SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c9e'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1c9e PROTOHEME FERROLYASE
(Bacillus
subtilis) 		4 / 6 PRO A  91
ALA A  98
GLU A 132
GLU A  94
 None
 1.45A 1qhyA-1c9eA:
1.8		 1qhyA-1c9eA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1c9e PROTOHEME FERROLYASE
(Bacillus
subtilis) 		3 / 3 VAL A 235
VAL A 180
ASP A 261
 None
 0.74A 2fumD-1c9eA:
0.0		 2fumD-1c9eA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA701_0
(FERROCHELATASE)		 1c9e PROTOHEME FERROLYASE
(Bacillus
subtilis) 		5 / 12 SER A 121
HIS A 183
LEU A 185
PRO A 186
TRP A 230
 MP1  A 800 (-3.4A)
MP1  A 800 (-3.6A)
MP1  A 800 (-4.8A)
MP1  A 800 (-4.6A)
None
 1.00A 2hrcA-1c9eA:
34.1		 2hrcA-1c9eA:
29.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_C_STIC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1c9e PROTOHEME FERROLYASE
(Bacillus
subtilis) 		4 / 6 LEU A 136
VAL A 112
MET A  11
ILE A  93
 None
 1.16A 2hyyC-1c9eA:
undetectable		 2hyyC-1c9eA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1c9e PROTOHEME FERROLYASE
(Bacillus
subtilis) 		5 / 12 SER A 118
HIS A 183
LEU A 185
PRO A 186
TRP A 230
 None
MP1  A 800 (-3.6A)
MP1  A 800 (-4.8A)
MP1  A 800 (-4.6A)
None
 1.04A 2po7A-1c9eA:
34.7		 2po7A-1c9eA:
28.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1c9e PROTOHEME FERROLYASE
(Bacillus
subtilis) 		5 / 12 SER A 121
HIS A 183
LEU A 185
PRO A 186
TRP A 230
 MP1  A 800 (-3.4A)
MP1  A 800 (-3.6A)
MP1  A 800 (-4.8A)
MP1  A 800 (-4.6A)
None
 1.05A 2po7A-1c9eA:
34.7		 2po7A-1c9eA:
28.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1c9e PROTOHEME FERROLYASE
(Bacillus
subtilis) 		5 / 12 SER A 118
HIS A 183
LEU A 185
PRO A 186
TRP A 230
 None
MP1  A 800 (-3.6A)
MP1  A 800 (-4.8A)
MP1  A 800 (-4.6A)
None
 1.07A 2po7B-1c9eA:
34.6		 2po7B-1c9eA:
28.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO7_B_CHDB501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1c9e PROTOHEME FERROLYASE
(Bacillus
subtilis) 		5 / 12 SER A 121
HIS A 183
LEU A 185
PRO A 186
TRP A 230
 MP1  A 800 (-3.4A)
MP1  A 800 (-3.6A)
MP1  A 800 (-4.8A)
MP1  A 800 (-4.6A)
None
 1.06A 2po7B-1c9eA:
34.6		 2po7B-1c9eA:
28.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_A_CHDA801_0
(FERROCHELATASE)		 1c9e PROTOHEME FERROLYASE
(Bacillus
subtilis) 		5 / 12 SER A 121
HIS A 183
LEU A 185
PRO A 186
TRP A 230
 MP1  A 800 (-3.4A)
MP1  A 800 (-3.6A)
MP1  A 800 (-4.8A)
MP1  A 800 (-4.6A)
None
 1.01A 2qd4A-1c9eA:
35.0		 2qd4A-1c9eA:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RC0_A_SAMA484_0
(N-LYSINE
METHYLTRANSFERASE
SETD6)		 1c9e PROTOHEME FERROLYASE
(Bacillus
subtilis) 		5 / 11 VAL A  10
GLY A  85
ALA A  57
TYR A  17
LEU A  67
 None
 1.23A 3rc0A-1c9eA:
undetectable		 3rc0A-1c9eA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_C_ACTC502_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1c9e PROTOHEME FERROLYASE
(Bacillus
subtilis) 		3 / 3 PRO A  16
ASP A  21
GLU A  19
 None
 0.88A 3v4tC-1c9eA:
0.0		 3v4tC-1c9eA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 1c9e PROTOHEME FERROLYASE
(Bacillus
subtilis) 		4 / 6 ASP A 268
LEU A 263
TYR A 267
GLU A 272
 MG  A 900 ( 4.0A)
MP1  A 800 ( 4.5A)
None
MG  A 900 ( 4.2A)
 1.06A 3w9tB-1c9eA:
undetectable		 3w9tB-1c9eA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 1c9e PROTOHEME FERROLYASE
(Bacillus
subtilis) 		4 / 6 ASP A 268
LEU A 263
TYR A 267
GLU A 272
 MG  A 900 ( 4.0A)
MP1  A 800 ( 4.5A)
None
MG  A 900 ( 4.2A)
 1.05A 3w9tF-1c9eA:
undetectable		 3w9tF-1c9eA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 1c9e PROTOHEME FERROLYASE
(Bacillus
subtilis) 		4 / 8 SER A 121
HIS A 183
ILE A  29
GLU A 264
 MP1  A 800 (-3.4A)
MP1  A 800 (-3.6A)
MP1  A 800 (-4.5A)
MP1  A 800 (-4.3A)
 0.97A 4ms4A-1c9eA:
3.9		 4ms4A-1c9eA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_A_ADNA401_2
(ADENOSINE KINASE)		 1c9e PROTOHEME FERROLYASE
(Bacillus
subtilis) 		4 / 4 LEU A   8
SER A 110
LEU A 308
LEU A  67
 None
 0.95A 4n09A-1c9eA:
2.4		 4n09A-1c9eA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1c9e PROTOHEME FERROLYASE
(Bacillus
subtilis) 		4 / 6 ILE A  78
ALA A 301
VAL A 304
HIS A  70
 None
 0.73A 5eclD-1c9eA:
0.7		 5eclD-1c9eA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_D_LEUD602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 1c9e PROTOHEME FERROLYASE
(Bacillus
subtilis) 		4 / 8 ILE A  78
ALA A 301
VAL A 304
HIS A  70
 None
 0.87A 5ecnD-1c9eA:
undetectable		 5ecnD-1c9eA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESK_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1c9e PROTOHEME FERROLYASE
(Bacillus
subtilis) 		4 / 4 ALA A 292
PRO A  55
LEU A 263
HIS A 262
 None
None
MP1  A 800 ( 4.5A)
None
 1.44A 5eskA-1c9eA:
undetectable		 5eskA-1c9eA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VUO_B_MTLB805_0
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1c9e PROTOHEME FERROLYASE
(Bacillus
subtilis) 		4 / 8 SER A 181
ASN A 269
GLN A 236
ASP A 234
 None
 1.31A 5vuoB-1c9eA:
0.1		 5vuoB-1c9eA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YVN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE
OMEGA-1)		 1c9e PROTOHEME FERROLYASE
(Bacillus
subtilis) 		4 / 6 LEU A 113
GLN A  63
LEU A  67
LEU A 300
 None
 1.14A 5yvnA-1c9eA:
0.4		 5yvnA-1c9eA:
23.19