SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c4o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA350_2
(PROTEIN (ADENOSINE
KINASE))		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		3 / 3 LEU A 342
SER A 140
ASN A  63
 None
 0.70A 1bx4A-1c4oA:
0.2		 1bx4A-1c4oA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSE_A_EAAA224_1
(GLUTATHIONE
TRANSFERASE)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		5 / 12 LEU A  25
LEU A  21
VAL A  49
ALA A  57
PHE A 331
 None
 1.27A 1gseA-1c4oA:
0.0		 1gseA-1c4oA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 5 LEU A 515
VAL A 445
ALA A 467
CYH A 493
 None
 0.92A 1mz9C-1c4oA:
0.0		 1mz9C-1c4oA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_A_SWFA502_1
(CYTOCHROME P450 2C9)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		5 / 12 PHE A 394
LEU A 396
LEU A 332
LEU A 378
PHE A  31
 None
BOG  A9998 ( 4.5A)
None
None
None
 1.22A 1og5A-1c4oA:
0.0		 1og5A-1c4oA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_E_FUAE706_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		5 / 10 THR A  33
SER A 399
PHE A 394
PHE A 374
VAL A 339
 None
 1.48A 1q23E-1c4oA:
1.1		 1q23E-1c4oA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		5 / 10 THR A  33
SER A 399
PHE A 394
PHE A 374
VAL A 339
 None
 1.44A 1q23K-1c4oA:
1.1		 1q23K-1c4oA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_D_TFPD207_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 8 SER A 399
LEU A  21
LEU A 342
SER A 388
 None
 0.85A 1wrlC-1c4oA:
undetectable
1wrlD-1c4oA:
undetectable		 1wrlC-1c4oA:
8.58
1wrlD-1c4oA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_2
(CES1 PROTEIN)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 4 LEU A  25
PRO A 325
ILE A  50
LEU A  53
 None
 1.02A 1ya4C-1c4oA:
undetectable		 1ya4C-1c4oA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		5 / 12 TYR A  90
SER A  88
VAL A  59
ALA A  71
ALA A  67
 None
 1.50A 2avdA-1c4oA:
undetectable		 2avdA-1c4oA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q63_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		3 / 3 ARG A 118
ASN A 155
THR A 124
 None
 0.72A 2q63A-1c4oA:
0.0		 2q63A-1c4oA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X7H_B_PFNB1374_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 4 TYR A 323
LEU A 321
LEU A 320
HIS A 244
 None
 1.17A 2x7hB-1c4oA:
3.2		 2x7hB-1c4oA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		5 / 12 VAL A 402
LEU A  34
THR A  33
THR A  38
THR A  40
 None
None
None
SO4  A9001 (-4.6A)
None
 1.22A 3a35B-1c4oA:
undetectable		 3a35B-1c4oA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 6 GLN A 383
PHE A  31
PHE A 386
LEU A 332
 None
 1.12A 3ablP-1c4oA:
undetectable
3ablW-1c4oA:
0.0		 3ablP-1c4oA:
16.59
3ablW-1c4oA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 7 LEU A  58
PHE A 324
LEU A 320
PHE A  86
 None
 1.05A 3asnP-1c4oA:
undetectable
3asnW-1c4oA:
0.0		 3asnP-1c4oA:
16.59
3asnW-1c4oA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASO_P_CHDP1271_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 7 LEU A  58
PHE A 324
LEU A 320
PHE A  86
 None
 1.05A 3asoP-1c4oA:
undetectable
3asoW-1c4oA:
0.0		 3asoP-1c4oA:
16.59
3asoW-1c4oA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 8 VAL A  44
GLY A  41
PRO A 409
LYS A  48
 None
SO4  A9001 (-3.5A)
None
None
 0.98A 3bjwA-1c4oA:
undetectable		 3bjwA-1c4oA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CV9_A_VDXA501_1
(CYTOCHROME P450-SU1)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		5 / 9 THR A 532
VAL A 509
ARG A 442
ILE A 433
ILE A 514
 None
 1.22A 3cv9A-1c4oA:
0.0		 3cv9A-1c4oA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		3 / 3 GLU A 526
SER A 552
VAL A 551
 BOG  A9998 (-3.7A)
None
None
 0.82A 3eeoA-1c4oA:
undetectable		 3eeoA-1c4oA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 4 ARG A 487
ASP A 414
GLY A 411
THR A 582
 None
 1.38A 3k4vB-1c4oA:
undetectable		 3k4vB-1c4oA:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		3 / 3 PHE A  86
TYR A 143
LEU A  70
 None
 0.71A 3keeB-1c4oA:
0.0		 3keeB-1c4oA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		3 / 3 PHE A  86
TYR A 143
LEU A  70
 None
 0.67A 3sueB-1c4oA:
undetectable		 3sueB-1c4oA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD2_1
(CYTOCHROME P450 2D6)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		5 / 9 PHE A 377
