SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c4p'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1c4p PROTEIN
(STREPTOKINASE)
(Streptococcus
dysgalactiae) 		4 / 6 ARG A 219
ILE A 270
PHE A 241
GLU A 198
 None
 1.48A 1nsiA-1c4pA:
0.0
1nsiB-1c4pA:
0.0		 1nsiA-1c4pA:
15.12
1nsiB-1c4pA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_A_H4BA600_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1c4p PROTEIN
(STREPTOKINASE)
(Streptococcus
dysgalactiae) 		4 / 7 ARG A 219
ILE A 270
PHE A 241
GLU A 198
 None
 1.42A 2nsiA-1c4pA:
0.0
2nsiB-1c4pA:
0.0		 2nsiA-1c4pA:
15.12
2nsiB-1c4pA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_B_H4BB601_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1c4p PROTEIN
(STREPTOKINASE)
(Streptococcus
dysgalactiae) 		4 / 7 PHE A 241
GLU A 198
ARG A 219
ILE A 270
 None
 1.47A 2nsiA-1c4pA:
0.0
2nsiB-1c4pA:
0.0		 2nsiA-1c4pA:
15.12
2nsiB-1c4pA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_C_H4BC602_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1c4p PROTEIN
(STREPTOKINASE)
(Streptococcus
dysgalactiae) 		4 / 7 ARG A 219
ILE A 270
PHE A 241
GLU A 198
 None
 1.48A 2nsiC-1c4pA:
0.0
2nsiD-1c4pA:
0.0		 2nsiC-1c4pA:
15.12
2nsiD-1c4pA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NSI_D_H4BD603_1
(PROTEIN (NITRIC
OXIDE SYNTHASE))		 1c4p PROTEIN
(STREPTOKINASE)
(Streptococcus
dysgalactiae) 		4 / 7 PHE A 241
GLU A 198
ARG A 219
ILE A 270
 None
 1.48A 2nsiC-1c4pA:
0.0
2nsiD-1c4pA:
0.0		 2nsiC-1c4pA:
15.12
2nsiD-1c4pA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q64_B_1UNB1001_2
(PROTEASE RETROPEPSIN)		 1c4p PROTEIN
(STREPTOKINASE)
(Streptococcus
dysgalactiae) 		3 / 3 ARG A 248
THR A 187
VAL A 158
 None
 0.92A 2q64A-1c4pA:
0.0		 2q64A-1c4pA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1c4p PROTEIN
(STREPTOKINASE)
(Streptococcus
dysgalactiae) 		4 / 7 ARG A 219
ILE A 270
PHE A 241
GLU A 198
 None
 1.47A 3e7gA-1c4pA:
0.0
3e7gB-1c4pA:
0.0		 3e7gA-1c4pA:
15.40
3e7gB-1c4pA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_B_H4BB1902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1c4p PROTEIN
(STREPTOKINASE)
(Streptococcus
dysgalactiae) 		4 / 7 PHE A 241
GLU A 198
ARG A 219
ILE A 270
 None
 1.50A 3e7gA-1c4pA:
0.0
3e7gB-1c4pA:
0.0		 3e7gA-1c4pA:
15.40
3e7gB-1c4pA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E7G_C_H4BC2902_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 1c4p PROTEIN
(STREPTOKINASE)
(Streptococcus
dysgalactiae) 		4 / 7 ARG A 219
ILE A 270
PHE A 241
GLU A 198
 None
 1.47A 3e7gC-1c4pA:
0.0
3e7gD-1c4pA:
0.0		 3e7gC-1c4pA:
15.40
3e7gD-1c4pA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1c4p PROTEIN
(STREPTOKINASE)
(Streptococcus
dysgalactiae) 		3 / 3 TYR A 275
TYR A 162
SER A 222
 None
 0.97A 5iktB-1c4pA:
undetectable		 5iktB-1c4pA:
12.93