SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c39'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 1c39 CATION-DEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Bos
taurus) 		3 / 3 LEU A  26
LEU A 124
MET A 147
 None
 0.78A 1ya3B-1c39A:
undetectable		 1ya3B-1c39A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA4_B_ACHB603_0
(ACETYLCHOLINESTERASE)		 1c39 CATION-DEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Bos
taurus) 		4 / 7 TYR A  45
TYR A 102
HIS A 105
GLY A 136
 P3M  A1200 (-4.5A)
P3M  A1200 (-4.8A)
P3M  A1200 (-3.7A)
None
 1.19A 2ha4B-1c39A:
undetectable		 2ha4B-1c39A:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OCT_A_1N1A663_2
(TYROSINE-PROTEIN
KINASE BTK)		 1c39 CATION-DEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Bos
taurus) 		4 / 5 ILE A  95
MET A 147
ASN A 127
PHE A  86
 None
 1.28A 3octA-1c39A:
undetectable		 3octA-1c39A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA270_0
(PROTEIN SSM1)		 1c39 CATION-DEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Bos
taurus) 		4 / 5 LEU A 124
SER A 149
LEU A  29
PRO A  28
 None
 0.99A 3onnA-1c39A:
0.0		 3onnA-1c39A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 1c39 CATION-DEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Bos
taurus) 		3 / 3 ASP A 148
ASN A  90
PHE A 145
 None
 0.76A 5jglB-1c39A:
undetectable		 5jglB-1c39A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNK_B_NCTB402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1c39 CATION-DEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR
(Bos
taurus) 		4 / 7 CSS A   6
CSS A  52
TYR A  96
LEU A   8
 None
 1.29A 6cnkB-1c39A:
undetectable
6cnkC-1c39A:
undetectable		 6cnkB-1c39A:
19.87
6cnkC-1c39A:
21.17