SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c8z'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 1c8z TUBBY PROTEIN
(Mus
musculus) 		4 / 7 TYR A 464
LEU A 485
MET A 391
ILE A 422
 None
 1.15A 1tuvA-1c8zA:
undetectable		 1tuvA-1c8zA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X8V_A_ESLA471_1
(CYTOCHROME P450 51)		 1c8z TUBBY PROTEIN
(Mus
musculus) 		4 / 8 PHE A 498
PHE A 454
ALA A 490
LEU A 285
 None
 1.09A 1x8vA-1c8zA:
0.0		 1x8vA-1c8zA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 1c8z TUBBY PROTEIN
(Mus
musculus) 		5 / 10 ALA A 490
VAL A 386
VAL A 388
PRO A 389
VAL A 369
 None
 0.94A 2nnjA-1c8zA:
undetectable		 2nnjA-1c8zA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1c8z TUBBY PROTEIN
(Mus
musculus) 		6 / 12 LEU A 287
LEU A 297
LEU A 298
ILE A 245
LEU A 366
VAL A 342
 None
 1.09A 2pnjA-1c8zA:
undetectable		 2pnjA-1c8zA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V41_E_BEZE1222_0
(PEROXIREDOXIN 6.)		 1c8z TUBBY PROTEIN
(Mus
musculus) 		4 / 7 THR A 428
PRO A 429
VAL A 430
PRO A 381
 None
 1.02A 2v41E-1c8zA:
undetectable
2v41F-1c8zA:
undetectable		 2v41E-1c8zA:
20.88
2v41F-1c8zA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1c8z TUBBY PROTEIN
(Mus
musculus) 		5 / 11 TYR A 327
GLY A 329
ALA A 492
ASP A 344
GLN A 489
 None
 1.21A 3id5B-1c8zA:
0.0		 3id5B-1c8zA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 1c8z TUBBY PROTEIN
(Mus
musculus) 		5 / 11 TYR A 327
GLY A 329
ALA A 492
ASP A 344
GLN A 489
 None
 1.21A 3id5F-1c8zA:
0.0		 3id5F-1c8zA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1c8z TUBBY PROTEIN
(Mus
musculus) 		4 / 6 ALA A 254
ILE A 328
LEU A 298
GLU A 252
 None
 0.82A 3r9sA-1c8zA:
undetectable		 3r9sA-1c8zA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_C_BEZC264_0
(CARNITINYL-COA
DEHYDRATASE)		 1c8z TUBBY PROTEIN
(Mus
musculus) 		4 / 6 ALA A 254
ILE A 328
LEU A 298
GLU A 252
 None
 0.87A 3r9sC-1c8zA:
undetectable		 3r9sC-1c8zA:
23.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1c8z TUBBY PROTEIN
(Mus
musculus) 		5 / 8 LEU A 362
GLY A 346
VAL A 347
ALA A 352
LEU A 357
 None
 1.26A 4zauA-1c8zA:
undetectable		 4zauA-1c8zA:
23.24