SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c30'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CRB_A_RTLA200_0
(CELLULAR RETINOL
BINDING PROTEIN)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 12 LEU A 399
LEU A 402
ALA A 406
ILE A 424
ILE A 436
 None
 1.04A 1crbA-1c30A:
undetectable		 1crbA-1c30A:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 ASP A 128
ASP A 121
ASP A 133
 None
None
K  A4019 ( 4.6A)
 0.74A 1eizA-1c30A:
4.9		 1eizA-1c30A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 ASP A 128
ASP A 121
ASP A 133
 None
None
K  A4019 ( 4.6A)
 0.77A 1ej0A-1c30A:
4.7		 1ej0A-1c30A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM4_A_DXCA1001_0
(MAJOR POLLEN
ALLERGEN BET V 1-L)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 12 PRO A 345
PHE A 348
PRO A 350
THR A 315
ILE A 230
 None
 1.39A 1fm4A-1c30A:
0.7		 1fm4A-1c30A:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FO4_B_SALB4005_1
(XANTHINE
DEHYDROGENASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 7 GLU A 577
SER A 913
VAL A 893
ALA A  52
 None
None
ORN  A4010 ( 4.7A)
None
 1.06A 1fo4B-1c30A:
1.8		 1fo4B-1c30A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_J_TRPJ81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 ALA A 498
GLY A 405
ALA A 500
THR A 622
 None
 0.73A 1gtnI-1c30A:
0.7
1gtnJ-1c30A:
0.0		 1gtnI-1c30A:
5.50
1gtnJ-1c30A:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 GLU A 217
GLU A 383
ALA A 314
THR A 315
 K  A4017 (-3.6A)
None
None
None
 0.91A 1ie4B-1c30A:
1.3
1ie4D-1c30A:
1.0		 1ie4B-1c30A:
9.24
1ie4D-1c30A:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 LEU A 623
VAL A 626
VAL A 661
VAL A 638
 None
 0.93A 1iwiA-1c30A:
0.0		 1iwiA-1c30A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JTX_A_CVIA200_0
(HYPOTHETICAL
TRANSCRIPTIONAL
REGULATOR IN QACA
5'REGION)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 12 THR A1016
ILE A1001
ILE A1005
ILE A 986
ALA A 961
 None
 1.15A 1jtxA-1c30A:
undetectable		 1jtxA-1c30A:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_A_SAMA293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 ARG A 590
ASP A  57
ASN A  48
 None
 0.92A 1nbhA-1c30A:
4.0		 1nbhA-1c30A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_SAMD3293_1
(GLYCINE
N-METHYLTRANSFERASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 ARG A 590
ASP A  57
ASN A  48
 None
 0.88A 1nbhD-1c30A:
2.1		 1nbhD-1c30A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 PRO A 318
SER A 347
PHE A 348
ASP A 338
 None
 1.12A 1p7lC-1c30A:
undetectable		 1p7lC-1c30A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 PRO A 318
SER A 347
PHE A 348
ASP A 338
 None
 1.11A 1p7lD-1c30A:
undetectable		 1p7lD-1c30A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 PRO A 318
SER A 347
PHE A 348
ASP A 338
 None
 1.12A 1rg9A-1c30A:
undetectable		 1rg9A-1c30A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 PRO A 318
SER A 347
PHE A 348
ASP A 338
 None
 1.11A 1rg9B-1c30A:
undetectable		 1rg9B-1c30A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 PRO A 318
SER A 347
PHE A 348
ASP A 338
 None
 1.12A 1rg9C-1c30A:
undetectable		 1rg9C-1c30A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 PRO A 318
SER A 347
PHE A 348
ASP A 338
 None
 1.11A 1rg9D-1c30A:
undetectable		 1rg9D-1c30A:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_2
(POL POLYPROTEIN)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 10 GLY A  14
ILE A  45
ILE A  77
ILE A  66
ALA A  61
 None