LEU A  60
LEU A 321
ILE A 142
PHE A 324
 None
 0.99A 3tbgD-1c4oA:
0.0		 3tbgD-1c4oA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_I_CLMI221_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		5 / 10 THR A  33
SER A 399
PHE A 394
PHE A 374
VAL A 339
 None
 1.49A 3u9fI-1c4oA:
0.9		 3u9fI-1c4oA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_J_CLMJ221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		5 / 12 THR A  33
SER A 399
PHE A 394
PHE A 374
VAL A 339
 None
 1.40A 3u9fJ-1c4oA:
0.5
3u9fK-1c4oA:
1.5		 3u9fJ-1c4oA:
14.57
3u9fK-1c4oA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 6 LEU A  58
PHE A 324
LEU A 320
PHE A  86
 None
 1.07A 3wg7C-1c4oA:
undetectable
3wg7J-1c4oA:
0.0		 3wg7C-1c4oA:
16.59
3wg7J-1c4oA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 6 LEU A  58
PHE A 324
LEU A 320
PHE A  86
 None
 0.99A 3wg7P-1c4oA:
undetectable
3wg7W-1c4oA:
0.0		 3wg7P-1c4oA:
16.59
3wg7W-1c4oA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BQF_B_QPSB951_1
(ALPHA-GLUCAN
PHOSPHORYLASE 2,
CYTOSOLIC)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 8 ARG A 557
GLU A 560
GLU A 561
ARG A 565
 None
None
BOG  A9998 (-3.4A)
BOG  A9998 ( 4.9A)
 1.13A 4bqfB-1c4oA:
undetectable		 4bqfB-1c4oA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 4 PHE A 324
VAL A 133
ALA A  57
PHE A   3
 None
 1.47A 4f3tA-1c4oA:
undetectable		 4f3tA-1c4oA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G24_A_ACAA1004_1
(PENTATRICOPEPTIDE
REPEAT-CONTAINING
PROTEIN AT2G32230,
MITOCHONDRIAL)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 6 ALA A  17
LEU A  21
VAL A  22
GLU A  51
 None
 1.02A 4g24A-1c4oA:
undetectable		 4g24A-1c4oA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_1
(NEURAMINIDASE)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		3 / 3 ARG A 284
GLU A 107
ARG A 362
 None
 0.67A 4mwvA-1c4oA:
undetectable		 4mwvA-1c4oA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NJV_D_RITD500_1
(PROTEASE)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		5 / 11 GLY A 534
ILE A 406
GLY A  36
PRO A 409
THR A 410
 None
 1.01A 4njvC-1c4oA:
0.0		 4njvC-1c4oA:
9.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		5 / 12 ILE A 506
THR A 457
ARG A 442
LEU A 486
LEU A 499
 None
 1.03A 4qzuA-1c4oA:
undetectable		 4qzuA-1c4oA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RYA_A_MTLA501_1
(ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (SORBITOL))		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		3 / 3 GLU A 264
TYR A 307
GLU A 257
 None
 0.79A 4ryaA-1c4oA:
0.9		 4ryaA-1c4oA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 4 PHE A 324
VAL A 133
ALA A  57
PHE A   3
 None
 1.44A 4w5qA-1c4oA:
undetectable		 4w5qA-1c4oA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5R_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 4 PHE A 324
VAL A 133
ALA A  57
PHE A   3
 None
 1.49A 4w5rA-1c4oA:
0.0		 4w5rA-1c4oA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 4 PHE A 324
VAL A 133
ALA A  57
PHE A   3
 None
 1.48A 4w5tA-1c4oA:
0.0		 4w5tA-1c4oA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4G_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 4 PHE A 324
VAL A 133
ALA A  57
PHE A   3
 None
 1.43A 4z4gA-1c4oA:
0.0		 4z4gA-1c4oA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		5 / 12 SER A 247
PHE A 324
THR A 319
THR A 124
LEU A 128
 None
 1.44A 4z7fC-1c4oA:
0.7		 4z7fC-1c4oA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJQ_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		5 / 12 SER A 122
THR A 123
ILE A  65
PHE A 477
ARG A  75
 None
 1.48A 4zjqD-1c4oA:
0.0		 4zjqD-1c4oA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 6 GLN A 383
PHE A  31
PHE A 386
LEU A 332
 None
 1.16A 5b1bC-1c4oA:
undetectable
5b1bJ-1c4oA:
0.0		 5b1bC-1c4oA:
16.59
5b1bJ-1c4oA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 4 PHE A 324
VAL A 133
ALA A  57
PHE A   3
 None
 1.43A 5ki6A-1c4oA:
undetectable		 5ki6A-1c4oA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 6 LEU A 332
VAL A 330
LEU A  58
VAL A 381
 None
 0.95A 5x7zA-1c4oA:
0.0		 5x7zA-1c4oA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1c4o DNA NUCLEOTIDE
EXCISION REPAIR
ENZYME UVRB
(Thermus
thermophilus) 		4 / 8 TYR A 547
THR A 446
CYH A 493
TRP A 545
 None
 1.48A 6cnjD-1c4oA:
undetectable
6cnjE-1c4oA:
0.0		 6cnjD-1c4oA:
8.89
6cnjE-1c4oA:
7.38