SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c8u'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		5 / 12 LEU A 241
PHE A  60
GLY A  41
TYR A 201
LEU A   9
 None
 1.38A 1brpA-1c8uA:
0.5		 1brpA-1c8uA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		5 / 12 PHE A  60
GLY A  41
TYR A 201
LEU A   9
HIS A 231
 None
 1.26A 1brpA-1c8uA:
0.5		 1brpA-1c8uA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		5 / 11 LEU A  44
PHE A  60
GLY A 200
SER A 203
HIS A 231
 None
 1.14A 1mx1A-1c8uA:
undetectable		 1mx1A-1c8uA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_C_CHDC310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		5 / 7 LEU A  56
GLN A 109
PHE A 108
LEU A 192
PHE A 239
 None
 1.43A 2dysC-1c8uA:
undetectable
2dysJ-1c8uA:
0.0		 2dysC-1c8uA:
22.53
2dysJ-1c8uA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZXW_C_CHDC271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		5 / 7 LEU A  56
GLN A 109
PHE A 108
LEU A 192
PHE A 239
 None
 1.46A 2zxwC-1c8uA:
0.0
2zxwJ-1c8uA:
0.0		 2zxwC-1c8uA:
22.53
2zxwJ-1c8uA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		5 / 12 GLN A  33
GLY A 200
SER A  62
LEU A  44
ALA A  43
 None
 1.09A 3d91A-1c8uA:
undetectable		 3d91A-1c8uA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FXR_A_ASCA3001_0
(LYSR TYPE REGULATOR
OF TSAMBCD)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		4 / 8 ALA A 137
ILE A 136
PRO A 131
PRO A 162
 None
 0.84A 3fxrA-1c8uA:
undetectable		 3fxrA-1c8uA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		4 / 6 VAL A  57
LEU A   8
ILE A 182
LEU A  44
 None
 0.89A 3kk6A-1c8uA:
0.0		 3kk6A-1c8uA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		4 / 6 VAL A  57
LEU A   8
ILE A 182
LEU A  44
 None
 0.89A 3kk6B-1c8uA:
0.0		 3kk6B-1c8uA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		4 / 7 GLN A  96
SER A  70
LEU A  12
ILE A  74
 None
 0.88A 3ln1C-1c8uA:
0.0		 3ln1C-1c8uA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_F_CLMF221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		5 / 10 PHE A 207
TYR A 247
PHE A 265
PHE A  60
VAL A  40
 None
 1.50A 3u9fD-1c8uA:
0.0
3u9fF-1c8uA:
0.0		 3u9fD-1c8uA:
23.39
3u9fF-1c8uA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_O_CLMO221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		5 / 11 PHE A 207
TYR A 247
PHE A 265
PHE A  60
VAL A  40
 None
 1.50A 3u9fM-1c8uA:
0.0
3u9fO-1c8uA:
0.0		 3u9fM-1c8uA:
23.39
3u9fO-1c8uA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FE1_A_PQNA846_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		5 / 10 ALA A   4
LEU A   5
GLY A 186
ALA A  43
MET A 104
 None
 1.48A 4fe1A-1c8uA:
undetectable
4fe1J-1c8uA:
0.0		 4fe1A-1c8uA:
15.61
4fe1J-1c8uA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		3 / 3 TYR A 266
ARG A 237
HIS A 236
 None
 1.09A 4fubA-1c8uA:
0.0		 4fubA-1c8uA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_A_STRA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		5 / 11 GLN A  42
ALA A  43
ALA A  46
ALA A  47
THR A  50
 None
 1.01A 4j6cA-1c8uA:
0.0		 4j6cA-1c8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6C_B_STRB503_1
(CYTOCHROME P450
MONOOXYGENASE)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		5 / 10 GLN A  42
ALA A  43
ALA A  46
ALA A  47
THR A  50
 None
 1.03A 4j6cB-1c8uA:
0.0		 4j6cB-1c8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_A_TESA503_1
(CYTOCHROME P450
MONOOXYGENASE)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		5 / 12 GLN A  42
ALA A  43
ALA A  46
ALA A  47
THR A  50
 None
 1.05A 4j6dA-1c8uA:
undetectable		 4j6dA-1c8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J6D_B_TESB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		5 / 12 GLN A  42
ALA A  43
ALA A  46
ALA A  47
THR A  50
 None
 1.07A 4j6dB-1c8uA:
undetectable		 4j6dB-1c8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_A_ASDA501_1
(CYTOCHROME P450
MONOOXYGENASE)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		5 / 12 GLN A  42
ALA A  43
ALA A  46
ALA A  47
THR A  50
 None
 1.08A 4jbtA-1c8uA:
undetectable		 4jbtA-1c8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JBT_B_ASDB502_1
(CYTOCHROME P450
MONOOXYGENASE)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		5 / 11 GLN A  42
ALA A  43
ALA A  46
ALA A  47
THR A  50
 None
 1.07A 4jbtB-1c8uA:
undetectable		 4jbtB-1c8uA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MX0_A_BCZA513_1
(NEURAMINIDASE)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		3 / 3 ARG A 161
ASP A 128
ARG A 183
 None
 0.99A 4mx0A-1c8uA:
undetectable		 4mx0A-1c8uA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		4 / 4 LEU A 198
SER A 203
LEU A  44
LEU A   8
 None
 1.10A 4n09A-1c8uA:
undetectable		 4n09A-1c8uA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		5 / 12 PHE A 235
ALA A 274
THR A 276
ALA A 202
GLY A  41
 None
 1.12A 5veuA-1c8uA:
0.0		 5veuA-1c8uA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCN_A_8LXA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1c8u ACYL-COA
THIOESTERASE II
(Escherichia
coli) 		5 / 12 LEU A  56
ARG A 193
LEU A 245
VAL A 273
LEU A   5
 None
 1.02A 5ycnA-1c8uA:
0.0		 5ycnA-1c8uA:
21.56