 0.92A 1sh9B-1c30A:
undetectable		 1sh9B-1c30A:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 11 ASP A 763
THR A 849
HIS A 781
VAL A 787
SER A 913
 None
None
K  A4009 (-3.9A)
K  A4009 ( 4.4A)
None
 1.42A 1uofA-1c30A:
undetectable		 1uofA-1c30A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_L_TRPL81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 12 ALA A 585
THR A 596
ILE A 639
GLY A 593
ALA A 588
 None
 0.95A 1utdL-1c30A:
0.3
1utdM-1c30A:
0.7		 1utdL-1c30A:
5.50
1utdM-1c30A:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_O_TRPO81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 12 ALA A 585
THR A 596
ILE A 639
GLY A 593
ALA A 588
 None
 0.96A 1utdO-1c30A:
0.0
1utdP-1c30A:
0.7		 1utdO-1c30A:
5.50
1utdP-1c30A:
5.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 12 GLY A1046
GLY A1047
SER A 948
LEU A 960
HIS A1039
 None
 1.04A 1ya4C-1c30A:
2.8		 1ya4C-1c30A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 8 GLY A 281
GLY A 280
ALA A 323
LEU A 272
ILE A 229
 None
 1.05A 1yajC-1c30A:
3.2		 1yajC-1c30A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 8 GLY A1046
GLY A1047
ALA A1049
LEU A 964
HIS A1039
 None
 1.00A 1yajC-1c30A:
3.2		 1yajC-1c30A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_1
(GAG-POL POLYPROTEIN)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 12 GLY A  14
ILE A  45
ILE A  77
ILE A  66
ALA A  61
 None
 0.88A 2b60A-1c30A:
undetectable		 2b60A-1c30A:
7.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 12 MET A 240
ALA A 239
SER A 247
ASN A 236
GLY A 212
 ADP  A4000 (-4.0A)
None
K  A4003 (-2.7A)
K  A4003 (-3.9A)
None
 1.42A 2dcfA-1c30A:
0.0		 2dcfA-1c30A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_C_ACTC1120_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 LYS A 321
TYR A 610
PRO A 318
 None
 1.18A 2j9cC-1c30A:
0.0		 2j9cC-1c30A:
7.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 PRO A 318
SER A 347
PHE A 348
ASP A 338
 None
 1.06A 2obvA-1c30A:
undetectable		 2obvA-1c30A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q72_A_IXXA802_1
(TRANSPORTER)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 6 ILE A 359
ARG A 435
ILE A 439
PHE A 409
 None
 0.87A 2q72A-1c30A:
0.0		 2q72A-1c30A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 6 LEU A 906
ASP A 904
ILE A1023
ARG A1027
 None
 1.00A 2rlfC-1c30A:
0.0
2rlfD-1c30A:
0.0		 2rlfC-1c30A:
3.88
2rlfD-1c30A:
3.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XTK_B_AZMB1339_1
(CLASS III CHITINASE
CHIA1)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 10 TYR A1012
GLY A1046
ALA A1049
ASP A1041
GLN A 932
 None
None
None
ORN  A4010 (-4.6A)
None
 1.47A 2xtkB-1c30A:
undetectable		 2xtkB-1c30A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGQ_A_PCFA1275_0
(WNT INHIBITORY
FACTOR 1)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 12 ILE A 439
ILE A 359
PRO A 360
PHE A 409
PHE A 497
 None
 0.97A 2ygqA-1c30A:
0.0		 2ygqA-1c30A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 6 LEU A 623
VAL A 626
VAL A 661
VAL A 638
 None
 0.79A 2z97A-1c30A:
0.0		 2z97A-1c30A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZMA_A_ACAA502_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 11 MET A 240
ALA A 239
SER A 247
ASN A 236
GLY A 212
 ADP  A4000 (-4.0A)
None
K  A4003 (-2.7A)
K  A4003 (-3.9A)
None
 1.42A 2zmaA-1c30A:
0.0		 2zmaA-1c30A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 LEU A 623
VAL A 626
VAL A 661
VAL A 638
 None
 0.86A 2zujA-1c30A:
0.0		 2zujA-1c30A:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AOD_C_RFPC2002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 12 PHE A  26
ALA A  23
THR A  53
ASN A 570
GLY A 575
 None
 1.45A 3aodC-1c30A:
0.0		 3aodC-1c30A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_E_SVRE510_2
(PHOSPHOLIPASE A2)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 6 VAL A 464
GLY A 496
ARG A 501
LEU A 502
 None
 1.06A 3bjwE-1c30A:
undetectable		 3bjwE-1c30A:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_B_SAMB300_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 5 LYS A 527
ASP A 353
GLU A 548
GLU A 552
 None
 1.39A 3dh0B-1c30A:
3.5		 3dh0B-1c30A:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 ASP A 128
ASP A 121
ASP A 133
 None
None
K  A4019 ( 4.6A)
 0.79A 3douA-1c30A:
3.6		 3douA-1c30A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JQZ_A_LQZA586_1
(SERUM ALBUMIN)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 6 ARG A 273
ARG A 222
ASP A 223
ARG A 265
 None
 1.43A 3jqzA-1c30A:
0.1		 3jqzA-1c30A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 ASN A  50
ASP A  27
ARG A 845
 None
 0.83A 3k13C-1c30A:
0.6		 3k13C-1c30A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 ARG A1004
VAL A 949
THR A 977
 None
 0.87A 3k4vA-1c30A:
undetectable		 3k4vA-1c30A:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 6 HIS A1069
VAL A 879
SER A 854
LEU A 774
 None
 0.83A 3kk6A-1c30A:
0.0		 3kk6A-1c30A:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 8 LEU A 335
LEU A 326
ILE A 319
VAL A 221
LEU A 332
 None
 1.37A 3kp6A-1c30A:
0.8
3kp6B-1c30A:
0.0		 3kp6A-1c30A:
9.86
3kp6B-1c30A:
9.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MBG_A_ACTA207_0
(FAD-LINKED
SULFHYDRYL OXIDASE
ALR)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 7 LEU A 502
ARG A 501
THR A 407
ALA A 498
 None
 1.23A 3mbgA-1c30A:
0.0
3mbgB-1c30A:
0.0		 3mbgA-1c30A:
8.29
3mbgB-1c30A:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_A_URFA521_1
(RNA DEPENDENT RNA
POLYMERASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 5 ARG A 845
ASP A 765
ASP A 763
ARG A 848
 None
 1.11A 3naiA-1c30A:
2.0		 3naiA-1c30A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NAI_C_URFC521_1
(RNA DEPENDENT RNA
POLYMERASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 5 ARG A 845
ASP A 765
ASP A 763
ARG A 848
 None
 1.26A 3naiC-1c30A:
1.3		 3naiC-1c30A:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 6 GLU A 403
PRO A 360
ARG A 361
GLY A 568
 None
 1.18A 3oxvA-1c30A:
undetectable		 3oxvA-1c30A:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QEL_B_QELB1_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
EPSILON-2)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 11 TYR A 261
THR A 257
ILE A 263
THR A 244
GLU A 215
 None
None
None
K  A4017 ( 3.5A)
ADP  A4000 ( 2.8A)
 1.26A 3qelA-1c30A:
4.1
3qelB-1c30A:
4.1		 3qelA-1c30A:
18.12
3qelB-1c30A:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QJ7_A_SPMA264_1
(THYMIDYLATE SYNTHASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 ALA A 445
LEU A 421
ASP A 416
SER A 414
 None
 0.84A 3qj7A-1c30A:
0.0
3qj7D-1c30A:
0.0		 3qj7A-1c30A:
13.71
3qj7D-1c30A:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 6 ALA A 155
ILE A 206
LEU A 204
GLU A 189
ALA A 193
 None
 1.50A 3r9sA-1c30A:
undetectable		 3r9sA-1c30A:
14.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SG9_B_KANB305_1
(APH(2'')-ID)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 ASN A 843
ASP A 763
HIS A 781
