 / 6 ALA A  43
ASP A 125
LEU A  83
SER A  89
 None
 1.13A 4ot2A-1c1dA:
undetectable		 4ot2A-1c1dA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		5 / 12 ASP A 131
HIS A 102
ASN A 130
THR A 115
SER A  79
 None
 1.29A 4pooA-1c1dA:
6.1		 4pooA-1c1dA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		5 / 12 ALA A 287
GLY A 156
GLY A 316
GLY A 259
LEU A 280
 None
 0.95A 5gwxA-1c1dA:
6.2		 5gwxA-1c1dA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXC_A_ZITA307_1
(PREDICTED
AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		4 / 5 ASP A 329
GLU A 268
ARG A 338
THR A 332
 None
 1.17A 5uxcA-1c1dA:
0.0		 5uxcA-1c1dA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YOD_B_BEZB201_0
(NS3 PROTEASE)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		4 / 5 HIS A 275
ALA A 336
SER A 326
GLY A 330
 None
 1.21A 5yodB-1c1dA:
0.0		 5yodB-1c1dA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1c1d L-PHENYLALANINE
DEHYDROGENASE
(Rhodococcus
sp.) 		4 / 8 ASP A 127
HIS A 294
ARG A 139
GLU A 299
 None
None
K  A 853 (-4.4A)
K  A 853 (-2.7A)
 1.12A 6mn4C-1c1dA:
2.4		 6mn4C-1c1dA:
22.57