SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c7t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CMA_B_SAMB105_0
(PROTEIN (MET
REPRESSOR))
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 11 ARG A 454
LEU A 409
GLU A 405
HIS A 401
GLY A 416
SO4  A2001 (-3.8A)
None
None
None
None
1.18A 1cmaA-1c7tA:
undetectable
1cmaB-1c7tA:
undetectable
1cmaA-1c7tA:
8.93
1cmaB-1c7tA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 12 GLY A 682
SER A 738
HIS A 352
LEU A 170
LEU A 736
None
1.11A 1fm6D-1c7tA:
undetectable
1fm6D-1c7tA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
3 / 3 LEU A 410
PRO A 411
LEU A 112
None
0.49A 1hrkA-1c7tA:
undetectable
1hrkA-1c7tA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_C_COCC302_2
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION
CHIMERA OF IG
GAMMA-1 CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 4 GLU A 692
TYR A 674
PRO A 673
ASP A 691
None
1.49A 1i7zD-1c7tA:
1.5
1i7zD-1c7tA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJL_B_SAMB400_0
(METHIONINE REPRESSOR
PROTEIN METJ)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 9 ARG A 454
LEU A 409
GLU A 405
HIS A 401
GLY A 416
SO4  A2001 (-3.8A)
None
None
None
None
1.20A 1mjlA-1c7tA:
undetectable
1mjlB-1c7tA:
undetectable
1mjlA-1c7tA:
8.93
1mjlB-1c7tA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_A_SAMA200_0
(METHIONINE REPRESSOR)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 11 ARG A 454
LEU A 409
GLU A 405
HIS A 401
GLY A 416
SO4  A2001 (-3.8A)
None
None
None
None
1.19A 1mjqA-1c7tA:
undetectable
1mjqB-1c7tA:
undetectable
1mjqA-1c7tA:
8.93
1mjqB-1c7tA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_C_SAMC199_0
(METHIONINE REPRESSOR)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 10 ARG A 454
LEU A 409
GLU A 405
HIS A 401
GLY A 416
SO4  A2001 (-3.8A)
None
None
None
None
1.22A 1mjqC-1c7tA:
undetectable
1mjqD-1c7tA:
undetectable
1mjqC-1c7tA:
8.93
1mjqD-1c7tA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_I_SAMI199_0
(METHIONINE REPRESSOR)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 11 ARG A 454
LEU A 409
GLU A 405
HIS A 401
GLY A 416
SO4  A2001 (-3.8A)
None
None
None
None
1.23A 1mjqI-1c7tA:
undetectable
1mjqJ-1c7tA:
undetectable
1mjqI-1c7tA:
8.93
1mjqJ-1c7tA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_B_SAMB402_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 12 GLY A 302
GLY A 307
GLY A 287
ASP A 273
GLY A 277
None
0.93A 1n2xB-1c7tA:
undetectable
1n2xB-1c7tA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_SAMA500_0
(HISTONE
METHYLTRANSFERASE
DOT1L)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 12 TYR A 501
ASP A 618
GLY A 538
ALA A 453
PHE A 536
None
1.29A 1nw3A-1c7tA:
undetectable
1nw3A-1c7tA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
3 / 3 ASP A 111
THR A 109
GLU A 405
None
SO4  A2001 (-3.4A)
None
0.80A 1pj7A-1c7tA:
0.7
1pj7A-1c7tA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_B_ACTB861_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 5 GLY A 598
GLN A 599
VAL A 634
SER A 602
None
1.26A 1zzqB-1c7tA:
undetectable
1zzqB-1c7tA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 5 GLY A 598
GLN A 599
VAL A 634
SER A 602
None
1.22A 1zzuA-1c7tA:
0.1
1zzuA-1c7tA:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_2
(POL POLYPROTEIN)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
3 / 3 ASP A 346
ILE A 447
VAL A 443
None
0.71A 2avvD-1c7tA:
0.0
2avvD-1c7tA:
8.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COI_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 10 ARG A 612
GLY A 537
ALA A 615
TYR A 340
VAL A 661
None
1.49A 2coiA-1c7tA:
undetectable
