SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c8o'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWJ_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 1c8o ICE INHIBITOR
(Cowpox
virus) 		3 / 3 ILE A 279
ASP A 276
PHE A 259
 None
 0.60A 1uwjB-1c8oA:
undetectable		 1uwjB-1c8oA:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_A_FOLA1161_0
(DIHYDROFOLATE
REDUCTASE)		 1c8o ICE INHIBITOR
(Cowpox
virus) 		5 / 12 PHE A 141
ILE A 186
LEU A 188
PRO A 189
ILE A 235
 None
 0.93A 2d0kA-1c8oA:
undetectable		 2d0kA-1c8oA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IZQ_B_DVAB6_0
(GRAMICIDIN D)		 1c8o ICE INHIBITOR
(Cowpox
virus) 		3 / 3 TRP A 137
ALA A 293
VAL A 286
 None
 0.82A 2izqA-1c8oA:
undetectable
2izqB-1c8oA:
undetectable		 2izqA-1c8oA:
4.96
2izqB-1c8oA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z97_A_CAMA422_0
(CYTOCHROME P450-CAM)		 1c8o ICE INHIBITOR
(Cowpox
virus) 		4 / 6 THR A  38
VAL A 275
VAL A 251
VAL A 247
 None
 0.98A 2z97A-1c8oA:
undetectable		 2z97A-1c8oA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZN_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 1c8o ICE INHIBITOR
(Cowpox
virus) 		5 / 12 LEU A 214
GLY A 206
ILE A 204
ASN A 203
PHE A 151
 None
 1.31A 2zznA-1c8oA:
0.0		 2zznA-1c8oA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A8I_A_C2FA401_0
(AMINOMETHYLTRANSFERA
SE)		 1c8o ICE INHIBITOR
(Cowpox
virus) 		5 / 12 ILE A  29
VAL A  26
MET A 278
PHE A  77
TYR A  66
 None
 1.29A 3a8iA-1c8oA:
undetectable		 3a8iA-1c8oA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJO_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P)		 1c8o ICE INHIBITOR
(Cowpox
virus) 		4 / 8 PHE A 151
VAL A 161
VAL A 153
VAL A 240
 None
 0.77A 3hjoB-1c8oA:
undetectable		 3hjoB-1c8oA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_A_SAMA301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1c8o ICE INHIBITOR
(Cowpox
virus) 		3 / 3 SER A 274
ASP A 276
ASP A 264
 None
 0.82A 3iv6A-1c8oA:
undetectable		 3iv6A-1c8oA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_1
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 1c8o ICE INHIBITOR
(Cowpox
virus) 		3 / 3 SER A 274
ASP A 276
ASP A 264
 None
 0.80A 3iv6C-1c8oA:
undetectable		 3iv6C-1c8oA:
25.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_A_DVAA6_0
(GRAMICIDIN D)		 1c8o ICE INHIBITOR
(Cowpox
virus) 		3 / 3 ALA A 293
VAL A 286
TRP A 137
 None
 0.84A 3l8lA-1c8oA:
undetectable
3l8lB-1c8oA:
undetectable		 3l8lA-1c8oA:
4.96
3l8lB-1c8oA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 1c8o ICE INHIBITOR
(Cowpox
virus) 		4 / 8 HIS A 280
ILE A 279
SER A 298
ILE A 128
 None
 1.06A 3sfeB-1c8oA:
undetectable
3sfeC-1c8oA:
undetectable		 3sfeB-1c8oA:
20.39
3sfeC-1c8oA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1c8o ICE INHIBITOR
(Cowpox
virus) 		5 / 11 ILE A  18
ILE A  23
VAL A  26
LEU A  27
VAL A 258
 None
 1.03A 3w67A-1c8oA:
undetectable		 3w67A-1c8oA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1c8o ICE INHIBITOR
(Cowpox
virus) 		5 / 12 VAL A  46
THR A  38
TYR A  32
ILE A   3
LYS A   1
 None
 1.28A 4eb6B-1c8oA:
undetectable
4eb6C-1c8oA:
undetectable		 4eb6B-1c8oA:
21.73
4eb6C-1c8oA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 1c8o ICE INHIBITOR
(Cowpox
virus) 		4 / 4 LEU A  27
SER A  22
LEU A 246
LEU A  30
 None
 1.07A 4n09A-1c8oA:
undetectable		 4n09A-1c8oA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PWD_C_NVPC901_1
(HIV-1 REVERSE
TRANSCRIPTASE, P66
SUBUNIT)		 1c8o ICE INHIBITOR
(Cowpox
virus) 		4 / 8 LEU A  27
VAL A 258
LEU A 250
TYR A  45
 None
 1.09A 4pwdC-1c8oA:
undetectable		 4pwdC-1c8oA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1c8o ICE INHIBITOR
(Cowpox
virus) 		5 / 12 ILE A 235
PRO A 236
GLY A 242
THR A 282
TYR A 283
 None
 0.90A 5igtA-1c8oA:
0.0		 5igtA-1c8oA:
21.82