SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c3e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OKC_A_SAMA500_0
(TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		5 / 12 ALA A  40
GLY A  87
THR A  53
VAL A  33
ASN A  10
 None
GAR  A 221 (-3.2A)
None
None
GAR  A 221 ( 4.7A)
 0.98A 2okcA-1c3eA:
2.6		 2okcA-1c3eA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XN5_A_FUNA1356_2
(THYROXINE-BINDING
GLOBULIN)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		3 / 3 LEU A   6
ARG A  90
ILE A   7
 None
 0.63A 2xn5B-1c3eA:
0.4		 2xn5B-1c3eA:
10.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCJ_A_THHA401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		5 / 12 MET A  89
ILE A  91
LEU A  92
ASN A 106
VAL A 139
 GAR  A 221 ( 4.3A)
NHR  A 220 (-4.3A)
NHR  A 220 (-3.9A)
NHR  A 220 (-3.0A)
NHR  A 220 (-4.5A)
 0.78A 3dcjA-1c3eA:
14.1
3dcjB-1c3eA:
28.4		 3dcjA-1c3eA:
32.89
3dcjB-1c3eA:
32.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		4 / 8 ILE A  91
LEU A  92
ASN A 106
VAL A 139
 NHR  A 220 (-4.3A)
NHR  A 220 (-3.9A)
NHR  A 220 (-3.0A)
NHR  A 220 (-4.5A)
 0.63A 3dcjB-1c3eA:
28.4		 3dcjB-1c3eA:
32.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		4 / 7 LEU A   6
LEU A  71
ASN A  36
ASP A  68
 None
 1.02A 3lm8A-1c3eA:
4.9
3lm8C-1c3eA:
5.7		 3lm8A-1c3eA:
24.81
3lm8C-1c3eA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_A_VIBA223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		4 / 7 TYR A 100
LEU A  85
LEU A  92
SER A  98
 None
NHR  A 220 ( 4.8A)
NHR  A 220 (-3.9A)
None
 1.03A 3lm8A-1c3eA:
4.9
3lm8C-1c3eA:
5.7		 3lm8A-1c3eA:
24.81
3lm8C-1c3eA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		4 / 8 ASP A  68
LEU A   6
LEU A  71
ASN A  36
 None
 0.90A 3lm8A-1c3eA:
4.9
3lm8C-1c3eA:
5.4		 3lm8A-1c3eA:
24.81
3lm8C-1c3eA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		4 / 8 ASP A  68
LEU A   6
LEU A  71
ASN A  36
 None
 1.03A 3lm8B-1c3eA:
5.2
3lm8D-1c3eA:
undetectable		 3lm8B-1c3eA:
24.81
3lm8D-1c3eA:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ0_X_DXCX75_0
(CYTOCHROME C7)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		4 / 7 ILE A 181
PHE A 138
MET A 191
GLY A 102
 None
 1.22A 3sj0X-1c3eA:
undetectable		 3sj0X-1c3eA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		4 / 7 ILE A 107
ASN A  13
GLU A 173
GLN A 123
 GAR  A 221 (-4.2A)
GAR  A 221 (-4.1A)
GAR  A 221 (-2.6A)
None
 1.08A 4g0vA-1c3eA:
2.0		 4g0vA-1c3eA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		3 / 3 PRO A  94
VAL A 139
HIS A 137
 None
NHR  A 220 (-4.5A)
None
 0.84A 4pevC-1c3eA:
2.4		 4pevC-1c3eA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C8T_B_SAMB605_0
(GUANINE-N7
METHYLTRANSFERASE)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		5 / 11 GLY A 207
PRO A 204
ALA A 196
PHE A 138
VAL A 180
 None
 1.28A 5c8tB-1c3eA:
3.0		 5c8tB-1c3eA:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		5 / 11 ILE A 181
LEU A 150
ALA A 175
VAL A  82
LEU A 189
 None
 1.17A 5ji0A-1c3eA:
undetectable		 5ji0A-1c3eA:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_B_DAHB60_1
(PUTATIVE CYTOCHROME
C)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		4 / 5 HIS A 137
ASN A  13
VAL A  84
LEU A 104
 None
GAR  A 221 (-4.1A)
None
None
 1.25A 5xdhB-1c3eA:
undetectable		 5xdhB-1c3eA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDH_D_DAHD60_1
(PUTATIVE CYTOCHROME
C)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		4 / 5 HIS A 137
ASN A  13
VAL A  84
LEU A 104
 None
GAR  A 221 (-4.1A)
None
None
 1.28A 5xdhD-1c3eA:
0.0		 5xdhD-1c3eA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRX_A_H8GA1201_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		5 / 12 LEU A 105
VAL A 136
SER A 135
THR A 134
ALA A 152
 None
 1.40A 6drxA-1c3eA:
undetectable		 6drxA-1c3eA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA717_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 1c3e GLYCINAMIDE
RIBONUCLEOTIDE
TRANSFORMYLASE
(Escherichia
coli) 		4 / 5 SER A  93
ARG A  64
ASP A  68
ARG A  90
 None
NHR  A 220 (-3.1A)
None
None
 1.17A 6dwdA-1c3eA:
0.0		 6dwdA-1c3eA:
16.33