SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c25'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 1c25 CDC25A
(Homo
sapiens) 		4 / 6 LEU A 411
PHE A 410
ILE A 382
CYH A 384
 None
 0.93A 3ko0B-1c25A:
undetectable		 3ko0B-1c25A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 1c25 CDC25A
(Homo
sapiens) 		4 / 6 LEU A 411
PHE A 410
ILE A 382
CYH A 384
 None
 0.84A 3ko0S-1c25A:
undetectable		 3ko0S-1c25A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_A_FUNA201_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1c25 CDC25A
(Homo
sapiens) 		5 / 11 PRO A 361
SER A 360
ILE A 359
VAL A 427
ILE A 395
 None
 1.31A 3rf4A-1c25A:
0.7
3rf4C-1c25A:
0.7		 3rf4A-1c25A:
18.01
3rf4C-1c25A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_B_FUNB202_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1c25 CDC25A
(Homo
sapiens) 		5 / 11 ILE A 395
PRO A 361
SER A 360
ILE A 359
VAL A 427
 None
 1.35A 3rf4A-1c25A:
0.7
3rf4B-1c25A:
0.7		 3rf4A-1c25A:
18.01
3rf4B-1c25A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1c25 CDC25A
(Homo
sapiens) 		5 / 11 ILE A 395
PRO A 361
SER A 360
ILE A 359
VAL A 427
 None
 1.33A 3rf4B-1c25A:
0.7
3rf4C-1c25A:
0.7		 3rf4B-1c25A:
18.01
3rf4C-1c25A:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TVX_B_PNXB902_1
(CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4A)		 1c25 CDC25A
(Homo
sapiens) 		4 / 7 TYR A 463
ILE A 425
PHE A 379
PHE A 372
 None
 1.13A 3tvxB-1c25A:
undetectable		 3tvxB-1c25A:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1476_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1c25 CDC25A
(Homo
sapiens) 		4 / 5 ILE A 382
ALA A 398
HIS A 402
ARG A 385
 None
 1.31A 4acaB-1c25A:
2.0
4acaC-1c25A:
undetectable		 4acaB-1c25A:
18.56
4acaC-1c25A:
18.56