2coiB-1c7tA:
undetectable
2coiA-1c7tA:
17.54
2coiB-1c7tA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 6 ARG A 870
GLU A 883
PRO A 195
ALA A 824
None
1.44A 2ejfB-1c7tA:
undetectable
2ejfB-1c7tA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FL5_F_RBFF204_1
(IMMUNOGLOBULIN IGG1
LAMBDA LIGHT CHAIN
IMMUNOGLOBULIN IGG1
HEAVY CHAIN)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 8 ASN A 503
ARG A 480
GLU A 461
VAL A 577
None
1.09A 2fl5E-1c7tA:
2.2
2fl5F-1c7tA:
2.2
2fl5E-1c7tA:
12.94
2fl5F-1c7tA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 4 LEU A 810
PRO A 753
LEU A 807
ARG A 805
None
1.41A 2hrcA-1c7tA:
0.3
2hrcA-1c7tA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ITZ_A_IREA2021_2
(EPIDERMAL GROWTH
FACTOR RECEPTOR)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
3 / 3 LEU A  96
LEU A  45
MET A  44
None
0.76A 2itzA-1c7tA:
undetectable
2itzA-1c7tA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
3 / 3 LEU A 410
PRO A 411
LEU A 112
None
0.52A 2po5B-1c7tA:
undetectable
2po5B-1c7tA:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
3 / 3 LEU A 410
PRO A 411
LEU A 112
None
0.57A 2po7B-1c7tA:
undetectable
2po7B-1c7tA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZGW_B_ADNB1302_1
(BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 6 GLU A 883
ALA A 833
PRO A 195
ALA A 824
None
1.20A 2zgwB-1c7tA:
undetectable
2zgwB-1c7tA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIA_A_CL9A401_2
(DEOXYCYTIDINE KINASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 4 VAL A 218
ASP A 794
LEU A 205
ARG A 805
None
1.48A 2ziaA-1c7tA:
undetectable
2ziaA-1c7tA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_B_SAMB402_0
(UNCHARACTERIZED
PROTEIN MJ0883)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 12 PHE A 597
LEU A 593
GLY A 538
PRO A 450
ASP A 640
None
1.33A 2zznB-1c7tA:
undetectable
2zznB-1c7tA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 12 PHE A 698
GLU A 769
LEU A 732
ARG A 337
ALA A 729
None
1.30A 3apxA-1c7tA:
0.0
3apxA-1c7tA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C0Z_A_SHHA301_1
(HISTONE DEACETYLASE
7A)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 5 HIS A 375
ASP A 448
HIS A 452
ASP A 539
None
None
CBS  A1001 (-4.2A)
CBS  A1001 (-3.9A)
1.21A 3c0zA-1c7tA:
undetectable
3c0zA-1c7tA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZY_D_BRLD478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 4 ILE A 441
GLN A 363
ILE A 432
LEU A 756
None
1.33A 3dzyD-1c7tA:
0.0
3dzyD-1c7tA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKX_B_1UNB201_1
(PROTEASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 11 GLY A 537
ALA A 615
VAL A 634
GLY A 598
THR A 631
None
0.95A 3ekxA-1c7tA:
undetectable
3ekxA-1c7tA:
8.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 7 GLU A 739
TYR A 669
PHE A 672
TYR A 683
CBS  A1001 (-2.7A)
CBS  A1001 (-4.4A)
CBS  A1001 (-4.7A)
CBS  A1001 (-4.1A)
1.32A 3ku9B-1c7tA:
undetectable
3ku9B-1c7tA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2V_A_RLTA397_1
(INTEGRASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 7 ASP A 448
ASP A 539
GLN A 614
GLU A 446
None
CBS  A1001 (-3.9A)
None
None
1.16A 3l2vA-1c7tA:
undetectable
3l2vA-1c7tA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
8 / 12 ARG A 349
ASP A 378
HIS A 452
ASP A 540
TYR A 669
ASP A 671
TRP A 737
GLU A 739
CBS  A1001 (-3.0A)
CBS  A1001 ( 4.8A)
CBS  A1001 (-4.2A)
CBS  A1001 ( 4.3A)
CBS  A1001 (-4.4A)
CBS  A1001 (-3.1A)
CBS  A1001 (-3.8A)
CBS  A1001 (-2.7A)
1.22A 3lmyA-1c7tA:
36.1
3lmyA-1c7tA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_A_CP6A562_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
