SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c6v'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1c6v PROTEIN (SIV
INTEGRASE)
(Simian
immunodeficiency
virus) 		4 / 8 HIS A 156
ASN A 160
ASP A 163
ILE A 162
 None
 1.04A 4k0bA-1c6vA:
0.0		 4k0bA-1c6vA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_0
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1c6v PROTEIN (SIV
INTEGRASE)
(Simian
immunodeficiency
virus) 		4 / 8 HIS A 156
ASN A 160
ASP A 163
ILE A 162
 None
 1.05A 4l7iA-1c6vA:
0.0		 4l7iA-1c6vA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 1c6v PROTEIN (SIV
INTEGRASE)
(Simian
immunodeficiency
virus) 		5 / 11 ILE A 165
ALA A 169
LEU A 177
LEU A 158
ILE A 162
 None
 1.14A 4p66A-1c6vA:
undetectable		 4p66A-1c6vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 1c6v PROTEIN (SIV
INTEGRASE)
(Simian
immunodeficiency
virus) 		4 / 4 VAL A 180
ILE A 162
ASN A 155
VAL A  73
 None
 1.27A 5ajqA-1c6vA:
undetectable		 5ajqA-1c6vA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_2
(CYTOCHROME P450 3A5)		 1c6v PROTEIN (SIU89134)
(Simian
immunodeficiency
virus) 		3 / 3 ARG X 228
PHE X 223
LEU X 251
 None
 0.85A 5veuA-1c6vX:
undetectable		 5veuA-1c6vX:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_B_PCFB1802_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1c6v PROTEIN (SIV
INTEGRASE)
(Simian
immunodeficiency
virus) 		4 / 7 THR A  97
PHE A 121
VAL A 126
ILE A 110
 None
 1.19A 5vkqA-1c6vA:
0.0
5vkqB-1c6vA:
0.0		 5vkqA-1c6vA:
7.59
5vkqB-1c6vA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_D_PCFD1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 1c6v PROTEIN (SIV
INTEGRASE)
(Simian
immunodeficiency
virus) 		4 / 7 THR A  97
PHE A 121
VAL A 126
ILE A 110
 None
 1.19A 5vkqC-1c6vA:
0.0
5vkqD-1c6vA:
0.0		 5vkqC-1c6vA:
7.59
5vkqD-1c6vA:
7.59