GLU A 916
 K  A4008 (-3.3A)
None
K  A4009 (-3.9A)
None
 1.13A 3sg9B-1c30A:
1.5		 3sg9B-1c30A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 12 MET A 240
ALA A 239
SER A 247
ASN A 236
GLY A 212
 ADP  A4000 (-4.0A)
None
K  A4003 (-2.7A)
K  A4003 (-3.9A)
None
 1.41A 3vwqA-1c30A:
0.0		 3vwqA-1c30A:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 ARG A1030
ARG A1020
ASP A1025
 None
 0.91A 3wipG-1c30A:
0.0
3wipH-1c30A:
0.0		 3wipG-1c30A:
12.02
3wipH-1c30A:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 5 PHE A 928
ILE A 782
GLY A1046
THR A1050
 None
 0.70A 4ejjC-1c30A:
0.0		 4ejjC-1c30A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGL_C_CLQC303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 GLY A 908
VAL A 787
HIS A 788
PHE A 367
 None
K  A4009 ( 4.4A)
ADP  A4006 (-4.2A)
None
 0.97A 4fglD-1c30A:
3.4		 4fglD-1c30A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 ASP A 614
ARG A 590
ASP A 558
 None
 0.77A 4fp9A-1c30A:
2.2		 4fp9A-1c30A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_1
(METHYLTRANSFERASE
NSUN4)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 ASP A 614
ARG A 590
ASP A 558
 None
 0.78A 4fp9C-1c30A:
2.2		 4fp9C-1c30A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_1
(METHYLTRANSFERASE
NSUN4)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 ASP A 614
ARG A 590
ASP A 558
 None
 0.83A 4fp9F-1c30A:
2.2		 4fp9F-1c30A:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 7 ALA A 657
GLU A 510
LEU A 623
LEU A 627
 None
 1.03A 4iomA-1c30A:
2.8		 4iomA-1c30A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 11 GLU A 299
ASN A 301
SER A 305
ILE A 319
LEU A 326
 MN  A4001 (-2.0A)
MN  A4001 (-2.4A)
None
None
None
 1.45A 4k37B-1c30A:
undetectable		 4k37B-1c30A:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 PRO A 318
SER A 347
PHE A 348
ASP A 338
 None
 1.07A 4kttA-1c30A:
undetectable		 4kttA-1c30A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 PRO A 318
SER A 347
PHE A 348
ASP A 338
 None
 1.02A 4kttC-1c30A:
undetectable		 4kttC-1c30A:
17.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4B_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 LEU A 623
VAL A 626
VAL A 661
VAL A 638
 None
 0.93A 4l4bA-1c30A:
0.0		 4l4bA-1c30A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 12 PRO A  17
PHE A  26
VAL A  19
GLY A 245
MET A 174
 None
None
None
None
PO4  A4005 (-4.1A)
 1.33A 4mubA-1c30A:
undetectable		 4mubA-1c30A:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA901_0
(PROTEIN ARGONAUTE-2)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 VAL A 957
ALA A 962
PHE A1048
 None
 0.91A 4olbA-1c30A:
3.7		 4olbA-1c30A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_A_SAMA301_0
(PUTATIVE RNA
METHYLASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 12 THR A1043
GLY A1047
ASN A1045
LEU A 960
SER A1018
 ORN  A4010 ( 4.9A)
None
None
None
None
 1.36A 4pooA-1c30A:
3.5		 4pooA-1c30A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 ALA A1053
ILE A1014
GLY A1046
SER A 935
 None
 0.80A 4r20A-1c30A:
0.0		 4r20A-1c30A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 VAL A 957
ALA A 962
PHE A1048
 None
 0.91A 4w5nA-1c30A:
2.2		 4w5nA-1c30A:
22.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YJI_A_TYLA502_1
(ARYL ACYLAMIDASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 7 LEU A  87
GLY A 280
GLY A 281
ILE A 319
 None
 0.64A 4yjiA-1c30A:
0.0		 4yjiA-1c30A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_F_TR6F101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 5 GLY A  21