11 / 12 ARG A 349
HIS A 375
ASP A 378
ASP A 448
HIS A 452
ASP A 539
TRP A 639
TYR A 669
ASP A 671
TRP A 737
GLU A 739
CBS  A1001 (-3.0A)
None
CBS  A1001 ( 4.8A)
None
CBS  A1001 (-4.2A)
CBS  A1001 (-3.9A)
CBS  A1001 (-3.5A)
CBS  A1001 (-4.4A)
CBS  A1001 (-3.1A)
CBS  A1001 (-3.8A)
CBS  A1001 (-2.7A)
0.44A 3lmyA-1c7tA:
36.1
3lmyA-1c7tA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
7 / 12 ARG A 349
ASP A 378
HIS A 452
ASP A 540
TYR A 669
TRP A 737
GLU A 739
CBS  A1001 (-3.0A)
CBS  A1001 ( 4.8A)
CBS  A1001 (-4.2A)
CBS  A1001 ( 4.3A)
CBS  A1001 (-4.4A)
CBS  A1001 (-3.8A)
CBS  A1001 (-2.7A)
1.28A 3lmyB-1c7tA:
36.1
3lmyB-1c7tA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
11 / 12 ARG A 349
HIS A 375
ASP A 378
ASP A 448
HIS A 452
ASP A 539
TRP A 616
TRP A 639
TYR A 669
TRP A 737
GLU A 739
CBS  A1001 (-3.0A)
None
CBS  A1001 ( 4.8A)
None
CBS  A1001 (-4.2A)
CBS  A1001 (-3.9A)
CBS  A1001 (-3.6A)
CBS  A1001 (-3.5A)
CBS  A1001 (-4.4A)
CBS  A1001 (-3.8A)
CBS  A1001 (-2.7A)
0.44A 3lmyB-1c7tA:
36.1
3lmyB-1c7tA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LMY_B_CP6B563_1
(BETA-HEXOSAMINIDASE
SUBUNIT BETA)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 12 HIS A 375
ASP A 378
GLU A 739
TYR A 669
TRP A 737
None
CBS  A1001 ( 4.8A)
CBS  A1001 (-2.7A)
CBS  A1001 (-4.4A)
CBS  A1001 (-3.8A)
1.34A 3lmyB-1c7tA:
36.1
3lmyB-1c7tA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 12 GLY A 325
GLY A 323
ALA A 231
LEU A 259
LEU A 233
None
1.03A 3mteB-1c7tA:
undetectable
3mteB-1c7tA:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N23_C_OBNC1_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 11 GLN A 229
ASP A 232
LEU A 233
VAL A 237
ALA A 238
None
1.37A 3n23C-1c7tA:
0.1
3n23C-1c7tA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 8 SER A 697
ASP A 204
LEU A 205
ASP A 691
None
1.24A 3n2oC-1c7tA:
7.6
3n2oD-1c7tA:
6.2
3n2oC-1c7tA:
22.90
3n2oD-1c7tA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVC_A_SALA370_1
(GENTISATE
1,2-DIOXYGENASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 6 GLN A 494
ARG A 349
HIS A 375
ASP A 379
CBS  A1001 ( 4.2A)
CBS  A1001 (-3.0A)
None
None
0.92A 3nvcA-1c7tA:
undetectable
3nvcA-1c7tA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 12 GLY A 325
GLY A 323
ALA A 231
LEU A 259
LEU A 233
None
1.04A 3p2kA-1c7tA:
undetectable
3p2kA-1c7tA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 12 GLY A 325
GLY A 323
ALA A 231
LEU A 259
LEU A 233
None
1.07A 3p2kB-1c7tA:
undetectable
3p2kB-1c7tA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 12 GLY A 325
GLY A 323
ALA A 231
LEU A 259
LEU A 233
None
1.04A 3p2kC-1c7tA:
undetectable
3p2kC-1c7tA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_D_SAMD6735_0
(16S RRNA METHYLASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 12 GLY A 325
GLY A 323
ALA A 231
LEU A 259
LEU A 233
None
1.03A 3p2kD-1c7tA:
undetectable
3p2kD-1c7tA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R55_A_PZAA598_0
(LACTOPEROXIDASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
3 / 3 GLU A 290
PHE A 279
GLN A 275
None
0.89A 3r55A-1c7tA:
0.0
3r55A-1c7tA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3O_A_DLUA399_1
(PFV INTEGRASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 7 ASP A 448
ASP A 539
GLN A 614
GLU A 446
None
CBS  A1001 (-3.9A)
None
None
1.15A 3s3oA-1c7tA:
undetectable
3s3oA-1c7tA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 8 VAL A 636
VAL A 661
ASP A 618
GLN A 617
None
1.03A 3uy4A-1c7tA:
2.6
3uy4A-1c7tA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
3 / 3 LEU A 410
PRO A 411
LEU A 112
None
0.48A 3w1wB-1c7tA:
undetectable
3w1wB-1c7tA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZOA_A_ACRA1587_2
