SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c8x'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4008_1
(SERUM ALBUMIN)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		4 / 8 ALA A  46
LEU A  59
LEU A  88
ALA A 118
 ALA  A  46 ( 0.0A)
LEU  A  59 ( 0.6A)
LEU  A  88 ( 0.5A)
ALA  A 118 ( 0.0A)
 0.79A 1e7cA-1c8xA:
0.0		 1e7cA-1c8xA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IWH_A_PEMA501_1
(HEMOGLOBIN ALPHA
CHAIN)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		4 / 6 ALA A 110
LYS A 113
ASP A 117
ALA A 118
 ALA  A 110 ( 0.0A)
LYS  A 113 ( 0.0A)
ASP  A 117 ( 0.6A)
ALA  A 118 ( 0.0A)
 0.23A 1iwhA-1c8xA:
undetectable		 1iwhA-1c8xA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_1
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		5 / 12 ALA A  45
ALA A 173
TYR A 136
ILE A  48
LEU A 156
 ALA  A  45 ( 0.0A)
ALA  A 173 ( 0.0A)
TYR  A 136 ( 1.3A)
ILE  A  48 ( 0.6A)
LEU  A 156 ( 0.6A)
 1.05A 2nyrA-1c8xA:
undetectable		 2nyrA-1c8xA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		4 / 7 PHE A 149
VAL A 153
LEU A 115
SER A 116
 PHE  A 149 ( 1.3A)
VAL  A 153 ( 0.6A)
LEU  A 115 ( 0.6A)
SER  A 116 ( 0.0A)
 0.92A 3hs6B-1c8xA:
0.0		 3hs6B-1c8xA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L4D_D_TPFD490_1
(STEROL 14-ALPHA
DEMETHYLASE)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		4 / 8 PHE A  38
TYR A  28
ALA A  13
THR A 221
 PHE  A  38 ( 1.3A)
TYR  A  28 ( 1.3A)
ALA  A  13 ( 0.0A)
THR  A 221 ( 0.8A)
 1.06A 3l4dD-1c8xA:
undetectable		 3l4dD-1c8xA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_A_D16A520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		5 / 12 ALA A 205
ASP A 183
LEU A 177
ILE A 165
LEU A 167
 ALA  A 205 ( 0.0A)
ASP  A 183 ( 0.6A)
LEU  A 177 ( 0.6A)
ILE  A 165 ( 0.8A)
LEU  A 167 ( 0.5A)
 1.15A 3nrrA-1c8xA:
undetectable		 3nrrA-1c8xA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NRR_B_D16B520_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		5 / 12 ALA A 205
ASP A 183
LEU A 177
ILE A 165
LEU A 167
 ALA  A 205 ( 0.0A)
ASP  A 183 ( 0.6A)
LEU  A 177 ( 0.6A)
ILE  A 165 ( 0.8A)
LEU  A 167 ( 0.5A)
 1.13A 3nrrB-1c8xA:
undetectable		 3nrrB-1c8xA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VWQ_A_ACAA601_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		5 / 12 ALA A 174
TYR A  14
ASP A 128
GLY A 171
ILE A 170
 ALA  A 174 ( 0.0A)
TYR  A  14 (-1.3A)
ASP  A 128 ( 0.5A)
GLY  A 171 ( 0.0A)
ILE  A 170 ( 0.7A)
 1.20A 3vwqA-1c8xA:
undetectable		 3vwqA-1c8xA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLR_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		3 / 3 LEU A  79
PRO A  78
ARG A 269
 LEU  A  79 ( 0.6A)
PRO  A  78 ( 1.1A)
ARG  A 269 ( 0.6A)
 0.66A 4klrB-1c8xA:
undetectable		 4klrB-1c8xA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A303_1
