SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c7o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 1c7o CYSTALYSIN
(Treponema
denticola) 		5 / 10 THR A  68
PRO A  67
GLY A  66
THR A 275
GLY A 277
 None
 1.39A 1h4oA-1c7oA:
0.0
1h4oB-1c7oA:
undetectable		 1h4oA-1c7oA:
17.88
1h4oB-1c7oA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_C_BEZC1162_0
(PEROXIREDOXIN 5)		 1c7o CYSTALYSIN
(Treponema
denticola) 		5 / 9 THR A  68
PRO A  67
GLY A  66
THR A 275
GLY A 277
 None
 1.32A 1h4oC-1c7oA:
undetectable
1h4oD-1c7oA:
undetectable		 1h4oC-1c7oA:
17.88
1h4oD-1c7oA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_E_BEZE1162_0
(PEROXIREDOXIN 5)		 1c7o CYSTALYSIN
(Treponema
denticola) 		5 / 9 THR A  68
PRO A  67
GLY A  66
THR A 275
GLY A 277
 None
 1.30A 1h4oE-1c7oA:
0.0
1h4oF-1c7oA:
0.0		 1h4oE-1c7oA:
17.88
1h4oF-1c7oA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VL2_A_BEZA1162_0
(PEROXIREDOXIN-5)		 1c7o CYSTALYSIN
(Treponema
denticola) 		5 / 10 THR A  68
PRO A  67
GLY A  66
THR A 275
GLY A 277
 None
 1.29A 2vl2A-1c7oA:
0.0
2vl2C-1c7oA:
0.1		 2vl2A-1c7oA:
19.15
2vl2C-1c7oA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_B_SAMB602_1
(HYPOTHETICAL PROTEIN)		 1c7o CYSTALYSIN
(Treponema
denticola) 		3 / 3 GLU A 343
ASP A 355
TYR A 124
 None
PPG  A1500 ( 4.0A)
None
 0.69A 2yvlB-1c7oA:
3.5		 2yvlB-1c7oA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 1c7o CYSTALYSIN
(Treponema
denticola) 		3 / 3 GLN A 220
ASP A 228
GLN A 225
 None
 0.77A 4aztA-1c7oA:
4.6		 4aztA-1c7oA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGZ_A_CQAA302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1c7o CYSTALYSIN
(Treponema
denticola) 		4 / 7 GLU A  69
GLU A  70
TYR A  71
GLY A  66
 None
 1.06A 4fgzA-1c7oA:
4.3		 4fgzA-1c7oA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 1c7o CYSTALYSIN
(Treponema
denticola) 		5 / 9 VAL A 106
GLU A 134
ILE A 130
GLY A 115
ALA A 167
 None
 1.21A 4fwdA-1c7oA:
0.3		 4fwdA-1c7oA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1c7o CYSTALYSIN
(Treponema
denticola) 		3 / 3 ASN A 132
PHE A 127
TYR A 123
 None
None
PPG  A1500 (-3.6A)
 0.87A 4u15A-1c7oA:
0.0		 4u15A-1c7oA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_1
(TUBULIN BETA-2B
CHAIN)		 1c7o CYSTALYSIN
(Treponema
denticola) 		5 / 12 ASP A 203
LEU A  17
ASP A  40
SER A 248
PRO A 100
 PPG  A1500 (-3.0A)
PPG  A1500 (-3.5A)
None
PPG  A1500 ( 3.9A)
None
 1.38A 5hnzB-1c7oA:
3.1		 5hnzB-1c7oA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 1c7o CYSTALYSIN
(Treponema
denticola) 		3 / 3 LYS A 158
LEU A 168
ILE A 151
 None
 0.82A 5kc4A-1c7oA:
0.0		 5kc4A-1c7oA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1c7o CYSTALYSIN
(Treponema
denticola) 		4 / 6 TYR A 124
ASP A 362
GLY A 361
PHE A 360
 None
 1.06A 5nooC-1c7oA:
0.0		 5nooC-1c7oA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1431_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 1c7o CYSTALYSIN
(Treponema
denticola) 		4 / 5 HIS A  83
ASP A 293
TRP A  78
GLY A 289
 None
 1.37A 5x7pB-1c7oA:
0.0		 5x7pB-1c7oA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZOV_B_ASCB501_0
(PTS
ASCORBATE-SPECIFIC
SUBUNIT IIBC)		 1c7o CYSTALYSIN
(Treponema
denticola) 		5 / 12 PRO A 212
ILE A 322
GLN A 303
ALA A 373
ILE A 296
 None
 1.28A 5zovB-1c7oA:
0.0		 5zovB-1c7oA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPY_A_ACTA408_0
(THIOREDOXIN
REDUCTASE)		 1c7o CYSTALYSIN
(Treponema
denticola) 		3 / 3 PRO A 375
SER A 376
SER A 377
 None
 0.70A 6bpyA-1c7oA:
0.0		 6bpyA-1c7oA:
22.27