(TREHALOSE
SYNTHASE/AMYLASE
TRES)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
3 / 3 ARG A 337
PHE A 338
PRO A 339
None
0.81A 3zoaB-1c7tA:
10.2
3zoaB-1c7tA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 7 GLU A 380
GLU A 739
HIS A 373
VAL A 357
None
CBS  A1001 (-2.7A)
None
None
1.01A 4a97A-1c7tA:
3.1
4a97A-1c7tA:
16.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYS_A_ACTA402_0
(MCCC FAMILY PROTEIN)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 6 ASP A 648
SER A 722
ASP A 723
GLU A 777
None
1.14A 4eysA-1c7tA:
undetectable
4eysA-1c7tA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_B_SASB804_1
(SEPIAPTERIN
REDUCTASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 12 PHE A 798
TRP A 795
PRO A 753
GLY A 803
LEU A 837
None
1.11A 4j7xB-1c7tA:
2.0
4j7xB-1c7tA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JQ4_A_IMNA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 10 VAL A 237
TYR A 268
VAL A 263
LEU A 318
LEU A 316
None
1.38A 4jq4A-1c7tA:
11.2
4jq4A-1c7tA:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
3 / 3 LEU A 819
PRO A 820
ARG A 854
None
0.61A 4klrB-1c7tA:
undetectable
4klrB-1c7tA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 6 SER A 500
GLY A 619
ASP A 618
GLY A 537
None
0.88A 4koeA-1c7tA:
0.0
4koeB-1c7tA:
0.0
4koeC-1c7tA:
undetectable
4koeA-1c7tA:
20.55
4koeB-1c7tA:
20.55
4koeC-1c7tA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 7 SER A 500
GLY A 619
ASP A 618
GLY A 537
None
0.84A 4koeA-1c7tA:
undetectable
4koeB-1c7tA:
undetectable
4koeD-1c7tA:
undetectable
4koeA-1c7tA:
20.55
4koeB-1c7tA:
20.55
4koeD-1c7tA:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 6 ASN A 719
GLU A 782
GLU A 708
TYR A 778
GLU A 777
None
1.27A 4mi4A-1c7tA:
undetectable
4mi4A-1c7tA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 7 ASN A 719
GLU A 782
GLU A 708
TYR A 778
GLU A 777
None
1.27A 4mi4B-1c7tA:
undetectable
4mi4C-1c7tA:
0.0
4mi4B-1c7tA:
11.32
4mi4C-1c7tA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 7 ASN A 719
GLU A 782
TYR A 778
GLU A 777
ARG A 776
None
1.36A 4mi4B-1c7tA:
undetectable
4mi4C-1c7tA:
0.0
4mi4B-1c7tA:
11.32
4mi4C-1c7tA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 7 ASN A 719
GLU A 782
GLU A 708
TYR A 778
GLU A 777
None
1.27A 4mi4A-1c7tA:
undetectable
4mi4C-1c7tA:
0.0
4mi4A-1c7tA:
11.32
4mi4C-1c7tA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 8 ASN A 719
GLU A 782
GLU A 708
TYR A 778
GLU A 777
None
1.27A 4mj8A-1c7tA:
0.1
4mj8C-1c7tA:
undetectable
4mj8A-1c7tA:
11.10
4mj8C-1c7tA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 8 ASN A 719
GLU A 782
GLU A 708
TYR A 778
GLU A 777
None
1.26A 4mj8B-1c7tA:
undetectable
4mj8C-1c7tA:
0.0
4mj8B-1c7tA:
11.10
4mj8C-1c7tA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 7 ASN A 719
GLU A 782
GLU A 708
TYR A 778
GLU A 777
None
1.43A 4mj8C-1c7tA:
0.0
4mj8C-1c7tA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_B_FK5B203_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
3 / 3 ALA A 196
GLN A 868
GLY A 848
None
0.63A 4odoC-1c7tA:
0.0
4odoC-1c7tA:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_2
(GLUCOCORTICOID
RECEPTOR)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
3 / 3 LEU A 506
MET A 460
TYR A 501
None
0.87A 4p6xG-1c7tA:
undetectable
4p6xG-1c7tA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_2
(HISTONE DEACETYLASE
8)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 11 TYR A 683
HIS A 373
HIS A 375
ASP A 448
GLY A 537
CBS  A1001 (-4.1A)
None
None
None
None
1.46A 4qa0B-1c7tA:
undetectable
4qa0B-1c7tA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 5 GLU A 782
GLU A 708