(ANCESTRAL STEROID
RECEPTOR 2)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		5 / 9 ALA A  37
LEU A 262
PHE A 258
THR A 243
LEU A 246
 ALA  A  37 ( 0.0A)
LEU  A 262 ( 0.6A)
PHE  A 258 ( 1.3A)
THR  A 243 ( 0.8A)
LEU  A 246 ( 0.6A)
 1.34A 4ltwA-1c8xA:
undetectable		 4ltwA-1c8xA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		5 / 12 ASP A 128
LEU A 167
PHE A 111
ALA A 173
LEU A  91
 ASP  A 128 ( 0.5A)
LEU  A 167 ( 0.5A)
PHE  A 111 ( 1.3A)
ALA  A 173 ( 0.0A)
LEU  A  91 ( 0.6A)
 1.19A 4retA-1c8xA:
undetectable		 4retA-1c8xA:
13.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RKU_A_PQNA5001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		4 / 8 PHE A 102
SER A 104
ALA A 155
LEU A 152
 PHE  A 102 ( 1.3A)
SER  A 104 ( 0.0A)
ALA  A 155 ( 0.0A)
LEU  A 152 ( 0.6A)
 1.02A 4rkuA-1c8xA:
undetectable
4rkuJ-1c8xA:
0.0		 4rkuA-1c8xA:
16.15
4rkuJ-1c8xA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		4 / 7 PHE A 102
SER A 104
ALA A 155
LEU A 152
 PHE  A 102 ( 1.3A)
SER  A 104 ( 0.0A)
ALA  A 155 ( 0.0A)
LEU  A 152 ( 0.6A)
 1.09A 4xk8A-1c8xA:
undetectable		 4xk8A-1c8xA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XMF_A_HSMA202_1
(NITROPHORIN-7)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		3 / 3 ASP A  39
LEU A  30
GLY A  35
 ASP  A  39 ( 0.5A)
LEU  A  30 ( 0.6A)
GLY  A  35 ( 0.0A)
 0.57A 4xmfA-1c8xA:
0.0		 4xmfA-1c8xA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_A_ILEA601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		4 / 6 ALA A 253
THR A 252
VAL A 255
TYR A  28
 ALA  A 253 ( 0.0A)
THR  A 252 ( 0.8A)
VAL  A 255 ( 0.6A)
TYR  A  28 ( 1.3A)
 0.97A 5eckA-1c8xA:
undetectable		 5eckA-1c8xA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECK_D_ILED601_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		4 / 6 ALA A 253
THR A 252
VAL A 255
TYR A  28
 ALA  A 253 ( 0.0A)
THR  A 252 ( 0.8A)
VAL  A 255 ( 0.6A)
TYR  A  28 ( 1.3A)
 1.02A 5eckD-1c8xA:
undetectable		 5eckD-1c8xA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		4 / 8 ASP A 189
LYS A 187
VAL A  90
GLN A 106
 ASP  A 189 ( 0.6A)
LYS  A 187 ( 0.0A)
VAL  A  90 ( 0.6A)
GLN  A 106 ( 0.6A)
 1.24A 6fbvD-1c8xA:
0.0		 6fbvD-1c8xA:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		5 / 11 GLY A 239
LEU A 262
ALA A 230
TRP A 199
ALA A 214
 GLY  A 239 ( 0.0A)
LEU  A 262 ( 0.6A)
ALA  A 230 ( 0.0A)
TRP  A 199 ( 0.5A)
ALA  A 214 ( 0.0A)
 1.48A 6qgbA-1c8xA:
undetectable		 6qgbA-1c8xA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1c8x ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE H
(Streptomyces
plicatus) 		5 / 11 GLY A 239
LEU A 262
ALA A 230
TRP A 199
ALA A 214
 GLY  A 239 ( 0.0A)
LEU  A 262 ( 0.6A)
ALA  A 230 ( 0.0A)
TRP  A 199 ( 0.5A)
ALA  A 214 ( 0.0A)
 1.46A 6qgbE-1c8xA:
undetectable		 6qgbE-1c8xA:
19.86