SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1c9l'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_F_ACTF3008_0
(BETA-CARBONIC
ANHYDRASE)		 1c9l CLATHRIN
(Rattus
norvegicus) 		4 / 8 GLN A 223
VAL A 220
GLY A 225
GLY A 226
 None
 0.84A 1ekjE-1c9lA:
undetectable
1ekjF-1c9lA:
0.0		 1ekjE-1c9lA:
21.19
1ekjF-1c9lA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 1c9l CLATHRIN
(Rattus
norvegicus) 		5 / 9 LEU A 325
LEU A  15
ILE A  38
VAL A 305
PHE A 304
 None
 1.31A 1gx8A-1c9lA:
0.5		 1gx8A-1c9lA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 1c9l CLATHRIN
(Rattus
norvegicus) 		5 / 12 THR A 302
GLY A 322
VAL A 262
VAL A 305
TYR A 279
 None
 1.26A 1n2xA-1c9lA:
undetectable		 1n2xA-1c9lA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 1c9l CLATHRIN
(Rattus
norvegicus) 		4 / 4 HIS A 197
VAL A 220
THR A 168
LEU A 183
 None
 1.28A 1oq5A-1c9lA:
undetectable		 1oq5A-1c9lA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1c9l CLATHRIN
(Rattus
norvegicus) 		4 / 8 SER A 200
ARG A 157
GLN A 203
PHE A 201
 None
 1.32A 1p6kA-1c9lA:
0.0		 1p6kA-1c9lA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1c9l CLATHRIN
(Rattus
norvegicus) 		4 / 8 SER A 200
ARG A 157
GLN A 203
PHE A 201
 None
 1.32A 1p6kB-1c9lA:
0.0		 1p6kB-1c9lA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1c9l CLATHRIN
(Rattus
norvegicus) 		4 / 8 SER A 200
ARG A 157
GLN A 203
PHE A 201
 None
 1.33A 1rs6A-1c9lA:
0.0		 1rs6A-1c9lA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS6_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1c9l CLATHRIN
(Rattus
norvegicus) 		4 / 8 SER A 200
ARG A 157
GLN A 203
PHE A 201
 None
 1.31A 1rs6B-1c9lA:
0.0		 1rs6B-1c9lA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RS7_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1c9l CLATHRIN
(Rattus
norvegicus) 		4 / 8 SER A 200
ARG A 157
GLN A 203
PHE A 201
 None
 1.29A 1rs7B-1c9lA:
0.0		 1rs7B-1c9lA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1c9l CLATHRIN
(Rattus
norvegicus) 		4 / 8 SER A 200
ARG A 157
GLN A 203
PHE A 201
 None
 1.34A 1zzqA-1c9lA:
0.0		 1zzqA-1c9lA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_B_MTLB871_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1c9l CLATHRIN
(Rattus
norvegicus) 		4 / 8 SER A 200
ARG A 157
GLN A 203
PHE A 201
 None
 1.31A 1zzuB-1c9lA:
0.0		 1zzuB-1c9lA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 1c9l CLATHRIN
(Rattus
norvegicus) 		5 / 12 MET A 181
ILE A 194
ALA A 199
VAL A 186
LEU A 183
 None
 1.21A 2rctA-1c9lA:
undetectable		 2rctA-1c9lA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VE3_A_REAA1445_1
(PUTATIVE CYTOCHROME
P450 120)		 1c9l CLATHRIN
(Rattus
norvegicus) 		5 / 12 LEU A 166
ALA A 199
VAL A 220
GLY A 222
GLN A 223
 None
 1.02A 2ve3A-1c9lA:
0.0		 2ve3A-1c9lA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 1c9l CLATHRIN
(Rattus
norvegicus) 		5 / 12 VAL A 273
TYR A 285
PRO A   6
ILE A 298
VAL A 327
 None
 1.28A 4eb6B-1c9lA:
undetectable
4eb6C-1c9lA:
undetectable		 4eb6B-1c9lA:
21.91
4eb6C-1c9lA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_C_ECNC403_1
(FLAVOHEMOGLOBIN)		 1c9l CLATHRIN
(Rattus
norvegicus) 		5 / 9 ILE A  53
GLN A  16
LEU A  15
VAL A 324
LEU A  30
 None
 1.26A 4g1bC-1c9lA:
undetectable		 4g1bC-1c9lA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 1c9l CLATHRIN
(Rattus
norvegicus) 		4 / 6 ARG A 297
ASP A 249
GLY A 222
THR A 277
 None
 1.01A 4l1aB-1c9lA:
undetectable		 4l1aB-1c9lA:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4S0V_A_SUVA2001_1
(HUMAN OREXIN
RECEPTOR TYPE 2
FUSION PROTEIN TO P.
