SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c2r'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_A_IMNA379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1c2r CYTOCHROME C2
(Rhodobacter
capsulatus) 		5 / 12 PRO A  79
PRO A  35
SER A  56
ILE A  57
LEU A  87
 None
HEM  A 120 (-4.8A)
None
HEM  A 120 (-4.2A)
None
 1.21A 1z9hA-1c2rA:
undetectable		 1z9hA-1c2rA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_B_IMNB381_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1c2r CYTOCHROME C2
(Rhodobacter
capsulatus) 		5 / 12 PRO A  79
PRO A  35
SER A  56
ILE A  57
LEU A  87
 None
HEM  A 120 (-4.8A)
None
HEM  A 120 (-4.2A)
None
 1.21A 1z9hB-1c2rA:
undetectable		 1z9hB-1c2rA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_C_IMNC379_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1c2r CYTOCHROME C2
(Rhodobacter
capsulatus) 		5 / 12 PRO A  79
PRO A  35
SER A  56
ILE A  57
LEU A  87
 None
HEM  A 120 (-4.8A)
None
HEM  A 120 (-4.2A)
None
 1.21A 1z9hC-1c2rA:
undetectable		 1z9hC-1c2rA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 1c2r CYTOCHROME C2
(Rhodobacter
capsulatus) 		5 / 12 PRO A  79
PRO A  35
SER A  56
ILE A  57
LEU A  87
 None
HEM  A 120 (-4.8A)
None
HEM  A 120 (-4.2A)
None
 1.22A 1z9hD-1c2rA:
undetectable		 1z9hD-1c2rA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_C_VIVC301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1c2r CYTOCHROME C2
(Rhodobacter
capsulatus) 		5 / 12 ILE A  57
LEU A 100
ILE A  72
VAL A 107
LEU A 111
 HEM  A 120 (-4.2A)
HEM  A 120 ( 4.2A)
HEM  A 120 ( 4.7A)
None
None
 1.06A 3w68C-1c2rA:
undetectable		 3w68C-1c2rA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 1c2r CYTOCHROME C2
(Rhodobacter
capsulatus) 		4 / 4 VAL A  41
THR A  68
GLU A  69
GLU A  70
 None
 1.12A 4l78A-1c2rA:
undetectable		 4l78A-1c2rA:
7.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1c2r CYTOCHROME C2
(Rhodobacter
capsulatus) 		4 / 6 LYS A   1
GLU A 105
GLY A 104
GLY A 103
 None
 1.05A 5a06D-1c2rA:
undetectable		 5a06D-1c2rA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJB_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1c2r CYTOCHROME C2
(Rhodobacter
capsulatus) 		5 / 12 TYR A  75
LEU A  87
ALA A  92
TYR A  53
ILE A  57
 HEM  A 120 (-4.6A)
None
None
HEM  A 120 (-4.7A)
HEM  A 120 (-4.2A)
 1.23A 5ljbA-1c2rA:
undetectable		 5ljbA-1c2rA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJC_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 1)		 1c2r CYTOCHROME C2
(Rhodobacter
capsulatus) 		5 / 12 TYR A  75
LEU A  87
ALA A  92
TYR A  53
ILE A  57
 HEM  A 120 (-4.6A)
None
None
HEM  A 120 (-4.7A)
HEM  A 120 (-4.2A)
 1.23A 5ljcA-1c2rA:
undetectable		 5ljcA-1c2rA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUG_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1c2r CYTOCHROME C2
(Rhodobacter
capsulatus) 		5 / 12 ILE A  57
LEU A 100
ILE A  72
VAL A 107
LEU A 111
 HEM  A 120 (-4.2A)
HEM  A 120 ( 4.2A)
HEM  A 120 ( 4.7A)
None
None
 1.03A 5mugA-1c2rA:
undetectable		 5mugA-1c2rA:
19.74