TYR A 778
GLU A 777
None
1.13A 4r87E-1c7tA:
0.0
4r87E-1c7tA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_G_SPMG202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 9 ASN A 719
GLU A 782
GLU A 708
TYR A 778
GLU A 777
None
1.32A 4r87E-1c7tA:
0.0
4r87G-1c7tA:
0.0
4r87E-1c7tA:
11.10
4r87G-1c7tA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_H_SPMH202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 6 ASN A 719
GLU A 782
TYR A 778
GLU A 777
None
1.01A 4r87H-1c7tA:
0.0
4r87H-1c7tA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 7 ASN A 719
GLU A 782
GLU A 708
TYR A 778
GLU A 777
None
1.30A 4r87I-1c7tA:
0.0
4r87I-1c7tA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_K_SPMK202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 9 ASN A 719
GLU A 782
GLU A 708
TYR A 778
GLU A 777
None
1.21A 4r87I-1c7tA:
0.0
4r87K-1c7tA:
0.0
4r87I-1c7tA:
11.10
4r87K-1c7tA:
11.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 5 SER A 697
LYS A 694
ARG A 693
LEU A 791
None
1.16A 4xdtA-1c7tA:
0.0
4xdtA-1c7tA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP9_C_1WEC706_1
(TRANSPORTER)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 4 PHE A 423
ASP A 428
GLY A 422
SER A 425
None
1.30A 4xp9C-1c7tA:
0.0
4xp9C-1c7tA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_1
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
3 / 3 SER A 488
GLU A 461
GLU A 473
None
0.74A 4ymgB-1c7tA:
0.7
4ymgB-1c7tA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 6 LEU A 205
ASN A 800
PRO A 838
ARG A 825
None
1.37A 4yv5B-1c7tA:
0.0
4yv5B-1c7tA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 6 LEU A 205
ASN A 800
PRO A 838
ARG A 825
None
1.36A 4yv5A-1c7tA:
0.0
4yv5A-1c7tA:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 6 GLY A 619
ASP A 618
GLY A 537
SER A 500
None
0.90A 4z53A-1c7tA:
undetectable
4z53B-1c7tA:
undetectable
4z53A-1c7tA:
22.48
4z53B-1c7tA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 7 GLY A 619
ASP A 618
GLY A 537
SER A 500
None
0.84A 4z53A-1c7tA:
undetectable
4z53B-1c7tA:
undetectable
4z53A-1c7tA:
22.48
4z53B-1c7tA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 7 ASP A 346
ARG A 349
GLY A 381
GLU A 380
None
CBS  A1001 (-3.0A)
None
None
0.80A 5bs8A-1c7tA:
0.0
5bs8C-1c7tA:
0.0
5bs8D-1c7tA:
undetectable
5bs8A-1c7tA:
21.29
5bs8C-1c7tA:
21.29
5bs8D-1c7tA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BS8_H_MFXH101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 7 ASP A 346
ARG A 349
GLY A 381
GLU A 380
None
CBS  A1001 (-3.0A)
None
None
0.81A 5bs8A-1c7tA:
undetectable
5bs8B-1c7tA:
undetectable
5bs8C-1c7tA:
0.0
5bs8A-1c7tA:
21.29
5bs8B-1c7tA:
15.47
5bs8C-1c7tA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 7 ASP A 346
ARG A 349
GLY A 381
GLU A 380
None
CBS  A1001 (-3.0A)
None
None
0.83A 5btaA-1c7tA:
0.0
5btaC-1c7tA:
0.0
5btaD-1c7tA:
undetectable
5btaA-1c7tA:
21.46
5btaC-1c7tA:
21.46
5btaD-1c7tA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_E_GFNE101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
GGTCATGAATGACTATGCAC
GTAA)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 7 ASP A 346
ARG A 349
GLY A 381
GLU A 380
None
CBS  A1001 (-3.0A)
None
None
0.81A 5btdA-1c7tA:
0.0
5btdB-1c7tA:
0.0
5btdC-1c7tA:
0.0
5btdA-1c7tA:
21.29
5btdB-1c7tA:
15.47
5btdC-1c7tA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTD_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 7 ASP A 346
ARG A 349
GLY A 381
GLU A 380
None
CBS  A1001 (-3.0A)
None
None
0.79A 5btdA-1c7tA:
0.0
5btdC-1c7tA:
0.0
5btdD-1c7tA:
undetectable
5btdA-1c7tA:
21.29
5btdC-1c7tA:
21.29
5btdD-1c7tA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 7 ASP A 346