ABYSII GLYCOGEN
SYNTHASE)		 1c9l CLATHRIN
(Rattus
norvegicus) 		5 / 12 THR A 214
VAL A 233
GLN A 203
GLU A 268
ILE A 230
 None
 1.32A 4s0vA-1c9lA:
undetectable		 4s0vA-1c9lA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5Q_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1c9l CLATHRIN
(Rattus
norvegicus) 		4 / 6 ARG A  64
ILE A  66
GLN A  49
ILE A  62
 None
 1.15A 4w5qA-1c9lA:
0.0		 4w5qA-1c9lA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1c9l CLATHRIN
(Rattus
norvegicus) 		4 / 6 ARG A  64
ILE A  66
GLN A  49
ILE A  62
 None
 1.09A 4w5tA-1c9lA:
0.0		 4w5tA-1c9lA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 1c9l CLATHRIN
(Rattus
norvegicus) 		3 / 3 LYS A  96
ILE A  93
ILE A  52
 None
 0.72A 4y0qA-1c9lA:
0.0		 4y0qA-1c9lA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1c9l CLATHRIN
(Rattus
norvegicus) 		4 / 8 LEU A 148
ILE A 170
GLY A 196
LEU A 166
 None
 0.78A 5eseA-1c9lA:
0.0		 5eseA-1c9lA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)		 1c9l CLATHRIN
(Rattus
norvegicus) 		5 / 12 THR A 312
ALA A 307
GLN A 265
ILE A 316
THR A 158
 None
 1.37A 5ewjC-1c9lA:
undetectable
5ewjD-1c9lA:
undetectable		 5ewjC-1c9lA:
23.04
5ewjD-1c9lA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGP_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1c9l CLATHRIN
(Rattus
norvegicus) 		5 / 12 ILE A  53
ALA A 307
VAL A 305
GLY A 314
THR A 312
 None
 1.45A 5igpA-1c9lA:
0.0		 5igpA-1c9lA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MLM_A_STRA401_1
(-)		 1c9l CLATHRIN
(Rattus
norvegicus) 		5 / 12 PHE A  37
ILE A  52
SER A  97
VAL A  79
ILE A  80
 None
 1.34A 5mlmA-1c9lA:
undetectable		 5mlmA-1c9lA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1c9l CLATHRIN
(Rattus
norvegicus) 		4 / 8 ILE A 335
LEU A 357
ILE A 334
ILE A 293
 None
 0.70A 5numA-1c9lA:
0.0		 5numA-1c9lA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA903_0
(PROTEIN ARGONAUTE-2)		 1c9l CLATHRIN
(Rattus
norvegicus) 		4 / 6 ARG A  64
ILE A  66
GLN A  49
ILE A  62
 None
 1.16A 6cbdA-1c9lA:
0.0		 6cbdA-1c9lA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GSD_A_STRA401_0
(PROGESTERONE
5-BETA-REDUCTASE)		 1c9l CLATHRIN
(Rattus
norvegicus) 		5 / 12 PHE A  37
ILE A  52
SER A  97
VAL A  79
ILE A  80
 None
 1.23A 6gsdA-1c9lA:
undetectable		 6gsdA-1c9lA:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1c9l CLATHRIN
(Rattus
norvegicus) 		4 / 6 GLN A 265
PHE A 274
LEU A 287
PHE A 204
 None
 1.21A 6nmpC-1c9lA:
undetectable
6nmpJ-1c9lA:
0.0		 6nmpC-1c9lA:
19.46
6nmpJ-1c9lA:
12.73