SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c2y'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T7J_A_478A200_1
(POL POLYPROTEIN)		 1c2y PROTEIN (LUMAZINE
SYNTHASE)
(Spinacia
oleracea) 		6 / 11 LEU A  78
ALA A  17
ASP A  49
VAL A  51
GLY A  67
VAL A  19
 None
 1.49A 1t7jA-1c2yA:
undetectable		 1t7jA-1c2yA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL5_B_1UNB201_2
(PROTEASE)		 1c2y PROTEIN (LUMAZINE
SYNTHASE)
(Spinacia
oleracea) 		6 / 12 ALA A  17
ASP A  49
VAL A  51
GLY A  67
THR A  62
VAL A  19
 None
 1.24A 3el5B-1c2yA:
undetectable		 3el5B-1c2yA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_1
(PROTEIN S100-A4)		 1c2y PROTEIN (LUMAZINE
SYNTHASE)
(Spinacia
oleracea) 		3 / 3 GLU A  33
LEU A  36
ASP A  37
 None
 0.42A 3ko0A-1c2yA:
undetectable		 3ko0A-1c2yA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 1c2y PROTEIN (LUMAZINE
SYNTHASE)
(Spinacia
oleracea) 		3 / 3 GLU A  33
LEU A  36
ASP A  37
 None
 0.32A 3ko0T-1c2yA:
undetectable		 3ko0T-1c2yA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1c2y PROTEIN (LUMAZINE
SYNTHASE)
(Spinacia
oleracea) 		3 / 3 VAL A  76
SER A 139
LEU A  78
 None
 0.70A 3n8xA-1c2yA:
undetectable		 3n8xA-1c2yA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_A_NPSA602_1
(SERUM ALBUMIN)		 1c2y PROTEIN (LUMAZINE
SYNTHASE)
(Spinacia
oleracea) 		5 / 9 ALA A  56
ALA A  21
LEU A  31
SER A  97
VAL A 100
 LMZ  A 201 (-3.1A)
LMZ  A 201 ( 3.8A)
None
None
None
 1.28A 4or0A-1c2yA:
undetectable		 4or0A-1c2yA:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYF_A_SAMA401_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7)		 1c2y PROTEIN (LUMAZINE
SYNTHASE)
(Spinacia
oleracea) 		5 / 11 ALA A 137
GLY A  34
GLU A  33
GLY A  79
ASN A 134
 None
None
None
LMZ  A 201 ( 4.9A)
None
 1.17A 5ayfA-1c2yA:
undetectable		 5ayfA-1c2yA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1c2y PROTEIN (LUMAZINE
SYNTHASE)
(Spinacia
oleracea) 		4 / 6 ALA A  74
VAL A  76
VAL A  44
HIS A  73
 None
 0.97A 5eckA-1c2yA:
undetectable		 5eckA-1c2yA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1c2y PROTEIN (LUMAZINE
SYNTHASE)
(Spinacia
oleracea) 		4 / 6 ALA A  74
VAL A  76
VAL A  44
HIS A  73
 None
 0.93A 5eckD-1c2yA:
undetectable		 5eckD-1c2yA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1c2y PROTEIN (LUMAZINE
SYNTHASE)
(Spinacia
oleracea) 		4 / 7 GLY A  67
VAL A  51
ILE A  18
VAL A  19
 None
 0.72A 5ik1A-1c2yA:
undetectable		 5ik1A-1c2yA:
16.54