ARG A 306
GLY A 382
GLU A 383
 None
PO4  A4005 (-2.8A)
None
None
 1.27A 4z2eB-1c30A:
0.0
4z2eC-1c30A:
2.4		 4z2eB-1c30A:
19.61
4z2eC-1c30A:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 7 PHE A 928
GLY A1046
THR A1043
LEU A 907
 None
None
ORN  A4010 ( 4.9A)
ORN  A4010 (-4.0A)
 0.91A 4zdzA-1c30A:
0.0		 4zdzA-1c30A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 7 PHE A 928
GLY A1046
THR A1043
LEU A 907
 None
None
ORN  A4010 ( 4.9A)
ORN  A4010 (-4.0A)
 0.85A 4ze3A-1c30A:
0.0		 4ze3A-1c30A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_A_SORA1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 7 ILE A 181
CYH A 166
GLY A 179
GLY A 180
 None
 0.82A 5a06A-1c30A:
2.1		 5a06A-1c30A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_B_SORB1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 7 ILE A 181
CYH A 166
GLY A 179
GLY A 180
 None
 0.83A 5a06B-1c30A:
2.1		 5a06B-1c30A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_C_SORC1342_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 7 ILE A 181
CYH A 166
GLY A 179
GLY A 180
 None
 0.82A 5a06C-1c30A:
4.7		 5a06C-1c30A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_E_SORE1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 7 ILE A 181
CYH A 166
GLY A 179
GLY A 180
 None
 0.83A 5a06E-1c30A:
0.2		 5a06E-1c30A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_F_SORF1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 7 ILE A 181
CYH A 166
GLY A 179
GLY A 180
 None
 0.81A 5a06F-1c30A:
5.2		 5a06F-1c30A:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 ASN A  50
LEU A  46
PHE A  26
 None
 0.72A 5dsgA-1c30A:
0.0		 5dsgA-1c30A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		6 / 12 ILE A 352
PHE A 536
GLY A 316
ILE A 339
THR A 340
ASP A 530
 None
 1.38A 5e72A-1c30A:
4.5		 5e72A-1c30A:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 12 GLY A 573
GLY A 643
GLY A 567
GLY A 575
GLU A 403
 None
 0.90A 5ehgC-1c30A:
undetectable		 5ehgC-1c30A:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 PHE A 928
GLY A1046
THR A1043
LEU A 907
 None
None
ORN  A4010 ( 4.9A)
ORN  A4010 (-4.0A)
 0.89A 5eseA-1c30A:
0.0		 5eseA-1c30A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 PHE A 928
GLY A1046
THR A1043
LEU A 907
 None
None
ORN  A4010 ( 4.9A)
ORN  A4010 (-4.0A)
 0.91A 5esfA-1c30A:
0.0		 5esfA-1c30A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 PHE A 928
GLY A1046
THR A1043
LEU A 907
 None
None
ORN  A4010 ( 4.9A)
ORN  A4010 (-4.0A)
 0.86A 5esjA-1c30A:
0.0		 5esjA-1c30A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 7 PHE A 928
GLY A1046
THR A1043
LEU A 907
 None
None
ORN  A4010 ( 4.9A)
ORN  A4010 (-4.0A)
 0.92A 5esmA-1c30A:
0.0		 5esmA-1c30A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 12 GLY A  21
GLY A 176
SER A 177
GLY A 382
SER A 380
 None
ADP  A4000 (-3.2A)
CL  A4012 ( 4.1A)
None
None
 1.03A 5gwxA-1c30A:
4.0		 5gwxA-1c30A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIK_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 12 GLY A  21
GLY A 176
SER A 177
GLY A 382
SER A 380
 None
ADP  A4000 (-3.2A)
CL  A4012 ( 4.1A)
None
None
 1.03A 5hikA-1c30A:
3.5		 5hikA-1c30A:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGU_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 VAL A 764
VAL A 828
GLN A 812
 None
 0.69A 5qguA-1c30A:
0.0		 5qguA-1c30A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGV_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 VAL A 764
