SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c1e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2M2P_B_DHIB24_0 (INSULIN B CHAIN)	1c1e	CATALYTIC ANTIBODY 1E9 (HEAVY CHAIN) (Mus musculus)	3 / 3	TYR H 185 GLY H 146 PHE H 148	None	0.69A	2m2pB-1c1eH: undetectable	2m2pB-1c1eH: 13.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	2O5Y_H_STRH249_1 (CHIMERIC ANTIBODY FAB 1E9-DB3)	1c1e	CATALYTIC ANTIBODY 1E9 (HEAVY CHAIN) (Mus musculus)	4 / 7	ASN H 35 GLY H 95 THR H 97 MET H 100	ENH H 703 (-3.0A) ENH H 703 (-3.3A) ENH H 703 (-4.6A) ENH H 703 (-3.9A)	0.46A	2o5yH-1c1eH: 23.8 2o5yL-1c1eH: 16.2	2o5yH-1c1eH: 81.36 2o5yL-1c1eH: 28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y03_A_5FWA601_1 (BETA-1 ADRENERGIC RECEPTOR)	1c1e	CATALYTIC ANTIBODY 1E9 (HEAVY CHAIN) (Mus musculus)	5 / 12	VAL H 171 VAL H 191 SER H 189 ASN H 209 ASN H 162	None	1.40A	2y03A-1c1eH: undetectable	2y03A-1c1eH: 18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2Y03_B_5FWB601_1 (BETA-1 ADRENERGIC RECEPTOR)	1c1e	CATALYTIC ANTIBODY 1E9 (HEAVY CHAIN) (Mus musculus)	5 / 12	VAL H 171 VAL H 191 SER H 189 ASN H 209 ASN H 162	None	1.42A	2y03B-1c1eH: undetectable	2y03B-1c1eH: 18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4G19_D_ACTD305_0 (GLUTATHIONE TRANSFERASE GTE1)	1c1e	CATALYTIC ANTIBODY 1E9 (HEAVY CHAIN) (Mus musculus)	4 / 4	ILE H 82 LEU H 80 LYS H 19 ASN H 82	None	1.36A	4g19D-1c1eH: 0.0	4g19D-1c1eH: 22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LDO_A_ALEA1402_1 (LYSOZYME, BETA-2 ADRENERGIC RECEPTOR)	1c1e	CATALYTIC ANTIBODY 1E9 (HEAVY CHAIN) (Mus musculus)	5 / 10	VAL H 171 VAL H 191 SER H 189 ASN H 209 ASN H 162	None	1.46A	4ldoA-1c1eH: 0.0	4ldoA-1c1eH: 20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4LMN_A_EUIA503_2 (DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1)	1c1e	CATALYTIC ANTIBODY 1E9 (HEAVY CHAIN) (Mus musculus)	3 / 3	ASP H 183 VAL H 177 ASN H 84	None	0.76A	4lmnA-1c1eH: 0.0	4lmnA-1c1eH: 22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5XIW_D_LOCD503_1 (TUBULIN ALPHA-1B CHAIN TUBULIN BETA CHAIN)	1c1e	CATALYTIC ANTIBODY 1E9 (HEAVY CHAIN) (Mus musculus)	3 / 3	SER H 216 ALA H 211 VAL H 210	None	0.51A	5xiwC-1c1eH: undetectable	5xiwC-1c1eH: 14.93

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["2M2P_B_DHIB24_0","INSULIN B CHAIN","1c1e","CATALYTIC ANTIBODY 1E9 (HEAVY CHAIN)","Mus musculus",3,"TYR H 185;GLY H 146;PHE H 148","None","0.69A","2m2pB-1c1eH:undetectable","2m2pB-1c1eH:13.18"],["2O5Y_H_STRH249_1","CHIMERIC ANTIBODY FAB 1E9-DB3;CHIMERIC ANTIBODY FAB 1E9-DB3","1c1e","CATALYTIC ANTIBODY 1E9 (HEAVY CHAIN)","Mus musculus",4,"ASN H  35;GLY H  95;THR H  97;MET H 100","ENH H 703 (-3.0A);ENH H 703 (-3.3A);ENH H 703 (-4.6A);ENH H 703 (-3.9A)","0.46A","2o5yH-1c1eH:23.8;2o5yL-1c1eH:16.2","2o5yH-1c1eH:81.36;2o5yL-1c1eH:28.09"],["2Y03_A_5FWA601_1","BETA-1 ADRENERGIC RECEPTOR","1c1e","CATALYTIC ANTIBODY 1E9 (HEAVY CHAIN)","Mus musculus",5,"VAL H 171;VAL H 191;SER H 189;ASN H 209;ASN H 162","None","1.40A","2y03A-1c1eH:undetectable","2y03A-1c1eH:18.94"],["2Y03_B_5FWB601_1","BETA-1 ADRENERGIC RECEPTOR","1c1e","CATALYTIC ANTIBODY 1E9 (HEAVY CHAIN)","Mus musculus",5,"VAL H 171;VAL H 191;SER H 189;ASN H 209;ASN H 162","None","1.42A","2y03B-1c1eH:undetectable","2y03B-1c1eH:18.94"],["4G19_D_ACTD305_0","GLUTATHIONE TRANSFERASE GTE1","1c1e","CATALYTIC ANTIBODY 1E9 (HEAVY CHAIN)","Mus musculus",4,"ILE H  82;LEU H  80;LYS H  19;ASN H  82","None","1.36A","4g19D-1c1eH:0.0","4g19D-1c1eH:22.93"],["4LDO_A_ALEA1402_1","LYSOZYME, BETA-2 ADRENERGIC RECEPTOR","1c1e","CATALYTIC ANTIBODY 1E9 (HEAVY CHAIN)","Mus musculus",5,"VAL H 171;VAL H 191;SER H 189;ASN H 209;ASN H 162","None","1.46A","4ldoA-1c1eH:0.0","4ldoA-1c1eH:20.04"],["4LMN_A_EUIA503_2","DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1","1c1e","CATALYTIC ANTIBODY 1E9 (HEAVY CHAIN)","Mus musculus",3,"ASP H 183;VAL H 177;ASN H  84","None","0.76A","4lmnA-1c1eH:0.0","4lmnA-1c1eH:22.09"],["5XIW_D_LOCD503_1","TUBULIN ALPHA-1B CHAIN;TUBULIN BETA CHAIN","1c1e","CATALYTIC ANTIBODY 1E9 (HEAVY CHAIN)","Mus musculus",3,"SER H 216;ALA H 211;VAL H 210","None","0.51A","5xiwC-1c1eH:undetectable","5xiwC-1c1eH:14.93"]]