ARG A 349
GLY A 381
GLU A 380
None
CBS  A1001 (-3.0A)
None
None
0.81A 5btfA-1c7tA:
0.0
5btfB-1c7tA:
undetectable
5btfC-1c7tA:
0.0
5btfA-1c7tA:
21.46
5btfB-1c7tA:
15.47
5btfC-1c7tA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_G_GFNG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 7 ASP A 346
ARG A 349
GLY A 381
GLU A 380
None
CBS  A1001 (-3.0A)
None
None
0.75A 5btfA-1c7tA:
0.0
5btfC-1c7tA:
0.0
5btfD-1c7tA:
undetectable
5btfA-1c7tA:
21.46
5btfC-1c7tA:
21.46
5btfD-1c7tA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTG_F_LFXF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 7 ASP A 346
ARG A 349
GLY A 381
GLU A 380
None
CBS  A1001 (-3.0A)
None
None
0.90A 5btgA-1c7tA:
undetectable
5btgC-1c7tA:
0.0
5btgD-1c7tA:
undetectable
5btgA-1c7tA:
21.29
5btgC-1c7tA:
21.29
5btgD-1c7tA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5C6P_A_4YHA601_1
(PROTEIN C)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 6 ALA A 157
SER A 154
GLN A  34
SER A  36
None
1.19A 5c6pA-1c7tA:
0.0
5c6pA-1c7tA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_2
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
3 / 3 GLU A 769
TRP A 726
ASN A 706
None
1.15A 5dv4A-1c7tA:
1.3
5dv4A-1c7tA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
3 / 3 THR A 846
SER A 845
TYR A 844
None
0.84A 5jsdA-1c7tA:
1.6
5jsdA-1c7tA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
3 / 3 THR A 846
SER A 845
TYR A 844
None
0.85A 5jsdB-1c7tA:
0.9
5jsdB-1c7tA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
3 / 3 THR A 846
SER A 845
TYR A 844
None
0.84A 5jsdC-1c7tA:
0.8
5jsdC-1c7tA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
3 / 3 THR A 846
SER A 845
TYR A 844
None
0.84A 5jseA-1c7tA:
1.6
5jseA-1c7tA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
3 / 3 THR A 846
SER A 845
TYR A 844
None
0.83A 5jseB-1c7tA:
1.2
5jseB-1c7tA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
3 / 3 THR A 846
SER A 845
TYR A 844
None
0.83A 5jseC-1c7tA:
1.2
5jseC-1c7tA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 6 GLU A 380
THR A 740
TYR A 413
PHE A 496
None
1.23A 5lrbA-1c7tA:
1.5
5lrbA-1c7tA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 6 GLU A 806
ALA A 808
LEU A 807
SER A 321
None
1.03A 5phhA-1c7tA:
0.0
5phhA-1c7tA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_0
(REGULATORY PROTEIN
TETR)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 12 ALA A 816
GLU A 692
LEU A 819
ARG A 881
ASP A 691
None
1.40A 5vlmC-1c7tA:
0.0
5vlmC-1c7tA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B0I_B_TA1B502_1
(TUBULIN BETA CHAIN)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
5 / 12 LEU A 291
ASP A 331
LEU A 330
ALA A 328
LEU A 233
None
1.09A 6b0iB-1c7tA:
undetectable
6b0iB-1c7tA:
7.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 4 ARG A 198
GLU A 675
GLU A 883
ARG A 881
None
1.02A 6fk2A-1c7tA:
undetectable
6fk2A-1c7tA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 4 ARG A 881
GLU A 883
GLU A 675
ARG A 198
None
1.00A 6fk2A-1c7tA:
undetectable
6fk2A-1c7tA:
9.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_A_LLLA301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 6 ASP A 346
TYR A 413
GLU A 380
ASP A 379
None
1.41A 6mn5A-1c7tA:
0.0
6mn5A-1c7tA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 6 ASP A 346
TYR A 413
GLU A 380
ASP A 379
None
1.40A 6mn5C-1c7tA:
0.0
6mn5C-1c7tA:
6.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN8_A_GLYA607_0
(UNCHARACTERIZED
PROTEIN)
1c7t BETA-N-ACETYLHEXOSAM
INIDASE

(Serratia
marcescens)
4 / 4 GLU A 446
ASP A 346
ARG A 349
TRP A 737
None
None
CBS  A1001 (-3.0A)
CBS  A1001 (-3.8A)
1.01A 6mn8A-1c7tA:
0.2
6mn8A-1c7tA:
19.19