SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c8b'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_2
(CYTOCHROME P450 2C8)		 1c8b SPORE PROTEASE
(Bacillus
megaterium) 		5 / 8 ILE A 590
ILE A 628
ILE A 509
ASN A 586
VAL A 582
 None
 1.20A 2nniA-1c8bA:
0.0		 2nniA-1c8bA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQC_K_AG2K671_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE (EC
4.1.1.19) (PVLARGDC))		 1c8b SPORE PROTEASE
(Bacillus
megaterium) 		5 / 8 GLN A 609
LEU A 596
ASP A 594
LEU A 530
GLY A 531
 None
 1.46A 2qqcH-1c8bA:
0.0
2qqcK-1c8bA:
0.0		 2qqcH-1c8bA:
15.14
2qqcK-1c8bA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1c8b SPORE PROTEASE
(Bacillus
megaterium) 		5 / 8 ALA A 561
LEU A 538
LEU A 753
VAL A 649
ILE A 651
 None
 1.33A 2uxpA-1c8bA:
undetectable		 2uxpA-1c8bA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB201_1
(PROTEIN S100-A4)		 1c8b SPORE PROTEASE
(Bacillus
megaterium) 		4 / 8 GLY A 620
ILE A 742
MET A 745
PHE A 496
 None
 0.92A 3ko0B-1c8bA:
undetectable
3ko0J-1c8bA:
undetectable		 3ko0B-1c8bA:
13.75
3ko0J-1c8bA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_K_TFPK201_1
(PROTEIN S100-A4)		 1c8b SPORE PROTEASE
(Bacillus
megaterium) 		4 / 8 GLY A 620
ILE A 742
MET A 745
PHE A 496
 None
 0.99A 3ko0K-1c8bA:
undetectable
3ko0S-1c8bA:
undetectable		 3ko0K-1c8bA:
13.75
3ko0S-1c8bA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1c8b SPORE PROTEASE
(Bacillus
megaterium) 		5 / 12 VAL A 563
GLY A 565
ILE A 742
ALA A 534
ALA A 746
 None
 1.01A 3sufB-1c8bA:
undetectable		 3sufB-1c8bA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1c8b SPORE PROTEASE
(Bacillus
megaterium) 		5 / 12 VAL A 563
GLY A 565
ILE A 742
ALA A 534
ALA A 746
 None
 0.94A 3sufD-1c8bA:
undetectable		 3sufD-1c8bA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OM2_B_DXTB501_1
(ALPHA-1-ANTICHYMOTRY
PSIN)		 1c8b SPORE PROTEASE
(Bacillus
megaterium) 		5 / 9 VAL A 649
LEU A 753
ALA A 750
VAL A 517
ILE A 591
 None
 1.19A 5om2A-1c8bA:
0.0
5om2B-1c8bA:
undetectable		 5om2A-1c8bA:
12.28
5om2B-1c8bA:
8.46