SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c7k'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ACL_E_REAE504_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1c7k ZINC ENDOPROTEASE
(Streptomyces
caespitosus) 		5 / 11 ILE A  18
ALA A  21
ALA A  22
LEU A  34
ALA A  82
 None
 1.08A 2aclE-1c7kA:
undetectable		 2aclE-1c7kA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1c7k ZINC ENDOPROTEASE
(Streptomyces
caespitosus) 		4 / 6 ILE A  65
TYR A  95
LEU A  67
PHE A  66
 None
 1.12A 3adsA-1c7kA:
undetectable		 3adsA-1c7kA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_A_ADNA506_2
(ADENOSYLHOMOCYSTEINA
SE)		 1c7k ZINC ENDOPROTEASE
(Streptomyces
caespitosus) 		3 / 3 GLN A  56
THR A  57
LEU A  67
 None
 0.72A 3ondA-1c7kA:
2.2		 3ondA-1c7kA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OND_B_ADNB507_2
(ADENOSYLHOMOCYSTEINA
SE)		 1c7k ZINC ENDOPROTEASE
(Streptomyces
caespitosus) 		3 / 3 GLN A  56
THR A  57
LEU A  67
 None
 0.74A 3ondB-1c7kA:
undetectable		 3ondB-1c7kA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UVV_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1c7k ZINC ENDOPROTEASE
(Streptomyces
caespitosus) 		5 / 12 ILE A  18
ALA A  21
ALA A  22
LEU A  34
ALA A  82
 None
 1.08A 3uvvB-1c7kA:
undetectable		 3uvvB-1c7kA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K6I_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1c7k ZINC ENDOPROTEASE
(Streptomyces
caespitosus) 		5 / 12 ILE A  18
ALA A  21
ALA A  22
LEU A  34
ALA A  82
 None
 1.04A 4k6iA-1c7kA:
undetectable		 4k6iA-1c7kA:
23.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 1c7k ZINC ENDOPROTEASE
(Streptomyces
caespitosus) 		5 / 12 ASP A  68
GLY A  52
ASP A  49
PHE A  14
GLN A  71
 None
 1.37A 4wh5A-1c7kA:
0.2		 4wh5A-1c7kA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1c7k ZINC ENDOPROTEASE
(Streptomyces
caespitosus) 		4 / 8 TYR A   6
ILE A  65
TYR A  44
GLY A  86
 None
 0.90A 5esfA-1c7kA:
undetectable		 5esfA-1c7kA:
12.12