SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c3c'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AL4_A_DVAA8_0
(GRAMICIDIN D)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		4 / 5 VAL A 154
TRP A 125
VAL A 123
TRP A 157
 None
 1.50A 1al4A-1c3cA:
undetectable
1al4B-1c3cA:
undetectable		 1al4A-1c3cA:
4.36
1al4B-1c3cA:
4.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWI_A_CAMA418_0
(CYTOCHROME P450-CAM)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		4 / 8 LEU A 124
VAL A 127
VAL A 251
VAL A 336
 None
 0.87A 1iwiA-1c3cA:
0.0		 1iwiA-1c3cA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KW0_A_H4BA429_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		5 / 12 VAL A  30
LEU A  92
SER A  94
LEU A  98
THR A  31
 None
 1.29A 1kw0A-1c3cA:
undetectable		 1kw0A-1c3cA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMT_A_H4BA1426_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		5 / 11 VAL A  30
LEU A  92
SER A  94
LEU A  98
THR A  31
 None
 1.27A 1mmtA-1c3cA:
undetectable		 1mmtA-1c3cA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T86_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		4 / 8 LEU A 124
VAL A 127
VAL A 251
VAL A 336
 None
 0.92A 1t86A-1c3cA:
0.0		 1t86A-1c3cA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		5 / 12 THR A  93
VAL A  70
ASP A  69
SER A 306
HIS A 305
 None
 1.09A 1xvaA-1c3cA:
undetectable		 1xvaA-1c3cA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AJV_L_COCL501_1
(ANTIBODY 7A1 FAB')		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		4 / 7 ALA A 237
ARG A 241
TYR A   5
TYR A 322
 None
 1.07A 2ajvH-1c3cA:
undetectable
2ajvL-1c3cA:
undetectable		 2ajvH-1c3cA:
19.16
2ajvL-1c3cA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		5 / 9 GLY A 178
GLU A 207
ILE A 180
ALA A 198
VAL A  30
 None
 1.36A 2drdA-1c3cA:
0.1		 2drdA-1c3cA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQD_A_AG2A671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		4 / 7 LEU A 117
LEU A 226
ILE A 228
MET A 161
 None
 1.03A 2qqdA-1c3cA:
0.0
2qqdE-1c3cA:
0.0		 2qqdA-1c3cA:
8.70
2qqdE-1c3cA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YA7_C_ZMRC1776_2
(NEURAMINIDASE A)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		4 / 6 ARG A  86
ASP A  84
ILE A  48
GLU A  35
 None
 1.36A 2ya7C-1c3cA:
undetectable		 2ya7C-1c3cA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		4 / 6 LEU A 124
VAL A 127
VAL A 251
VAL A 336
 None
 0.88A 2z97A-1c3cA:
0.0		 2z97A-1c3cA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		4 / 8 LEU A 124
VAL A 127
VAL A 251
VAL A 336
 None
 0.88A 2zujA-1c3cA:
0.0		 2zujA-1c3cA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F93_B_SANB3004_1
(U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		4 / 8 GLU A  27
GLU A 195
GLY A 182
SER A 181
 None
 0.86A 4f93B-1c3cA:
0.0		 4f93B-1c3cA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X3M_A_ADNA301_1
(RNA 2'-O RIBOSE
METHYLTRANSFERASE)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		5 / 9 LEU A 204
GLY A 203
GLU A  25
ILE A 180
THR A 100
 None
 1.45A 4x3mA-1c3cA:
undetectable		 4x3mA-1c3cA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		3 / 3 VAL A 123
THR A 328
ARG A 332
 None
 0.78A 5b2sB-1c3cA:
0.0		 5b2sB-1c3cA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		3 / 3 VAL A 123
THR A 328
ARG A 332
 None
 0.79A 5b2tB-1c3cA:
2.1		 5b2tB-1c3cA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSH_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		4 / 5 ARG A 139
LEU A 243
ASN A 344
VAL A 248
 None
 1.47A 5cshB-1c3cA:
undetectable		 5cshB-1c3cA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		5 / 12 GLY A 185
GLY A 178
LEU A 204
GLY A  91
VAL A 190
 None
 0.81A 5i71A-1c3cA:
undetectable		 5i71A-1c3cA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		5 / 12 GLY A 185
GLY A 178
LEU A 204
GLY A  91
VAL A 190
 None
 0.84A 5i73A-1c3cA:
undetectable		 5i73A-1c3cA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I75_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		5 / 12 GLY A 185
GLY A 178
LEU A 204
GLY A  91
VAL A 190
 None
 0.78A 5i75A-1c3cA:
0.1		 5i75A-1c3cA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		5 / 12 ILE A 180
LEU A  92
SER A 210
GLY A 178
ASP A  99
 None
 1.16A 5nnaA-1c3cA:
undetectable		 5nnaA-1c3cA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		5 / 12 ILE A 180
LEU A  92
SER A 210
GLY A 178
ASP A  99
 None
 1.19A 5nnaB-1c3cA:
undetectable		 5nnaB-1c3cA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		5 / 12 ILE A 180
LEU A  92
SER A 210
GLY A 178
ASP A  99
 None
 1.19A 5nnaC-1c3cA:
undetectable		 5nnaC-1c3cA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_D_BZMD301_0
(ISATIN HYDROLASE A)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		5 / 12 ILE A 180
LEU A  92
SER A 210
GLY A 178
ASP A  99
 None
 1.19A 5nnaD-1c3cA:
undetectable		 5nnaD-1c3cA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_2
(CYTOCHROME P450 2C9)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		3 / 3 LEU A 155
VAL A 421
ASP A 422
 None
 0.58A 5x23A-1c3cA:
0.0		 5x23A-1c3cA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		4 / 8 LEU A 124
VAL A 127
VAL A 251
VAL A 336
 None
 0.85A 6cp4A-1c3cA:
0.0		 6cp4A-1c3cA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7J_A_5FWA401_0
(BETA-1 ADRENERGIC
RECEPTOR)		 1c3c PROTEIN
(ADENYLOSUCCINATE
LYASE)
(Thermotoga
maritima) 		5 / 12 TRP A  14
THR A 317
VAL A 312
SER A 291
ASN A 102
 None
 1.45A 6h7jA-1c3cA:
3.5		 6h7jA-1c3cA:
13.70