VAL A 828
GLN A 812
 None
 0.71A 5qgvA-1c30A:
0.0		 5qgvA-1c30A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGW_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 VAL A 764
VAL A 828
GLN A 812
 None
 0.69A 5qgwA-1c30A:
0.0		 5qgwA-1c30A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGX_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 VAL A 764
VAL A 828
GLN A 812
 None
 0.70A 5qgxA-1c30A:
0.0		 5qgxA-1c30A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH1_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 VAL A 764
VAL A 828
GLN A 812
 None
 0.71A 5qh1A-1c30A:
0.0		 5qh1A-1c30A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QH9_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 VAL A 764
VAL A 828
GLN A 812
 None
 0.68A 5qh9A-1c30A:
0.0		 5qh9A-1c30A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHA_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 VAL A 764
VAL A 828
GLN A 812
 None
 0.67A 5qhaA-1c30A:
0.0		 5qhaA-1c30A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHE_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 VAL A 764
VAL A 828
GLN A 812
 None
 0.69A 5qheA-1c30A:
0.0		 5qheA-1c30A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QHF_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 VAL A 764
VAL A 828
GLN A 812
 None
 0.69A 5qhfA-1c30A:
0.0		 5qhfA-1c30A:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 GLY A  91
GLN A  93
LEU A  96
THR A  94
 None
None
None
NET  A4011 (-4.1A)
 0.99A 5syjB-1c30A:
0.0		 5syjB-1c30A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYJ_B_NIZB809_1
(CATALASE-PEROXIDASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 GLY A 643
GLN A 645
LEU A 648
THR A 646
 None
 0.96A 5syjB-1c30A:
0.0		 5syjB-1c30A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 6 PHE A  26
PRO A  17
ALA A  23
THR A 914
 None
 1.13A 5t7bA-1c30A:
0.0		 5t7bA-1c30A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_A_08JA602_1
(CYTOCHROME P450 3A4)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 7 ARG A 501
ALA A 477
ILE A 481
LEU A 484
 None
 0.91A 5te8A-1c30A:
0.0		 5te8A-1c30A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 HIS A1039
LEU A1054
THR A1050
ALA A1053
 None
 0.94A 5tt3H-1c30A:
undetectable		 5tt3H-1c30A:
12.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_0
(METHYLTRANSFERASE)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		5 / 12 GLY A 573
GLY A 643
GLY A 567
GLY A 575
GLU A 403
 None
 0.93A 5vimA-1c30A:
undetectable		 5vimA-1c30A:
14.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZV2_A_LEVA801_2
(FIBROBLAST GROWTH
FACTOR RECEPTOR 1)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		3 / 3 LYS A  76
LEU A 933
ASP A1057
 None
 0.53A 5zv2A-1c30A:
undetectable		 5zv2A-1c30A:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 LEU A 623
VAL A 626
VAL A 661
VAL A 638
 None
 0.93A 6cp4A-1c30A:
0.0		 6cp4A-1c30A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 5 THR A 173
THR A 244
GLN A 285
ASP A 238
 CL  A4012 (-4.5A)
K  A4017 ( 3.5A)
MN  A4002 ( 2.5A)
None
 1.43A 6ecxA-1c30A:
3.0		 6ecxA-1c30A:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 PRO A 318
SER A 347
PHE A 348
ASP A 338
 None
 1.11A 6fcbA-1c30A:
undetectable		 6fcbA-1c30A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1c30 CARBAMOYL PHOSPHATE
SYNTHETASE: LARGE
SUBUNIT
(Escherichia
coli) 		4 / 8 PRO A 318
SER A 347
PHE A 348
ASP A 338
 None
 1.08A 6fcdA-1c30A:
undetectable		 6fcdA-1c30A:
5.82